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peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. Free Radic Biol Med 2009, 46, 146–153. 4. David E., Tanguy A., Moraga D.: Peroxiredoxin 6 gene: a new physiological and genetic indicator of multiple environmental stress response in Pacific oyster Crassostrea gigas. Aquat Toxicol 2007, 84, 389–398. 5. De Zoysa M., Ryu J.H., Chung H.C., Kim C.H., Nikapitiya C., Oh C., Kim H., Saranya Revathy K., Whang I., Lee J.: Molecular characterization, immune responses and DNA protection activity of rock bream (Oplegnathus fasciatus

References 1. Benipal B., Feinstein S.I., Chatterjee S., Dodia C., Fisher A.B.: Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia. Redox Biol 2015, 4, 321–327. 2. Chatterjee S., Feinstein S.I., Dodia C., Sorokina E., Lien Y.C., Nguyen S., Debolt K., Speicher D., Fisher A.B.: Peroxiredoxin 6, phosphorylation, and subsequent phospholipase A 2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages. J Biol Chem 2011, 286

characterization and differential expression analysis of peroxiredoxin 6 from Ovis aries . Vet Immunol Immunopathol 2015, 164, 208–219. Liu N.N. Liu Z.S. Lu S.Y. Hu P. Li Y.S. Feng X.L. Zhang S.Y. Wang N. Meng Q.F. Yang Y.J. Full-length cDNA cloning, molecular characterization and differential expression analysis of peroxiredoxin 6 from Ovis aries Vet Immunol Immunopathol 2015 164 208 219 13 Liu N.N., Liu Z.S., Lu S.Y., Hu P., Zhang Y., Fu B.Q., Li Y.S., Zhou Y., Zhang Y., Ren H.L.: Isolation and characterisation of peroxiredoxin 6 promoter from sheep Ovis aries J Vet Res

tumor apoptosis-related genes, such as Lama3 , Lamb3 , Tumor Necrosis Factor ( TNF ), and Human chorionic gonadotropin-beta ( hCGB ). Proteomics methods have been adopted to analyze the impact of adult ESP on the protein expression in the cholangiocarcinoma cell line. The expression of 83 proteins was found to be affected. Among these proteins, thioredoxin 1 (Trxl) and peroxiredoxin 6 (Prdx6) help maintain the stability of cell redox and scavenge peroxides in the body. In various malignant tumors, expression is related to the occurrence and progression of tumor [ 33