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The Effect of Dialysis Modality and Membrane Performance on Native Immunity in Dialysis Patients

.; Park, E.; Smith, M.; Goldman, M.; Elsayegh, S. Effects of parathyroid hormone on immune function. Clin. Dev. Immunol. 2010, 2010, doi:10.1155/2010/418695. 24. Ozdemir, F. N.; Yakupoglu, U.; Turan, M.; Arat, Z.; Karakayali, H.; Erdal, R.; Turan, M. Role of parathormone levels on T-cell response in hemodialysis patients. Transplant. Proc. 2002; 34: 2044–2045. 25. Angelini, D.; Carlini, A.; Giusti, R.; Grassi, R.; Mei, E.; Fiorini, I.; Mazzotta, L.; Antonelli, A. Parathyroid hormone and T-cellular immunity in uremic patients in replacement dialytic therapy

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Endocrine Dysfunction in Neurofibromatosis Type 1 – An Update

Abstract

Background: Neurofibromatosis type 1 is an autosomal dominant disorder associated with multiple neoplasms particularly those of ectodermal origin. Various endocrine pathologies are often present, among them, hyperparathyroidism and follicular thyroid lesion are very rare described and their coincidence in the same patient has not been described in the literature reviewed.

Subject: A 59-years-old woman with clinical manifestation of neurofibromatosis type 1 developed dysphagia, dysphonia, choking sensation. Physical and imagistic examination revealed a multinodular goiter with microfollicular lesion on fine needle aspiration biopsy (FNAB), elevated parathormone levels and severe osteoporosis. The surgically removed thyroid contained a nodule with follicular architecture of uncertain malignant potential; the parathyroid tissue appeared normal.

Discussion and conclusion: This case serves as a reminder to look for non-neurogenic tumors in patients with neurofibromatosis. Clinicians must be aware of the diverse clinical features of this genetic disorder.

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Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients

Abstract

Introduction. The study of dialysis patients not needing erythropoiesis-stimulating agents (ESA) for long periods of time has gained interest lately. The aim of this study was to compare laboratory and clinical parameters in hemodialysis patients with autosomal dominant polycystic kidney disease (ADPKD) treated or not with ESA. Methods. Forty-six hemodialysis ADPKD patients were studied for 8 months and they were divided into: group 1- 29 patients who received ESA during the study period and group 2- 17 patients with no ESA treatment. The following parameters were determined: weekly treatment time, body mass index (BMI), pre-session diastolic blood pressure (DBP), pre-session systolic blood pressure (SBP), blood volume processed (BVD), interdialytic body weight gain (IBWG), spKt/V -K/DOQI formula (Kt/V), urea distribution volume (UDV), hemoglobin (Hb), ferritin, transferrin saturation (TSAT), serum phosphate, total serum calcium, normalized protein catabolic ratio (nPCR), albumin, and intact parathormone (PTH). Results. Patients not requiring ESA were more likely to be men, had higher Hb, albumin, total serum calcium levels, IBWG, UDV, BVP, and weekly treatment time. They had lower ferritin, TSAT, SBP. There was no difference regarding DBP, BMI, serum phosphate, PTH, Kt/V, and nPCR. Conclusion. Hemodialysis ADPKD patients not treated with ESA seem to be better nourished, with a slightly better SBP control, with longer dialysis time and increased Hb (despite lower iron loading markers), compared to hemodialysis ADPKD patients treated with ESA.

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An Evaluation of the Levels of Vitamin D and Bone Turnover Markers After the Summer and Winter Periods in Polish Professional Soccer Players

Abstract

Vitamin D is synthesised in the skin during exposure to sunlight. The fundamental roles of vitamin D are the regulation of calcium and phosphate metabolism and bone mineralisation. Low vitamin D levels in athletes may adversely affect their exercise capabilities. The aim of our study was to investigate changes in serum levels of 25(OH)D3, calcium and bone turnover markers in football players in two training periods differing in the exposure to sunlight (after the summer period and after the winter period). We investigated 24 Polish professional soccer players. Serum levels of the following parameters were determined: 25(OH)D3, calcium, osteocalcin (OC), parathormone (PTH), procollagen type I N - terminal peptide (P1NP), and beta - CrossLaps (beta - CTx). We showed significantly higher levels of 25(OH)D3 and calcium and lower levels of PTH after the summer period versus the winter period. No significant differences in the levels of bone turnover markers were found. Furthermore, we did not observe any significant correlations between the levels of 25(OH)D3 and other parameters. Normal levels of 25(OH)D3 were observed in 50% of the players after the summer period and only in 16.7% of the players after the winter period. It is justified to measure the levels of 25(OH)D3, calcium and PTH in soccer players, especially after the winter period, when the exposure to sunlight is limited.

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Approximal Plaque Index, parameters of calcium-phosphate and iron metabolism and the quality of life of hemodialysis patients

Abstract

Introduction. Hemodialysis patients require high standards in the field of dental diseases prevention and also in pharmacological and dialysis methods of combating biochemical disorders. It is necessary to question the methods of monitoring oral hygiene quality among hemodialysis patients.

Aim. The aim of this study was to determine the relationship between Approximal Plaque Index (API) and the quality of life and biochemical parameters of the calcium, phosphate and iron metabolism.

Material and methods. The study was conducted on a group of 124 individuals – 65 women (52%) and 59 men (48%) aged 24-90, volunteered to undergo hemodialysis in chronic renal failure, who consented to participate in this study. All participants of the study were treated for at least 6 months, through repeated hemodialyses in dialysis centers in Lublin. The dental examination was performed and Approximal Plaque Index (API) was determined. The Polish version of the quality of life questionnaire SF-36 was used. The values of urea, serum creatinine concentration, serum level of calcium, serum phosphorus, parathormone, transferrin, ferritin, and iron were also under control. The Kruskal-Wallis H test and Spearman Rank Correlation was used.

Results. Patients with optimal API reported higher levels of iron and lowest concentration of transferrin and serum phosphorus before HD. Patients who were characterized by high levels of phosphate and parathyroid hormone evaluated their functioning in the emotional sphere as worse compared to others. Higher concentrations of iron and transferrin favor a better sense of the quality of life.

Conclusions. Lower concentrations of phosphate before hemodialysis and higher iron levels contribute to maintaining optimal interdental hygiene in patients treated with renal replacement therapy. Normalization of biochemical parameters of calcium-phosphate and iron metabolism promotes a sense of better quality of life among patients on chronic hemodialysis. The level of interdental hygiene does not distinguish between general indicators of the sense of quality of life.

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Radio-guided miniinvasive surgery of solitary parathyroid adenoma as a cause of primary hyperparathyroidism

preoperative SPECT 99mTc sestamibi scanning and intraoperative quick parathormone assay. Surgery 1997; 122: 1107–1114. 6) Elgazzar A. The pathophysiologic basis of nuclear medicine. Berlin, Springer 2001; Chap. 7, Parathyroid gland: 141–46. 7) Greenspan BS, Dillehay G, Intenzo C. SNM Practice Guideline for Parathyroid Scintigraphy. Journal of Nuclear Medicine Technology 2012; 40: 1-8. 8) Task Force on Primary Hyperparathyroidism. The American Association of Clinical Endocrinologists and the American Association of Endocrine Surgeons position statement on

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Late Onset of Multiple Basal Cell Carcinomas in a Patient with Gorlin-Goltz Syndrome Previously Treated for Hodgkin’s Lymphoma/ Kasna pojava multiplog bazocelularnog karcinoma kod pacijenta sa Gorlin-Golcovim sindromom prethodno lečenog od Hočkinovog limfoma

anomalies, medulloblastoma, and hyporesponsiveness to parathormone. Cancer 1965;18:89-104. 17. Jawa DS, Sircar K, Somani R, Grover N, Jaidka S, Singh S. Gorlin-Goltz syndrome. J Oral Maxillofac Pathol. 2009;13:89-92. 18. Patil KV, Mahima G, Gupta B. Gorlin syndrome: a case report. J Indian Soc Pedod Prev Dent. 2005;23:198-203. 19. Shivaswamy KN, Sumathy TK, Shyamprasad AL, Ranganathan C. Gorlin syndrome or basal cell nevus syndrome (BCNS): a case report. Dermatol Online J. 2010;16(9):6. 20. Kohli M, Kohli M

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Metabolic acidosis status and mortality in patients on the end stage of renal disease

lipoproteins (LDL) were measured by biochemical analysis and the ratio of LDL/HDL was calculated. Hematocrit and hemoglobin values were also measured. High sensitivity C-reactive protein (hsCRP) serum concentrations were measured using the enzyme linked immunosorbent assays ELISA, immundiagnostik AG, Germany) according to the manufacturer’s specifications. The concentrations of intact-parathormone (i-PTH) were measured by radioimmunoassay (CIS bio international/France). The serum bicarbonate concentrations were measured in gas machine (Roche, combas b 121) taking care of the

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CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

, Sayed D. Parathormone - 25(OH)-vitamin D axis and bone status in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes 2011; 12(6): 536-46. 47. Von Eynatten M, Hamann A, Twardella D, Nawroth PP, Brenner H, Rothenbacher D. Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease. Clin Chem 2006; 52(5): 853-9. 48. Goropashnaya AV, Herron J, Sexton M, Havel PJ, Stan - hope KL, Plaetke R, Mohatt GV, Boyer BB. Relationships

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Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism

Introduction Hypoparathyroidism is an endocrine disorder caused by insufficient parathormone (PTH) secretion or, very rarely, by PTH receptor resistance. The most frequent cause for parathyroidism in adults is the neck operations. It generally progresses with hypocalcemia, hyperphosphatemia, and low-normal PTH levels ( 1 ). While the electrolyte disorder developing in hypoparathyroidism has short-term symptomatic effects, there is also an increase in atherosclerosis and ischemic heart disease risks due to the pathological changes in the endothelium and

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