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References 1. Kostova I. Platinum complexes as anticancer agents. Recent Pat Anticancer Drug Discov. 2006; 1(1):1-22. 2. Alderden RA, Hall MD, Hambley TW. The Discovery and Development of Cisplatin. J Chem Educ. 2006; 83(5): 728-33. 3. Florea АМ, Busselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers. 2011; 3(1): 1351-71. 4. Mishra AK, Mishra SB, Manav N, Saluja D, Chandra R, Kaushik NK. Synthesis, characterization, antibacterial and cytotoxic study of platinum(IV) complexes. Bioorg Med

). What do we know about the reduction of Pt(IV) pro-drugs? J Inorg Biochem. 117, 220-229. 41. Horváth, V., Blanárová, O., Svihálková-Sindlerová, L., Soucek, K. Hofmanová, J., Sova, P., Kroutil, A., Fedorocko, P., & Kozubík, A. (2006). Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells. Gynecol Oncol. 102(1), 32-40. 42. Svihálková-Sindlerová, L., Foltinová, V., Vaculová, A., Horváth, V., Soucek, K., Sova, P., Hofmanová, J., & Kozubík, A. (2010). LA-12 overcomes confluence-dependent resistance of HT-29 colon

, N. & Öğütçü, H. (2012). Polystyrene containing carbinolamine/azomethine potentially useful as antimicrobial agent synthesis and biological evaluation. J. Inorg. Organomet. Polym. Mater. 22, 1146-1155. DOI: 10.1007/ s10904-012-9697-5. 21. Swihart, D.L. & Mason, W.R. (1970). Electronic spectra of octahedral platinum (IV) complexes. Inorg. Chem. 9, 1749-1757. DOI: 10.1021/ic50089a029. 22. Keland, L.R., Mistry, P., Abel, G., Loh, S.Y., O’Neil, C.F., Murer, B.A. & Harrap, K.R. (1992). Mechanism-related circumvention of acquired cis- diamminedichloroplatinum (II

apoptosis. Cancer Res. 2000; 60(7): 1789-92. 20. Icli F, Karaouguz H, Dincol D et al. Sever vascular toxicity associated with cisplatin-based chemotherapy. Cancer. 1993; 72(2): 587-93. 21. Dieckmann KP, Struss WJ, Budde U. Evidence for acute vascular toxicity of cisplatin-based chemotherapy in patients with germ cell tumour. Anticancer res. 2011; 31(12): 4501-6. 22. Galanski M, Keppler BK. Synthesis and characterization of new ethylendiamine platinum(IV) complexes containg lipophilic carboxylate ligands. Metal Based Drugs. 1995; 2: 57-63. 23. Pai VB, Nahata MC

, characterization and in vitro antitumoral activity of platinum (IV) complexes with O,O′-dialkyl-(S,S)-ethylenediamine-N,N′-di-2-(4-methyl) pentanoate ligands. Inorganica Chimica Acta. 390, 123-128. 15. Habashi F. (2013) Platinum, Physical and Chemical Properties In: Kretsinger RH, Uversky VN & Permiyakov EA. Encyclopedia of Metalloproteins (pp.1741-1742). New York, Heidelberg, Dordrecht, London:Springer. 16. Palm-Espling ME & Wittung-Stafshede P. (2013) Platinum Interaction with Copper Proteins. In: Kretsinger RH, Uversky VN & Permiyakov EA. Encyclopedia of Metalloproteins (pp

in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95(2): 351–8. 23. Galanski M, Keppler BK. Synthesis and characterization of new ethylendiamine platinum (IV) complexes containing lipophilic carboxylate ligands. Metal Based Drugs 1995; 2: 57-63. 24. Ma H, Jones KR, Guo R, Xu P, Shen Y, Ren J. Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: role of endoplasmic reticulum stress. Clin Exp Pharmacol Physiol 2010; 37: 460-5. 25. Ferroni P, Della-Morte D, Palmirotta R, McClendon M, Testa G, Abete P et al

pharmacological properties of a novel platinum (IV) complex: trans -[PtCl 2 (OH) 2 (dimethylamine) (isopropylamine)]. Mol Pharmacol 2003; 63 : 933-44. 10.1124/mol.63.4.933 Perez JM Kelland LR Montero EI Boxall FE Fuertes MA Alonso C Antitumor and cellular pharmacological properties of a novel platinum (IV) complex: trans -[PtCl 2 (OH) 2 (dimethylamine) (isopropylamine)] Mol Pharmacol 2003 63 933 44 42 Cemazar M, Miklavcic D, Vodovnik L, Jarm T, Rudolf Z, Stabuc B, et al. Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration

and genetic basis of interindividual variability of response to cisplatin and other metal based compounds summarized in this review may therefore help the oncologist to better understand the mechanism of their cytostatic action. References 1 Rosenberg B, Van Camp L, Grimley EB, Thomson AJ. The inhibition of growth or cell division in Escherichia coli by different ionic species of platinum(IV) complexes. J Biol Chem 1967; 242: 1347-52. PMID: 5337590 5337590 Rosenberg B Van Camp L Grimley EB Thomson AJ The inhibition of growth or cell division in Escherichia coli by