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. (2002). Identification of a nuclear Stat1 protein tyrosine phosphatase, Molecular and Cellular Biology 22(16): 5662-5668. Janeway C. (2001). Immunobiology 5: The Immune System in Health and Disease , Garland, New York. Kalvakolanu D.V. (2003). Alternate interferon signaling pathways, Pharmacology & Therapeutics 100: 1-29. Levy D.E. and J. Darnell Jr. (2002). STATs: Transcriptional control and biological impact, Nature Reviews Molecular Cell Biology 3: 651-662. Lipniacki T., P. Paszek A.R. Brasier B. Tian H.-Q. Wang B.Luxon and M. Kimmel (2006). Stochastic

Jong, H. (2002). Modeling and simulation of genetic regulatory systems: A literature review, Journal of Computational Biology   9 (1): 67-103. DiStefano, J. J. (1981). Optimized blood sampling protocols and sequential design of kinetic experiments, American Journal of Physiology   9 (240): R259-R265. Fedorov, V. V. (1972). Theory of Optimal Experiments , Academic Press, New York, NY. Fujarewicz, K. (2007). Planning identification experiments for cell signaling pathways using sensitivity analysis, Proceedings of the 23rd IFIP Conference on System Modelling and

, to determine the changes in expression of relevant signalling molecules. Protein expression was visualised by enhanced chemiluminescence reagents (Thermo Fisher Scientific). Relative quantification of cyclin expression was determined by the width of the slip in Western blot. Evaluation of DNA damage pathway as related to PEDV infection . Phospho-specific antibodies for each molecule of interest in the pathway were used in this experiment, and the relative phosphorylation content of the major signalling molecules was detected by Western blot. Additionally

., “Pathview: an R/Bioconductor package for pathway-based data integration and visualization,” Bioinformatics , vol. 29, no. 14, pp. 1830-1831, Jul. 2013. 10. von Mering, C. et al. , “STRING: known and predicted protein-protein associations, integrated and transferred across organisms,” Nucleic Acids Res. , vol. 33, no. Database issue, pp. D433-D437, Dec. 2005. 11. Pectasides, D., Pectasides, E., and Economopoulos, T., “Fallopian tube carcinoma: a review.,” Oncologist , vol. 11, no. 8, pp. 902-12, Sep. 2006. 12. Chen, S., Einspanier, R., and Schoen, J., “Long

  4 : 488-493. Levy, D. E. and Darnell Jr., J. (2002). Stats: Transcriptional control and biological impact, Nature Reviews Molecular Cell Biology   3 : 651-662. Kalvakolanu, D. V. (2003). Alternate interferon signaling pathways, Pharmacology & Therapeutics   100 : 1-29. Hoeve, J. D., Ibarra-Sanchez, J., Fu, Y., Zhu, W., Tremblay, M., David, M. and Shuai, K. (2002). Identification of a nuclear stat1 protein tyrosine phosphatase, Molecular and Cellular Biology   22 (16): 5662-5668. Shuai, K. and Liu, B. (2003). Regulation of JAK-STAT signalling in the immune


The purpose of this paper is to describe water circulation patterns for selected lakes found along the Baltic coast in northern Poland and to determine primary recharge mechanisms or pathways that produce an influx or loss of lake water. A secondary purpose of the paper is to determine the magnitude of recharge for each studied source of water – river water influx, surface runoff from direct catchments, forced influx from polders surrounding lakes, and periodic marine water intrusions from the nearby Baltic Sea. It is also important to determine the magnitude of water outflow from lakes to the sea via existing linkages as well as to compare horizontal influx and outflow data. The study area consisted of five lakes located along the Baltic Sea in northern Poland: Łebsko, Gardno, Bukowo, Kopań, Resko Przymorskie. The main driving force of the studied lakes are large rivers that drain lake catchment areas and periodic brackish water intrusions by the Baltic Sea.

References [1] Alami N, Page V, Yu Q, Jerome L, Paterson J, Shiry L, Leyland-Jones B. Recombinant human insulin -like growth factor- binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models. Growth Horm IGF Res 2008; 18: 487-496. [2] Akkiprik M, Hu L, Sahin A, Hao X, Zhang W. The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer. BMC Cancer 2009; 9: 103. doi:10.1186/1471-2407-9-103 [3] Attias-Geva ZA, Bentov I, Ludwig DL , Fishman A , Bruchim I, Werne H. Insulin

a Reliable Answer? Review of Income and Wealth 55(1): 128-165. Kronig, Winfried. 2007. Die systematische Zufälligkeit des Bildungserfolgs. Bern: Haupt Verlag. Laganà, Francesco, Julien Chevillard, and Jacques-Antoine Gauthier. 2014. Socio-economic Background and Early Post-compulsory Education Pathways: A Comparison between Natives and Second- Generation Immigrants in Switzerland. European Sociological Review 30(1): 18-34. Loury, Glenn. 2002. The Anatomy of Racial Equality. Cambridge, MA: Harvard University Press. Meyer, Thomas. 2003. Parcours vers les formations

in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90 (2): 770–774. Lin SL, Chang D, Ying SY. (2005). Asymmetry of intronic pre-miRNA structures in functional RISC assembly. Gene 356 : 32–38. Long X, Miano JM. (2011). Transforming growth factor-beta1 (TGF-beta1) utilizes distinct pathways for the transcriptional activation of microRNA 143/145 in human coronary artery smooth muscle cells. Journal of Biological Chemistry 286 (34): 30119–30129. Ludlum DB, Tong WP, Mehta JR, Kirk MC, Papirmeister B. (1984). Formation of O6

, Villegas-Comonfort S, Cortes-Reynosa P, Salazar EP. Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. Prostaglandins Leukotrienes & Essential Fatty Acids. 2013;88(3):243-9. DOI: 10.1016/j. plefa.2012.12.003 34. Wang Z, Wang N, Han S, Wang D, Mo S, Yu L, et al. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. Plos One. 2013;8(7):e68566. DOI: 10.1371/journal.pone.0068566 35. Chun-Te C, Yi D, Hirohito Y, Jung-Mao H, Hsu-Ping K, Hortobagyi GN, et al