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VEGF expression in pancreatic cancer and other malignancies: a review of the literature

renal cell carcinomas. Pathol Res Pract. 2014 Dec; 210 (12):901-8. 72. AI K.X., LU L.Y., HUANG X.Y., CHEN W., ZHANG H.Z. Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer. World J Gastroenterol. 2008 Mar 28; 14 (12):1931-5. 73. VON MARSCHALL Z., CRAMER T., HÖCKER M., BURDE R., PLATH T., SCHIRNER M., HEIDENREICH R., BREIER G., RIECKEN E.O., WIEDENMANN B., ROSEWICZ S. De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop

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It’s Time for New Treatments in Pancreatic Cancer Pathology

References 1. Jamal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ . Cancer statistic, 2009. CA Cancer J Clin 59: 225-249, 2009. 2. Hsu C, Saif MW. Diabetes and pancreatic cancer. Highlights from the „2011 ASCO Annual Meeting” JOP 12: 330-333, 2011. 3. Huggett MT, Pereira SP . Diagnosing and managing pancreatic cancer. Practitioner 255: 21-25, 2-3, 2011. 4. DeCensi A, Puntoni M, Goodwin P et al . Metformin and cancer risk in diabetic patients: a systematic review and meta

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Phytotherapeutics oridonin and ponicidin show additive effects combined with irradiation in pancreatic cancer in vitro

Introduction Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States. 1 Surgical resection is still the most important treatment modality and prognostic factor, but in the late stage of the disease, only 10–20% of all primary tumours are still operable. 2 Beside primary metastasized and thus palliative stage IV disease 30-40% of all cases are locally advanced but non-metastasized tumors that could benefit from neoadjuvant treatment. 3 We recently reported that approximately one third of these locally advanced tumors

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Pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head with venous resection

Introduction In cases of pancreatic cancer pancreaticoduodenectomy with complete resection offers the only chance for cure. Historically, involvement of regional vascular structures by pancreatic carcinoma has been considered a contraindication for reconstruction. 1 At the time of diagnosis more than three quarters of patients have locally advanced disease or distant metastasis that preclude radical surgery and 5-year survival after “curative” surgery ranges from 10 to 20% even in recent large series. 2 Advances in surgical techniques, perioperative care

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Diffusion kurtosis imaging and conventional diffusion weighted imaging to assess electrochemotherapy response in locally advanced pancreatic cancer

Introduction Electrochemotherapy (ECT) is a promising tool for treatment of deep tumours. 1 , 2 , 3 , 4 , 5 , 6 This ablative technique combines the administration of chemotherapeutic drugs with electric pulses for cell membrane electroporation. 7 In our previous studies 6 , 7 , 8 , 9 , we demonstrated the safety and efficacy of the treatment in locally advanced pancreatic cancer. However, the correct assessment of the efficacy of ECT is a challenge for a radiologist since tumour necrosis is not always correlated with a dimensional change so that

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Paratesticular adenocarcinoma: unusual presentation of metastasis of pancreatic cancer

tumor: a metastasis from primary pancreas cancer. Scand J Urol Nephrol 2000; 34 : 70-1. Seo IY, Kim SG, Han WC, Rim JS. Paratesticular mucinous cystadenocarcinoma: metastasis from pancreatic cancer. Int J Urol 2004; 11: 1147-9. Dookeran KA, Lotze MT, Sikora SS, Rao UN. Pancreatic and ampullary carcinomas with intrascrotal metastases. Br J Surg 1997; 84 : 198-9. Mao C, Domenico DR, Kim K, Hanson DJ, Howard JM. Observations on the developmental patterns and the consequences of

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Physical Activity and Gastrointestinal Cancer Risk: A Review

Med Sci Sports. 2009;19(6):764-81. 7. Wen XY. Salt taste sensitivity, physical activity and gastric cancer. APJCP. 2010;11(6):1473-7. 8. Chen Y, Yu C, Li Y. Physical activity and risks of esophageal and gastric cancers: a meta-analysis. PloS one. 2014;9(2):e88082. 9. Farris MS, Mosli MH, McFadden AA et al. The Association between Leisure Time Physical Activity and Pancreatic Cancer Risk in Adults: A Systematic Review and Meta-analysis. Cancer Epidemiol, Biomarkers Prev. 2015;24(10):1462-73. 10. Nothlings U, Wilkens LR, Murphy SP et al. Body

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GSTP1 Ile105Val Polymorphism in Serbian Patients with Pancreatic Diseases

References Otsuki M, Tashiro M. Chronic pancreatitis and pancreatic cancer, lifestyle-related diseases. Intern Med 2007; 46: 109-13. Watanabe RM, Black MH, Xiang AH, Allayee H, Lawrence JM, Buchanan TA. Genetics of gestational diabetes mellitus and type 2 diabetes. Diabetes Care 2007; 30: S134-40. Ulrich AB, Schmied BM, Standop J, Schneider MB, Lawson TA, Friess H, et al. Differences in the expression of glutathione S-transferases in normal pancreas, chronic pancreatitis, secondary

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Sodium-glucose cotransporters: new targets of cancer therapy?

. Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival. Cancer Invest 2008;26:852-9. doi: 10.1080/07357900801956363 37. Hanabata Y, Nakajima Y, Morita K, Kayamori K, Omura K. Coexpression of SGLT1 and EGFR is associated with tumor differentiation in oral squamous cell carcinoma. Odontology 2012;100:156-63. doi: 10.1007/s10266-011-0033-2 38. Helmke BM, Reisser C, Idzkoe M, Dyckhoff G, Herold- Mende C. Expression of SGLT-1 in preneoplastic and neoplastic lesions of the head and neck. Oral Oncol 2004;40:28-35. doi

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Electrochemotherapy in pancreatic adenocarcinoma treatment: pre-clinical and clinical studies

Introduction Pancreatic adenocarcinoma, despite extensive research, remains one of the deadliest cancers with high mortality rate. Surgical resection represents the only curative treatment for this pathology, but the majority of the patients are incurable at initial presentation with metastatic (stage IV) or surgically non-resectable disease (stage III disease). 1 – 3 At present gemcitabine and paclitaxel (Abraxane) are the best chemotherapeutic agents used for treatment of pancreatic cancer, however, patients develop drug resistance over the time. Thus

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