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REFERENCES 1. Marczyński Z, Nowak S, Jambor J, Zgoda MM. Solubility and solubilizing capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility. Herba Pol 2016; 62(4):49-65. doi: http://dx.doi.org/10.1515/hepo-2016-0022 2. Schütz K, Carle R, Schieber A. Taraxacum – a review on its phytochemical and pharmacological profile. J Ethnopharmacol 2006; 107(3):313-323. doi: http://dx.doi.org/10.1016/j.jep.2006.07.021 3. Nowak E, Nachajski MJ, Zgoda MM
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Background and aims: monomethyl branched chain fatty acids (mmBCFA) and phytochemicals including: Hydroxycitric Acid, Chlorogenic Acid and Piperine have been considered as an interesting agent for researches due to their role in diabetes and cancer. The present study examines the antiglycation effect of mmBCFA and phytochemicals and investigate their Synergistic effect on different colorectal cancer cell lines.
Methods: This study was carried out by using murine monocyte-macrophage cell line and Methylglyoxal (MGO) to enhance the glycation process, furthermore to examine the antiproliferative effect of both the mmBCFA and phytochemicals we use Sulforhodamine B (SRB) assay against obesity related-colorectal cancer cell line panel.
Results: Both phytochemicals and mmBCFA have a higher antiglycation effect than Aminoguanidine (AMG) significantly, moreover, all of the phytochemicals and mmBCFA have antiproliferative against SW620, CACO2 and SW480, nevertheless none of these agents was equipotent to Cisplatin, furthermore, the synergetic effect observed only when we co-incubate Piperine with mmBCFA.
Conclusions: phytochemicals such as Hydroxycitric Acid, Chlorogenic Acid and Piperine and mmBCFA could be used as treatment to prevents the accumulation of advanced glycation end-products (AGEs) in diabetes. Furthermore, the co-incubation between these compounds can inhibit cancer growth, as alternative therapeutic strategy against obesity related-colorectal cancer.
capabilities of aqueous solutions of Extractum Taraxaci e radix cum herba aqu. siccum in light of selected values of general Hildebrand-Scatchard-Fedors theory of solubility. Herba Pol 2016; 62(4):49-65. doi: http://dx.doi.org/10.1515/hepo-2016-0022 27. Marczyński Z, Fornal ME, Jambor J, Zgoda MM. Formulation and profile of pharmaceutical availability from a model oral solid form of a drug of phytochemicals contained in dry Taraxacum officinale extract. Herba Pol 2016; 62(4):66-81. doi: http://dx.doi.org/10.1515/hepo-2016-0023 28. Medić-Śarić M, Rendic Ś, Vestemar V
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