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A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations

, Development and evaluation of an enzyme immunoassay for sulfamerazine in milk, J. Agric. Food Chem. 42 (1994) 1379--1391; DOI: 10.1021/jf00042a026. M. S. Pena, F. Salinas, M. C. Mahendero and J. J. Aaron, Spectrofluorimetric determination of sulphonamides in pharmaceutical compounds and foods, J. Pharm. Biomed. Anal. 10 (1992) 805--808; DOI:10.1016/0731-7085(91)80084-M. Y. M. Issa, A. L. El. Ansary and W. Selim, Enthalpimetric determination of sulfa drugs in pure form and pharmaceutical formulations, Anal. Lett. 31

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Optimized and validated flow-injection spectrophotometric analysis of topiramate, piracetam and levetiracetam in pharmaceutical formulations

pharmaceutical formulation, Int. J. Pharm. Tech. Res.   2 (2010) 201-204. Y. S. I. El-Saharty, Simultaneous determination of piracetam and vincamine by spectrophotometric and high-performance liquid chromatographic methods, J. AOAC Int.   91 (2008) 311-321. F. H. Metwally, B. A. Elzeany and H. W. Darwish, New methods for determination of cinnarizine in mixture with piracetam by spectrodensitometry, spectrophotometry, and liquid chromatography, J. AOAC Int.   88 (2005) 1666-1676. G. Saravanan, G

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Development and validation of spectrophotometric methods for determination of ceftazidime in pharmaceutical dosage forms

Development and validation of spectrophotometric methods for determination of ceftazidime in pharmaceutical dosage forms

Two spectrophotometric methods for the determination of ceftazidime (CFZM) in either pure form or in its pharmaceutical formulations are described. The first method is based on the reaction of 3-methylbenzothiazolin-2-one hydrazone (MBTH) with ceftazidime in the presence of ferric chloride in acidic medium. The resulting blue complex absorbs at λmax 628 nm. The second method describes the reaction between the diazotized drug and N-(1-naphthyl)ethylenediamine dihydrochloride (NEDA) to yield a purple colored product with λmax at 567 nm. The reaction conditions were optimized to obtain maximum color intensity. The absorbance was found to increase linearly with increasing the concentration of CFZM; the systems obeyed the Beer's law in the range 2-10 and 10-50 μg mL-1 for MBTH and NEDA methods, resp. LOD, LOQ and correlation coefficient values were 0.15, 0.79 and 0.50, 2.61. No interference was observed from common excipients present in pharmaceutical formulations. The proposed methods are simple, sensitive, accurate and suitable for quality control applications.

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Determination of donepezil hydrochloride in human plasma and pharmaceutical formulations by HPLC with fluorescence detection

. Kafkala, S. Matthaiou, P. Alexaki, M. Abatzis, A. Bartzeliotis and M. Katsiabani, New gradient high-performance liquid chromatography method for determination of donepezil hydrochloride assay and impurities content in oral pharmaceutical formulation, J. Chromatogr. A   1189 (2008) 392-397; DOI: 10.1016/j.chroma.2007.12.015. H. Pappa, R. Farrú, P. O. Vilanova, M. Palacios and M. T. Pizzorno, A new HPLC method to determine donepezil hydrochloride in tablets, J. Pharm. Biomed. Anal.   27 (2002) 177-182. B. S. Sultry

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Spectrofluorimetric determination of gemifloxacin mesylate and linezolid in pharmaceutical formulations: Application of quinone-based fluorophores and enhanced native fluorescence

methods for the determination of gemifloxacin mesylate in pure form and pharmaceutical formulations, Anal. Chem: Indian J. 9 (2010) 129-136. 11. M. V. Krishna and D. G. Sankar, Utility of s and p-acceptors for the spectrophotometric determination of gemifloxacin mesylate in pharmaceutical formulations, E-J. Chem. 5 (2008) 493-498; DOI: 10.1155/2008/801545. 12. S. E. K. Tekkeli and A. Önal, Spectrofluorimetric methods for the determination of gemifloxacin in tablets and spiked plasma samples, J. Fluoresc. 21 (2011) 1001-1007; DOI: 10

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Ionophore-based potentiometric PVC membrane sensors for determination of phenobarbitone in pharmaceutical formulations

, H. Hassib, Y. Issa and S. Mohammed, Surface morphology changes of polymer membrane and carbon paste sertraline sensors, Talanta 134 (2015) 546-553; DOI: 10.1016/j.talanta.2014.11.018. 17. M. M. Hefnawy, A. M. Homoda, M. A. Abounassif, A. M. Alanazi, A. Al-Majed and G. A. Mostafa, Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors, Chem. Cent. J. 8 (2014) 59; DOI: 10.1186/s13065-014-0059-y. 18. J. L. Lima, M. C. B. Montenegro and A. R. Da Silva, A phenobarbital ion

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Comparison of two RP-HPLC methods for determination of recombinant human thrombin in pharmaceutical formulations. / Porovnanie dvoch RP-HPLC metód pre stanovenie rekombinantného ľudského trombínu vo farmaceutických formuláciách

Abstract

Two reversed-phase high performance liquid chromatography analytical methods (Method I and Method II) for determination of assay of recombinant human thrombin in pharmaceutical formulations were developed and validated. Analysis was performed on chromatographic system Agilent 1200 series SL with diode array detection and mass selective detection.

Method I was intended for faster determination of thrombin assay. Gradient programme was optimised to achieve sufficient separation and acceptable runtime. Chromatographic analysis was performed on analytical column Grace Vydac, C4 250 × 4.6 mm, 5 mm. Method II is Method I adapted to use the mass selective detector. Chromatographic separation was performed on analytical column Zorbax 300SB-C8 SolvSaver Plus, 150 × 3 mm, 3.5 mm. Both analytical methods were validated with respect to specificity, linearity, precision and accuracy. The response of thrombin was a linear function of concentration over the range 0.1-1.0 mg/ml. Precision and accuracy of thrombin was evaluated at three concentration levels low (0.2 mg/ml), medium (0.4 mg/ml) and high (0.8 mg/ml).

Both validated methods have been successfully applied for determination of assay and thrombin degradation products in pharmaceutical formulations.

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Comparison of high-performance thin layer chromatography/UV-densitometry and UV-derivative spectrophotometry for the determination of trimetazidine in pharmaceutical formulations

, Metabolism 65 (2016) 122–130; https://doi.org/10.1016/j.metabol.2015.10.022 5. A. Onay-Besikci and S. A. Özkan, Trimetazidine revisited: A comprehensive review of the pharmacological effects and analytical techniques for the determination of trimetazidine, Cardiovasc. Ther. 26 (2008) 147–165; https://doi.org/10.1111/j.1527-3466.2008.00043.x 6. T. K. Murthy, G. D. Sankar and S. R. Yarraguntla, Visible spectrophotometric methods for the determination of trimetazidine dihydrochloride in pharmaceutical formulations, Indian Drugs 39 (2002) 230

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Letrozole Determination by Capillary Zone Electrophoresis and UV Spectrophotometry Methods

Chem. 2010; 398:29-52. 21. Zarghi A, Foroutan SM, Shafaati A, Khoddam A. - HPLC Determination of Letrozole in Plasma Using Fluorescence Detection: Application to Pharmacokinetic Studies. Chromatographia. 2007;66: 747-750. 22. Mondal N, Pal TK, Ghosal SK - Development and validation of RP-HPLC method to determine letrozole in different pharmaceutical formulations and its application to studies of drug release from nanoparticles. Acta Pol Pharm. 2009;66:11-17. 23. Shao R, Yu LY, Lou HG, Ruan ZR, Jiang B, Chen JL

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Spectrofluorimetric method for atenolol determination based on gold nanoparticles

-spectrofluorimetric method for the direct determination of atenolol in human urine, Luminescence 29 (2013) 225–229; https://doi.org/10.1002/bio.2532 4. A. Bavili-Tabrizi, F. Bahrami and H. Badrouj, A very simple and sensitive spectrofluorimetric method based on the oxidation with cerium(IV) for the determination of four different drugs in their pharmaceutical formulations, Pharm. Sci. 23 (2017) 50–58; https://doi.org/10.15171/ps.2017.08 5. Y. Jiang, N. N. Horimoto, K. Imura, H. Okamoto, K. Matsui and R. Shigemoto, Bioimaging with two-photon-induced luminescence from

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