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Genes regulating programmed cell death are significantly upregulated in porcine immature oocytes

.1016/J.THERIOGENOLOGY.2012.03.012. 17. Walter W, Sánchez-Cabo F, Ricote M. GOplot: An R package for visually combining expression data with functional analysis. Bioinformatics. 2015;31:2912–4; DOI:10.1093/bioinformatics/btv300. 18. Tiwari M, Prasad S, Tripathi A, Pandey AN, Ali I, Singh AK, Shrivastav TG, Chaube SK. Apoptosis in mammalian oocytes: a review. Apoptosis. 2015;20:1019–25; DOI:10.1007/s10495-015-1136-y. 19. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495–516; DOI:10.1080/01926230701320337. 20

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Apoptosis Regulation by Inhibitors of Programmed Cell Death

References 1. Elmore S. Apoptosis: A review of programmed cell death. Toxicol Pathol 2007; 2(7): 545-50. 2. Bhola PD, Simon SM. Determinism and divergence of apoptosis susceptibility in mammalian cells. J Cell Sci 2009; 122(23): 4296-302. 3. Fulda S, Debatin KM. Targeting Inhibitor of Apoptosis Proteins (IAPs) for Diagnosis and Treatment of Human Diseases. Recent Pat Anticancer Drug Discov 2006; 1: 81-9. 4. Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS. Caspase 3 attenuates XIAP (X

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Recent Findings of the Types of Programmed Cell Death


Cell death plays an important role in maintaining the homeostasis of multicellular organisms. It can occur in a controlled manner by apoptosis or autophagy. Cell death which occurs regardless of regulatory factors include necrosis, mitotic catastrophe or oncosis.

Apoptosis and necrosis are cellular process that leads to cell death. However their mechanisms are different, although factors triggering them can be similar. Necrosis and apoptosis have many different characteristics in terms of biochemistry and morphology.

There are two main pathways of apoptosis induction signal: receptor - dependent and mitochondrial. The outsider apoptotic pathway is induced by external factors stimulating membrane receptors having an intracellular domain called death domain.

Mitochondrial apoptotic pathway is activated by increased concentration of reactive oxygen species (ROS), DNA damage, disorders electrolyte transport and an increase in the concentration of the calcium ions in the cytoplasm. In response to stress-factors, mitochondrial channels are opened, so that is released into the cytoplasm cytochrome C. This work is aimed at an overall description of exchanged processes.

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Apoptotic factors in physiological and pathological processes of teeth and periodontal tissues – literature review

References 1. Bielak- Żmijewska A.: Resistance to apoptosis mechanisms of neoplastic cells., Kosmos problemy nauk biologicznych., 52,2-3,2003 2. Edamatsu M., et all.: Apoptosis - related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible., Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 99,17,2005 3. Filip A.: Apoptosis - programmed cell death., Cz I Almamater., 1,46,2003 4. Filip A.: Apoptosis - programmed cell

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Proteases with caspase 3-like activity participate in cell death during stress-induced microspore embryogenesis of Brassica napus

; 69(6): 1387-402. 11. Pérez-Pérez Y, Carneros E, Berenguer E, Solís MT, Bárány I, Pintos B, Gómez-Garay A, Risueño MC, Testillano PS. Pectin de-methylesterification and AGP increase promote cell wall remodeling and are required during somatic embryogenesis of Quercus suber . Frontiers in Plant Science. 2019; 9: 1915. 12. Daneva A, Gao Z, Van Durme M, Nowack MK. Functions and regulation of programmed cell death in plant development. Annual Review of Cell and Developmental Biology. 2016; 32: 441-68. 13. Huysmans M, Lema S, Coll NS, Nowack MK. Dying

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Management of immune-related adverse events in patients treated with immune checkpoint inhibitors– Rheumatology point of view

1 Introduction The immune checkpoints, such as cytotoxic T-lymphocyte-associated antigen 4, programmed cell death protein and programmed cell death protein ligand 1, were the normal self-regulatory pathways to control T-cell activities in human body. In tumor microenvironment, these molecules were overexpressed to inhibit the normal T-cell function and survival, leading to an escape from the destruction from immune system. The immune checkpoint inhibitors (ICPis) block this mechanism and restore the T-cell immunity to achieve tumor destructions. However, the

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Soluble sPD-L1 and serum amyloid A1 as potential biomarkers for lung cancer

97671 82 5 Okuma Y, Hosomi Y, Nakahara Y, et al. High plasma levels of soluble programmed cell death ligand 1 are prognostic for reduced survival in advanced lung cancer. Lung Cancer 2017;104:1–6. 10.1016/j.lungcan.2016.11.023 Okuma Y Hosomi Y Nakahara Y High plasma levels of soluble programmed cell death ligand 1 are prognostic for reduced survival in advanced lung cancer Lung Cancer 2017 104 1 6 6 Park HJ, Park JS, Jeong YH, et al. Correction: PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8

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Targeting the PD-1/PD-L1 axis in the treatment of lung cancer

September 6-9 2015, ORAL02.07 [36] Rizvi N, Brahmer J, Ou SH, Segal NH, Khleif S, Hwu WJ et al. Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33:abstr 8032. Rizvi N Brahmer J Ou SH Segal NH Khleif S Hwu WJ et al Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC) J Clin Oncol 2015 33 abstr 8032 [37] Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ

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Overview and management of toxicities of immune checkpoint-blocking drugs

-stimulatory and co-inhibitory signals, which normally regulates immune response and prevents autoimmunity, is deranged by the cancer cell to escape immune surveillance ( 1 - 2 ). Among co-inhibitory signals, immune checkpoints represent immunological breaks that repress activating effects in order to avoid unchecked self-destruction of normal tissues ( 3 ). Cytotoxic T lymphocyte Antigen 4 (CTLA-4) and Programmed Cell Death protein 1 (PD-1) are the two main inhibitory checkpoint pathways involved. CTLA-4 exerts its effects when it is expressed on the surface of CD4+ and CD8

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Identifying Biomarkers of Autophagy and Apoptosis in Transfected Nuclear Donor Cells and Transgenic Cloned Pig Embryos

., 2015: 814686. Sandrin V., Boson B., Salmon P., Gay W., Nègre D., Le Grand R., Trono D., Cos-set F.L. (2002). Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates. Blood, 100: 823–832. Schwartz L.M., Smith S.W., Jones M.E., Osborne B.A. (1993). Do all programmed cell deaths occur via apoptosis? Proc. Natl. Acad Sci. USA, 90: 980–984. Shen X., Zhang N., Wang Z., Bai G., Zheng Z., Gu Y., Wu Y

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