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References 1. Bønaa K, Mannsverk J, Wiseth R, et al. - Drug-eluting or bare-metal stents for coronary artery disease. N Engl J Med. 2016;375:1242-1252. 2. Kaneko H, Yajima J, Oikawa Y, et al. - Long-term incidence and prognostic factors of progression of new coronary lesions in Japanese coronary artery disease patients after percutaneous coronary intervention. Heart Vessels. 2014;29:437-442. 3. Park MW, Seung KB, Kim PJ, et al. - Long-term percutaneous coronary intervention rates and associated independent predictors for progression of nonintervened nonculprit

, Heald G, Lloyd A, Howland K, Davy M and James MF. Reliability and sensitivity of Joint Space Measurements in Hand Radiographs Using Computerized Image Analysis. J Rheumatol 2001; 28:1825-36. 5. Larsen A. How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long-term studies. J Rheumatol 1995; 22:1974-5. 6. Van Tuyl LHD, Voskuyl AE, Boers M, Geusens P, Landewé RMB, Dijkmans BAC et al. Baseline RANKL: OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis. Ann Rheum

. Detecting an overall survival benefit that is derived from progression-free survival. J Natl Cancer Inst 2009; 101: 1642-9. 10. Soria JC, Massard C, Le Chevalier T. Should progression-free survival be the primary measure of efficacy for advanced NSCLC therapy? Ann Oncol 2010; 21: 2324-32. 11. Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009; 27: 1227-34. 12. Hotta K

distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes. Immunity 2010; 33: 736-51. 59. Lim C, Savan R. The role of the IL-22/IL-22R1 axis in cancer. Cytokine Growth Factor Rev 2014; 25: 257-71. 60. Savan R, McFarland AP, Reynolds DA et al. A novel role for IL-22R1 as a driver of inflammation. Blood 2011; 117: 575-84. 61. Park O, Wang H, Weng H et al. In vivo consequences of liver-specific interleukin-22 expression in mice: implications for human liver disease progression. Hepatology 2011; 54: 252-61. 62. Riccardi C, Santoni A, Barlozzari

REFERENCES 1. Boyer B, Thiery J. Epithelium-mesenchyme interconversion as example of epithelial plasticity. Apmis 1993; 101: 257-68. 2. D’Souza-Schorey C. Disassembling adherens junctions: breaking up is hard to do. Trends Cell Biol 2005; 15: 19-26. 3. Hugo H, Ackland M, Blick T. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 2007; 213: 374-83. 4. Kang Y, Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004; 118: 277-9. 5. Thiery J. Epithelial-mesenchymal transitions

biochemistry of lipid peroxidation products . Free Radic Res. 2010; 44 :1098–1124. [9] ESTERBAUER H., SCHAUR RJ., ZOLLNER H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991; 11 :81–128. [10] FARMER EE., DAVOINE C. Reactive electrophile species . Curr Opin Plant Biol. 200; 10 (4): 380–6. [11] BARRERA G. Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncol. 2012; 2012 :137289. [12] HONGLERTSAKUL C., OPANURAKS J., KITTIKOWIT W., BOONLA C., WUNSUWAN R., TOSUKHOWONG P

Abstract

The use of cartographic sources and methods are the basic tools of historical geography. One of the main research trends in this field is the analysis of the spatial layout and number of old settlement units. The confrontation of maps with historical data allows the drawing of a town’s area at a certain time to be studied. The retrogression (R) and progression (P) methods that are currently used are imperfect and the model created (map) is usually incomplete and its reliability is limited. In the author’s opinion, the joining of retrogression and progression (a new method; combined – K)1 increases the quality of cartographic reconstruction of natural and cultural landscapes. The use of basic mathematical methods from the scope of set operations means the component reliability of the researched cartographic model can be varied because the common part of the retrogression and progression cartographic model represents mutual verification of source data. Quantitative effectiveness assessments of retrogression (R), progression (P) and the combined method (K) can be made for countable elements (e.g. buildings). As part of the conducted study, the effectiveness of separate methods was calculated: R = 76% for retrogression, P = 59% for progression and K = R ∪ P = 85% for the combined method. The mutual verification of the methods (R ∩ P) included 45% of residential buildings. The author describes the proposition of a new method and the course of verification research.

, Ikeda H. Expression of ICAM-1 on glomeruli is associated with progression of diabetic nephropathy in a genetically obese diabetic rat, Wistar fatty. Diabetes Res Clin Pract 1996; 32(1-2):1-9 13. Watanabe N, Shikata K, Shikata Y, Sarai K, Omori K, Kodera R, et al. Involvement of MAPKs in ICAM-1 expression in glomerular endothelial cells in diabetic nephropathy. Acta Med Okayama. 2011 Aug;65(4):247-57 14. Okada S, Shikata K, Matsuda M, Ogawa D, Usui H, Kido Y, et al. Intercellular adhesion molecule-1 deficient mice are resistant against renal injury after induction of

Abstract

This study assessed the progression of Pb, Cd and Cr concentrations in plastic components (PCs) and printed wiring boards (PWBs) of 59 end-of-life (EoL) mobile phones (MPs) produced between 2000 and 2015 by two leading original equipment manufacturers (OEMs) patronized by Nigerians. This was done to study the behavior of OEMs in complying with some widely acceptable regulations. Metals in PCs and PWBs of MPs were extracted following EPA 3050B method and extracts were analyzed using atomic absorption spectrophotometry technique. Furthermore, Toxicity Characteristic Leaching Procedure (TCLP) test was conducted on selected samples to assess metal leachability in landfill conditions. Summary of results (mg/kg) for PCs and PWBs for MPs produced by OEM 1 and OEM 2 in brackets ranged thus: PCs, Pb: 5.00 –195 (LOD-1750), Cr: LOD-6050 (LOD-2170) and Cd: LOD-1.00 (LOD-5.75) while PWBs, Pb:129-9750 (5.00-12125), Cr: LOD-5488 (LOD-4000) and Cd: LOD-1.00 (0.25-1.00). There were no regular trends for all metals for both OEMs. Results suggest that a greater percentage of MPs produced till 2015 contained Pb and Cr higher than RoHS and TTLC limits. Furthermore, 50% of TCLP extracts contain Pb higher than EPA limit of 5 mg/L. Therefore, EoL MPs arising in Nigeria should be handled as hazardous materials.

-Time quantitative PCR and the 2-DDCT method. Methods 2001; 25: 402-8. 18. Amati B, Alevizopoulos K and Vlach J. Myc and the cell cycle. Frontiers Biosci 1998; 3: D250-68. 19. Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis 2000; 21: 485-95. 20. Todd R, Donoff RB,Wong DTW. The molecular biology of oral cancer: toward a tumour progression model. J Oral Maxillofac Surg 1997; 55: 613-23. 21. Bettendorf O, Piffko’ J, Bankfalvi A. Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy? Oral Oncol 2004; 40: 110-9. 22. Wang C