Eduard Adamescu, Cătălina Niculescu and Carmen Dobjanschi
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7. Ryden L, Standl E, Bartnik M et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 28: 88-136, 2007.
8. World Health Organisation “Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a
Tetiana Ashcheulova, Oksana Kochubiei, Ganna Demydenko, Nina Gerasimchuk and Alla Maliy
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6. Miyaoka Y. Tanaka M, Naiki T, Miyajima A. Oncostatin M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways. J Biol Chem 281: 37913–37920, 2006.
7. Al-Khalili L, Bouzakri K, Glund S, Lönnqvist F
Vera Zdravković, Silvija Sajić, Jadranka Mitrović, Igor Stefanović, Polina Pavićević, Dimitrije Nikolić, Jovana Dimić and Nebojša M. Lalić
1. Bacha F, Gungor N, Lee S, Arslanian SA. In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes? Diabetes Care 2009; 32(1): 100-5.
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Maria-Magdalena Sandu, Diana Cristina Protasiewicz, Adela Gabriela Firănescu, Elena Cristina Lăcătuşu, Mihaela Larisa Bîcu and Maria Moţa
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We looked for easy-to-use and predictable tools for identifying early risk ofprediabetes (PD) and preventing the natural course to diabetes in overweight andobese pre-teens and adolescents. In 89 children (9-18 years) family history, bodymass index (BMI), waist circumference (WC), acanthosis nigricans, blood pressure(BP), lipids, HbA1c, fasting glucose and oral glucose tolerance test were determined.We found 69 (77.5%) obese (BMI≥95th percentile) and 20 (22.5%) overweightchildren (BMI 85th-95th percentiles); thirty-six (41.4%) had PD; two had type 2diabetes mellitus; two had metabolic syndrome. PD was associated with obesity (RR5.1), HbA1c>5.5% (RR 2.5), acanthosis nigricans (RR=1.9), malegender (RR = 1.9), total cholesterol ≥170 mg/dL (RR=1.8), high BP (RR=1.7), urbanarea (RR = 1.6). BMI, WC, HbA1c and acanthosis nigricans are the majorpredictors for PD in this population. All blood values are both easy to measure andto accept by children, using finger prick method.
Andrijana Milošević Georgiev, Dušanka Krajnović, Jelena Kotur-Stevuljević, Svetlana Ignjatović and Valentina Marinković
for the prevention or delay of type 2 diabetes mellitus in prediabetes: a systematic review of randomised controlled trials. Australian and New Zealand Journal of Public Health 2010; 34(2): 172-8.
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9. Ministarstvo zdravlja Republike
Objectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in inflammation, insulin resistance, and vascular damage. This study aimed to analyze the relationship between the polymorphisms in TLR4 gene and different stages in the glucose continuum from prediabetes to the type 2 diabetes and chronic microvascular complications.
Materials and Methods. The study included 113 patients with the type 2 diabetes, 29 participants with prediabetes, and 28 controls. Polymerase chain reaction (PCR) was used for genotyping Asp299Gly and Thr399Ile polymorphism, followed by restriction analysis.
Results. The difference in the genotype frequency for both polymorphisms in patients with the type 2 diabetes or prediabetes compared to that in controls was not significant. Patients with heterozygous genotype of Asp299Gly polymorphism had a higher prevalence of diabetic retinopathy (42.9%) than participants with homozygous genotype (9.0%) (OR [95%CI]=7.61 [1.41–41.08]; p=0.018). No association was established for diabetic polyneuropathy and nephropathy. Prevalence of chronic diabetes complications was not related to Thr399Ile polymorphism.
Conclusion. Our study demonstrates that Asp299Gly and Thr399Ile polymorphisms seem not to be associated with the type 2 diabetes and prediabetes but Asp299Gly may contribute to diabetic retinopathy predisposition.
in Diabetes Mellitus: a Meta-Analysis and Systematic Review of Plasma and Serum Studies. Biol Trace Elem Res 2017; 177: 53-63.
20. Skalnaya MG, Skalny AV, Tinkov AA. Serum copper, zinc, and iron levels, and markers of carbohydrate metabolism in postmenopausal women with prediabetes and type 2 diabetes mellitus. J Tra ce Elem Med Biol 2017; 43: 46-51.
21. Jamilian M, Samimi M, Ebrahimi FA, Aghadavod E, Mohammadbeigi R, Rahimi M, Asemi Z. Effects of Selenium Supplementation on Gene Expression Levels of Inflammatory Cytokines and Vascular Endothelial
Marieni Bello, Maria Cirilo Sousa, Gabriel Neto, Leonardo Oliveira, Ialuska Guerras, Romeu Mendes and Nelson Sousa
The aim of this study was to evaluate the impact of a community-based exercise program on bone mineral density and body composition in postmenopausal women with pre-diabetes and type 2 diabetes. Twenty postmenopausal women (aged 61.3 ± 6.0 years) with pre-diabetes and type 2 diabetes were randomly assigned to a community-based exercise program group (n=10) or a control group (n=10). The community-based exercise program was multicomponent, three days per week for 32 weeks, and included walking, resistance and aquatic exercises. Body composition and bone mineral density were measured pre and post-training by dual X-ray absorptiometry. In the exercise group significant increases were found in the ward’s triangle bone mineral density (+7.8%, p=0.043), and in fat-free mass (+2.4%, p=0.018). The findings suggest that regular multicomponent training is effective in preventing osteoporosis and sarcopenia among postmenopausal women with pre-diabetes and type 2 diabetes.
Bogdan Mircea Mihai, Didona Anca Ungureanu, Antoniu Octavian Petriş and Cristina Mihaela Lăcătuşu
) subclasses are increased with decreased activity of HDL-associated phospholipase A2 in subjects with prediabetes. Lipids 48: 547-555, 2013.
13. Lin KC, Tsai ST, Lin HY, Chou P. Different progressions of hyperglycemia and diabetes among hyperuricemic men and women in the kinmen study. J Rheumatol 31: 1159-1165, 2004.
14. Ishizaka N, Ishizaka Y, Toda E, Nagai R, Yamakado M. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol 25: 1038-1044, 2005