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vybrane metabolicke ochorenia (pp 756-767). P+M, Martin. Krahulec B, Klimeš I, Fabryova Ľ (2009) Algoritmy liečby 2: 3-13. Krauss RM (1995) American Journal of Cardiology 75: 53-57. Kumar A, Singh V (2010) Vascular Health and Risk Management 6: 665-669. Kuntic V, Pejic N, Ivkovic B (2007) Journal of Pharmaceutical and Biomedical Analysis 43: 718-721. Lacueva CA, Remon AM, Llorach R, Sarda UM, Khan N, Blanch GC, Ros ZR, Ribalta RM, Raventos RML (2011). In: Rosa LA, Parilla EA, Aguilar GAG Fruit and Vegetable Phytochemicals, Vol 1 (53-88). Wiley-Blackwel, USA. Lam KSL, Xu

REFERENCES [1] Sarkar, S.D., and Nahar, L. 2007. Chemistry for pharmacy students General, Organic and Natural Product Chemistry. England: John Wiley and Sons. Pp. 283-359. [2] Abo, K.A., Ogunleye, V.O., and Ashidi, J.S. 1991. Antimicrobial potential of Spondias mombin, croton zambesicus and Zygotritonia crocea. Journal of Pharmacological Research. 5(13): 494-497. [3] Liu, R.H., 2004. Potential synergy of phytochemicals in cancer prevention: mechanism of Action. Journal of Nutrition. 134(12):3479-3485. [4] Nweze, E.L., Okafor, J.l and Njoku O. 2004. Antimicrobial

References [1]. S.P. Bako, M.J. Bakfur, I. John, E.I. Bala, Ethnomedicinal and phytochemical profile of some savanna plant species in Nigeria, International Journal of Botany 1 (2005) 147-150. [2]. A. Sofowora, Medicinal plants and traditional medicine in Africa, 2nd edition, pp. 134 - 156, Spectrum Books Limited, Ibadan, Nigeria, 1993. [3]. F.B. Salisbury, C.W. Ross, Plant Physiology. pp. 357-407, Wadsworth, 1992. [4] World Health Organization, Traditional medicine - growing needs and potentials, WHO Policy Perspectives, 2002. [5]. Food and Agriculture

References [1]. D.S.H. Gracelin, A.J.D. Britto, P.B.Y.R. Kumar, Qualitative and quantitative analysis of phytochemicals in five Pteris species, International Journal of Pharmacy and Pharmaceutical Sciences 5 (2012) 105-107. [2]. N.A. Imaga, G.O. Gbenle, V.I. Okochi, S. Adenekan, T. Duro-Emmanuel, B. Oyeniyi, A.A. Kayode, O.T. Kayode, A.A. Odetola, Antiulcerogenic activity of two extracts of Parquetina nigrescens and their effects on mucosal antioxidants defense system on ethanol-induced ulcer in rats, Research Journal of Medicinal Plant 3 (2009) 102–108. [3

REFERENCES 1. Marczyński Z, Nowak S, Jambor J, Zgoda MM. Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility. Herba Pol 2016; 62(4):49-65. doi: http://dx.doi.org/10.1515/hepo-2016-0022 2. Schütz K, Carle R, Schieber A. Taraxacum – a review on its phytochemical and pharmacological profile. J Ethnopharmacol 2006; 107(3):313-323. doi: http://dx.doi.org/10.1016/j.jep.2006.07.021 3. Nowak E, Nachajski MJ, Zgoda MM

-0022 29. Marczyński Z, Fornal ME, Jambor J, Zgoda MM. Formulation and profile of pharmaceutical availability from model oral solid from of a phyto-chemicals contained in dry Taraxacum officinale extract. Herba Pol 2016; 62(4):66-81. doi: http://dx.doi.org/10.1515/hepo-2016-0023 30. Fedors RF. A method for estimating both the solubility parameters and molar volumes of liquids. Polymer Engineering and Science 1974; 14(2):147-154.

Abstract

Background and aims: monomethyl branched chain fatty acids (mmBCFA) and phytochemicals including: Hydroxycitric Acid, Chlorogenic Acid and Piperine have been considered as an interesting agent for researches due to their role in diabetes and cancer. The present study examines the antiglycation effect of mmBCFA and phytochemicals and investigate their Synergistic effect on different colorectal cancer cell lines.

Methods: This study was carried out by using murine monocyte-macrophage cell line and Methylglyoxal (MGO) to enhance the glycation process, furthermore to examine the antiproliferative effect of both the mmBCFA and phytochemicals we use Sulforhodamine B (SRB) assay against obesity related-colorectal cancer cell line panel.

Results: Both phytochemicals and mmBCFA have a higher antiglycation effect than Aminoguanidine (AMG) significantly, moreover, all of the phytochemicals and mmBCFA have antiproliferative against SW620, CACO2 and SW480, nevertheless none of these agents was equipotent to Cisplatin, furthermore, the synergetic effect observed only when we co-incubate Piperine with mmBCFA.

Conclusions: phytochemicals such as Hydroxycitric Acid, Chlorogenic Acid and Piperine and mmBCFA could be used as treatment to prevents the accumulation of advanced glycation end-products (AGEs) in diabetes. Furthermore, the co-incubation between these compounds can inhibit cancer growth, as alternative therapeutic strategy against obesity related-colorectal cancer.

capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility. Herba Pol 2016; 62(4):49-65. doi: http://dx.doi.org/10.1515/hepo-2016-0022 27. Marczyński Z, Fornal ME, Jambor J, Zgoda MM. Formulation and profile of pharmaceutical availability from a model oral solid form of a drug of phytochemicals contained in dry Taraxacum officinale extract. Herba Pol 2016; 62(4):66-81. doi: http://dx.doi.org/10.1515/hepo-2016-0023 28. Medić-Śarić M, Rendic Ś, Vestemar V

REFERENCES Adamu, H.M., Abayeh, O.J. & Agho, M.O. (2007). Phytochemical screening and antimicrobial activity of the extracts of Delarium microcarpum and Ziziphus mucronata . Nigerian Journal of Botany , 20(2): 327-334. Alan, R. (2014). The effect of nitrogen nutrition on growth, chemical composition, and response of cucumbers to N forms in solution culture. J.Hort.Sci., 6(4): 467-474, https://doi.org/10.1080/14620316.1989.11515979 Albuquerque, C.C., Camara, T.R., Mariano, R.L.R., Willadino, L., Marcelino, C. & Ulisses, C., (2006). Antimicrobial action

REFERENCES ABDEL-AAL, E.-S.M. – RABALSKI, I. 2008. Bioactive compounds and their antioxidant capacity in selected primitive and modern wheat species. In The Open Agriculture Journal , vol. 2 , no. 9, pp. 7–14. DOI: 10.2174/1874331500802010007 ADOM, K.K. – LIU, R.H. 2002. Antioxidant activity of grains. In Journal of Agricultural and Food Chemistry , vol. 50 , no. 21, pp. 6182–6187. DOI: 10.1021/jf0205099 ADOM, K.K. – SORRELLS, M.E. – LIU, R.H. 2005. Phytochemical and antioxidant activity of milled fractions of different wheat varieties. In Journal of