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. (2008). Electrospun water-soluble carboxyethyl chitosan/poly (vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Biomacromolecules, 9(1), 349-354 [25] Huang, X., Sun, Y., Nie, J., Lu, W., Yang, L., et al. (2015). Using absorbable chitosan hemostatic sponges as a promising surgical dressing. International Journal of Biological Macromolecules, 75, 322-329 [26] Barzegari, A., Shariatinia, Z. (2018). Fabrication of Chitosan-polyethylene oxide electrospun nanofibrous mats containing green tea extract. Iranian Journal of Chemical

REFERENCES 1. C. J. Kim, Drug release from compressed hydrophilic POLYOX-WSR tablets, J. Pharm. Sci. 84 (1995) 303–306; 2. L. Maggi, R. Bruni and U. Conte, High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms, Int. J. Pharm. 195 (2000) 229–238; 3. A. Apicella, B. Cappello, M. A. Del Nobile, M. I. La Rotonda, G. Mensitieri and L. Nicolais, Poly (ethylene oxide) (PEO) and different molecular weight PEO blends monolithic


Chitosan has been successfully incorporated as a filler in a polyethylene oxide (PEO) and lithium trifluoromethanesulfonate (LiCF3SO3) matrix with a combination of plasticizers, namely 1,3-dioxolane (DIOX) and tetraethylene glycol dimethylether (TEGDME). The composite gel-polymer electrolyte (CGPE) membranes were prepared by solution casting technique in an argon atmosphere. The prepared membranes were subjected to SEM, TG/DTA and FT-IR analyses. A Li/CGPE/Li symmetric cell was assembled and the variation of interfacial resistance was measured as a function of time. The lithium transference number (Li+ t) was measured and the value was calculated as 0.6 which is sufficient for battery applications. The electrochemical stability window of the sample was studied by linear sweep voltammetry and the polymer electrolyte was found to be stable up to 5.2 V.


The objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance solubility. Non-effervescent floating tablets were prepared with a combination of optimized solid dispersions and release retarding polymers/swellable polymers such as xanthan gum and polyethylene oxide. Tablets were evaluated for physicochemical properties such as hardness, thickness and buoyancy. SD prepared with the drug to poloxamer ratio of 1:4 by melt granulation showed a higher dissolution rate than all other dispersions. Formulations containing 40 mg of polyethylene oxide (C-P40) and 50 mg xanthan gum (C-X50) were found to be best, with the drug retardation up to 12 hours. Optimized formulations were characterized using FTIR and DSC and no drug and excipient interactions were detected.


The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compression was used to formulate floating tablets and the tablets were evaluated for their physicochemical and dissolution characteristics. PEO based formulations produced better drug release properties than other formulations. Hence, it was further optimized by central composite design. Further subjects of research were the effect of formulation variables on floating lag time and the percentage of drug released at the seventh hour (D 7h). The optimum quantities of PEO and sodium bicarbonate, which had the highest desirability close to 1.0, were chosen as the statistically optimized formulation. No interaction was found between theophylline and PEO by Fourier Transformation Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies.

References Gun'ko V. M., Mironyuk I. F., Zarko V. I., Turov V. V., Voronin E. F., Pakhlov E. M., Goncharuk E. V., Leboda R., Skubiszewska-Zięba J., Janusz W., Chibowski S., Levchuk Yu. N., Kluyeva A. V. Fumed silicas prossessing different morphology and hydrophilicity, J. Colloid Interface Sci. , 2001, 242, 90. Sierra L., Guth J-L. Synthesis of mesoporous silica with tunable pore size from sodium silicate solutions and a polyethylene oxide surfactants, Microporous Mesoporous Mater. , 1999, 27, 243. Schlomach J, Kind M. Investigation on the semibatch

) 620-624. K. Edsman, J. Carlfors and R. Petersson, Rheological evaluation of poloxamer as an in situ gel for ophthalmic use, Eur. J. Pharm. Sci.   6 (1998) 105-112; DOI: 10.1016/S0928-0987(97)00075-4. H. Qi, L. Li, C. Huang, W. Li and C. Wu, Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use, Chem. Pharm. Bull.   54 (2006) 1500-1507; DOI 10.1248/cpb.54.1500. A. Cabana, A. Ait-Kadi and J. Juhasz, Study of the gelation process of polyethylene oxide-poly-propylene oxide-polyethylene oxide

.2016.42008. 8. Nie ZQ, Wang M, Zheng Y (2012) Application of Three Molecular Biotechnologies in Microbial Diversity of Microorganisms from Traditional Fermented Foods. Food Science, 33(23): 346-350. 9. Shestakov SV (2012) Impact of metagenomics on biotechnological development. Applied Biochemistry and Microbiology, 48(9): 705-715. DOI: 10.1134/S0003683812090050 10. Sluis C, Stoffelen C J P, Castelein S J, Engbers GHM, Schure EGT (2001) Immobilized salt-tolerant yeasts: application of a new polyethylene-oxide support in a

, N. (2001). Studies on high-speed melt spinning of noncircular cross-section fibers II. On-line measurement of the spin line, including change in cross-sectional shape. Journal of Applied Polymer Science, 80, 1582-1588. [22] Yao, D. (2006). Fundamental study of the driving mechanisms for cross-section shape change in highly noncircular fiber spinning. The Fiber Society, Fall Annual Meeting and Technical Conference, 55-56. [23] Thuc, C.N.H., Grillet, A.C., Reinert, L. & Ohashi, F. (2010). Separation and purification of montmorillonite and polyethylene oxide modified

, Optimization and characterization of a pH-independent extended-release hydrophilic matrix tablet, Pharm. Dev. Technol. 2 (1997) 25-31. R. J. MacRae and J. S. Smith, Controlled-release Pharmaceutical Formulations Containing Low Molecular Weight Polyethylene Oxide and Hydroxypropylmethyl Cellulose , WO Pat. 97/18814, 29 May 1997; ref. Chem. Abstr. 127 (1997) 55911u; DOI: 10.1016/0032-3861(94)90913-X. K. Nam, J. Watanabe and K. Ishihara, pH-modulated release of insulin entrapped in a spontaneously formed hydrogel system composed of two water-soluble phospholipid polymers