Zhen Jiao, Ziyi Wang, Xiudong Wang and Wenjing Fan
The operation parameters for the supercritical carbon dioxide (ScCO2) evaporation method greatly affect the properties of the prepared drug-loaded micelles. In this study, the effects of those key parameters on the drug-loading content (LC) and drug entrapment efficiency (EE) are discussed. It is observed that EE and LC of the micelles are slightly increased with the enhancing temperature and the copolymer molecular ratio of hydrophilic/hydrophobic segment, while decreased with the enhancing ScCO2 evaporation rate. The pressure and volume ratio of ScCO2 to H2O are observed the optimum condition. In addition, the verification experiment is carried out under the obtained optimizing parameters. The prepared micelles exhibit relatively regular spherical shape and narrow size distribution with the EE and LC value of 70.7% and 14.1%, respectively.
In order to obtain the optimal technological parameters of lettuce vacuum osmotic dehydration, the effects of osmotic temperature, slice thickness, sucrose concentration, and vacuum degree on the vacuum osmotic dehydration were explored. The lettuce water loss rate and solid gain rate decreased with the increase of slice thickness and vacuum degree, and increased with the increase of sucrose concentration and osmotic temperature. Response surface methodology was applied to analyze the influence of the four influential factors on the evaluated parameters and the optimization of lettuce vacuum osmotic dehydration was studied. The results indicated that, within the experimental scope, the optimized technological parameters of lettuce vacuum osmotic dehydration are the temperature of 28°C, the slice thickness of 2 mm, sucrose concentration of 47%, the vacuum degree of 22 kPa, and the water loss rate and solid gain rate are 72.16% and 11.82%, respectively.
Friction stir processing (FSP) is solid state novel technique developed to refine microstructure and to improve the mechanical properties and be used to fabricate the aluminium alloy matrix composites. An attempt is made to fabricate AA6061/TiB2 aluminium alloy composite (AMCs) and the influence of process parameters like rotational speed, transverse feed, axial load and percentage reinforcement on microstructure and mechanical properties were studied. The microstructural observations are carried out and revealed that the reinforcement particles (TiB2) were uniformly dispersed in the nugget zone. The Tensile strength and Hardness of composites were evaluated. It was observed that tensile strength, and hardness were increased with increased the rotational speed and percentage reinforcement of particles. The process parameters were optimized using Taguchi analysis (Single Variable) and Grey analysis (Multi Variable). The most influential parameter was rotational speed in single variable method and multi variable optimization method. The ANOVA also done to know the percentage contribution of each parameter.
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