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Gholamreza Jandaghi, Zohreh Khalajinia and Parvaneh Moghadam
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Gunningham FG, Gant NF, Leveno KJ, Gilstrap LC, Tauth JC, Wenstrom KD. Williams
Blanka Borowiec, Tomasz Hadada and Magdalena Kosińska
This study focused on the role of polymorphisms in prostaglandin expression regulating genes in the occurrence of early uterine contractions during pregnancy. The analyzed genes were: PLA2G4C, encoding calcium independent phospholipase A2, and PLA2G4C, encoding IVD phospholipase A2. It was examined if known reference polymorphisms in these genes (rs1366442, [A/C/T] for PLA2G4C; and rs4924618, [A/T] for PLA2G4D), have any influence on preterm birth. Additionally, other biological, genetic and socio-economic factors were taken into account and analyzed, based on their role in induction of early resolve of pregnancy in the study group. Blood samples were taken from 20 patients. 15 of them gave birth preterm, 5 gave birth at the predicted date of pregnancy resolve. DNA was isolated from the samples, and subjected to PCR, with obtained amplified samples separated using electrophoresis on 1,5% agarose gel. Resulting material was subjected to high-throughput sequencing. Statistical analysis was performed using Statistica 13 software. Analyses have shown that the discussed biological, genetic and societal-economic factors have statistically significant influence on preterm birth. Sequencing results presented the suspected presence of the analyzed SNPs in most women from the studied groups, while not showing their presence in any of the controls. The biological, genetic, and socio-economic factors analyzed have a significant influence on pre-term birth. Presence of SNPs in PLA2G4C and PLA2G4D genes may increase the risk of early resolve of pregnancy. However, as the control and study groups were relatively small, it is suggested to repeat the studies on bigger samples to validate the results.
Ivan D. Ivanov, Stefan A. Buzalov and Nadezhda H. Hinkova
, S, Paavonen J, Tapper AM. Pretermdelivery after surgical treatment for cervical intraepithelial neoplasia. Obstet Gynecol. 2007;109(2 Pt1):309-13.
14. Goldenberg RL, Davis RO, Cutter GR, Hoffman HJ, Brumfield CG, Foster JM. Prematurity, postdates, and growth retardation: the influence of use of ultrasonography on reported gestational age. Am J ObstetGynecol. 1989;160(2):462-70.
15. Ambrose CS, Caspard H, Rizzo C, Stepka EC, Keenan G. Standard methods based on last menstrual period dates misclassify and overestimate US preterm births. J Perinatol. 2015
Vislava Globevnik Velikonja, Tina Lozej, Gaja Leban, Ivan Verdenik and Eda Vrtačnik Bokal
proven higher multiple pregnancy rate registered in IVF pregnancies ( 7 ), which is a known risk factor for pretermdelivery and consequently for increased neonatal morbidity and mortality ( 8 ), there are other unfavourable effects of IVF conception on pregnancy, as well as the effect of infertility on psychological well-being and quality of life of women who conceive after infertility treatment. The high frequency of multiple births and the high maternal age are interpreted as contributing factors, not the IVF technique itself. Some authors ( 9 , 10 ) did not find
Marta Borowska, Ewelina Brzozowska and Edward Oczeretko
Prevention and early diagnosis of forthcoming preterm labor is of vital importance in preventing child mortality. To date, our understanding of the coordination of uterine contractions is incomplete. Among the many methods of recording uterine contractility, electrohysterography (EHG) – the recording of changes in electrical potential associated with contraction of the uterine muscle, seems to be the most important from a diagnostic point of view. There is some controversy regarding whether EHG may identify patients with a high risk of preterm delivery. There is a need to check various digital signal processing techniques to describe the recorded signals. The study of synchronization of multivariate signals is important from both a theoretical and a practical point of view. Application of the Hilbert transformation seems very promising.