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Lattanzio V., Lattanzio V.M.T., Cardinali A., 2006, Role of phenolics in the resistance mechanisms of plants against fungal pathogens and insects, [In:] Imperato F. (ed.), Phytochemistry: Advances in research, Research Signpost, Trivandrum: 23–67.
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). Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd. Phytochemistry. 75, 99-107.
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Nazeerullah Khan, Ennus Tajuddin Tamboli, V.K. Sharma and Sunil Kumar
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Marcin Ożarowski, Jędrzej Przystanowicz and Artur Adamczak
Preparations from rhizomes of Petasites hybridus (L.) Gaertn., B. Mey. & Scherb. (common butterbur) have a long history of use in folk medicine in treatment of several diseases as anti-inflammatory and spasmolytic drugs. Extracts from this species are of interest to researchers in the field of phytopharmacology due to their biologically active compounds, particularly two eremophilane sesquiterpenes (petasin and isopetasin), which are contained not only in rhizomes and roots, but also in leaves. Moreover, P. hybridusa contains pyrrolizidine alkaloids, which showed hepatotoxic, carcinogenic and mutagenic properties. Hence, special extracts devoid of alkaloids obtained by sub- and super-critic carbon dioxide extraction were used in the preclinical, clinical studies and phytotherapy. Our review aims to provide a literature survey of pharmacological as well as clinical trials of P. hybridus, carried out in 2000-2013. Also several studies of other species used in non-European countries have been included. Besides, the botanical description of Petasites genus and phytochemical characteristic of P. hybridus and toxicological studies of pyrrolizidine alkaloids as well as chemical profile of patented commercial extracts from rhizomes, roots and leaves of this species used in European phytotherapy have been performed. In this review, attention has also been paid to the promising and potential application of special extracts of P. hybridus not only in the prevention of migraine, treatment of allergic rhinitis symptoms, asthma and hypertension, but also in prevention and slowing the progression of neurodegenerative diseases developing with the inflammatory process in the CNS as a new therapeutic strategy. In fact, there is already an evidence of promising properties of P. hybridus extracts and sesquiterpens - decrease in the prostaglandins and leukotrienes release, inhibition of COX-1 and COX-2 activity, as well as antagonism of L-type voltage-gated calcium channels. In order to explain the new mechanisms of action of P. hybridus extracts in the CNS and their future application in phytotherapy of diseases with neuroinflammatory process, further studies should be performed.
Yogini Jaiswal, Pratima Tatke, Satish Gabhe and Ashok Vaidya
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The present work focuses on an ethnobotanical study of medicinal plants in the Belezma National Park (BNP), which is located in Batna city. It was conducted to precise on the medicinal plants in the park and gathers all the information on the therapeutic practice used by the local inhabitants of the study area. Using 300 questionnaire cards, ethnobotanical surveys of BNP were conducted during two campaigns (2017 and 2018). The obtained results allowed us to identify 50 medicinal plants used by the population of the region, which are divided into 27 families and 46genus.
The obtained results show both leaves and stems are mostly used for diseases’ treatment in the form of a decoction with a rate of 42.34%. For the treated diseases, the digestive disorders occupy the first place with a rate of 34.01%, followed by uro-genital diseases with a rate of 17.56%, 11.20% for respiratory diseases, 11.84% for orthopedic diseases and 6.23% for cardiovascular.
The founded results could be a database for research on phytochemistry and pharmacology for the national medicinal flora and the population of the BNP region. Also, they constitute a very valuable source of information.
Arne J. Aasen, Sven-Olof Almquist and Curt R. Enzell
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