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Simona Bucerzan, Radu Anghel Popp, Raluca Maria Vlad, Cecilia Lazea, Radu Nicolaescu and Paula Grigorescu-Sido
MTR =Methionine synthase
MTRR =Methionine synthase reductase
MTHFD =Methylenetetrahydrofolate dehydrogenase
MTHFR =Methylenetetrahydrofolate reductase
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Anca Meda Georgescu, Claudia Bănescu, Iudita Badea, Valeriu Moldovan, Adina Huțanu, Septimiu Voidăzan, Minodora Dobreanu and Leonard Azamfirei
RFLP =Restriction fragment length polymorphism
SAPS II =Simplified Acute Physiology Score – II
SD =Standard deviation
SNP =Single nucleotide polymorphism
SOFA =Sequential Organ Failure Assessment
SPSS =Statistical Package for Social Sciences
VLBW =Very low birth weight
1. Mariansdatter SE, Eiset AH, Søgaard KK, Christiansen CF. Differences in reported sepsis incidence according to study design: a literature review. BMC Med Res Methodol. 2016 Oct;16(1)137. DOI 10.1186/s12874-016-0237-9. DOI: 10.1186/s12874-016-0237-9
Paweł Cięszczyk, Aleksandra Zarębska, Zbigniew Jastrzębski, Michał Sawczyn, Izabela Kozakiewicz-Drobnik, Agata Leońska-Duniec, Mariusz Kaczmarczyk, Agnieszka Maciejewska-Skrendo, Piotr Żmijewski, Grzegorz Trybek, Wojciech Smółka, Jan Pilch, Katarzyna Leźnicka, Ewelina Lulińska-Kuklik, Marek Sawczuk and Myosotis Massidda
, involved in DNA methylation, the process of covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide ( Terruzzi et al., 2011 ). A large body of evidence has demonstrated that the methylation of the DNA is associated with the regulation of gene expression and it has been found to be involved in inhibition of gene expression ( Klose and Bird, 2006 ). Several polymorphic sites have been described within MTHFR, however, two of them i.e., C677T and A1298C, commonly occur and are most thoroughly explored. The C677T polymorphism has been