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31 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 RADIOTHERAPY IN OSTEOSARCOMAS doi: 10.2478/rojost-2018-0042 R. Mitrică, L. Şerbănescu, O. Trifănescu “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Osteosarcoma represents a rare primary tumor of the bone, but it ranks 5th among children and adolescents. When diagnosed, many patients already have a disseminated disease at subclinical level. Current treatment includes surgery and chemotherapy. Radiotherapy is not commonly indicated

62 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 SURGICAL TREATMENT FOR PULMONARY METASTASES OF OSTEOSAR-COMA doi: 10.2478/rojost-2018-0073 I.M. Rădulescu Thoracic Surgery Department, University Emergency Hospital, Bucharest, Romania Introduction. Osteosarcomas represent 40% of bone sarcomas and occur mainly in children and young adults. They are tumors with a high degree of pulmonary metastasis. Pulmonary metastases occur in about 80% of the relapsed patients after primary tumor therapy, whether or not

References Bertoni F, Boriani S, Campanacci M. Periosteal osteosarcoma and periosteal chondrosarcoma. Two distinct entities. J Bone Joint Surg Br 1982; 64 : 370-6. Lichtenstein L. Bone tumors. 4 th edition. Saint Louis: CV Mosby Company; 1972. Scaglietti O, Calandriello CB. Ossifying parosteal osteosarcoma. Parosteal osteoma or juxtacortical osteogenic sarcoma. J Bone Joint Surg Am 1962; 44-A : 635-47. Thomas WB, Daniel GB, McGavin MD. Parosteal osteosarcoma of the cervical vertebra in a dog. Vet Radiol Ultrasound 1997; 38 : 120-3. Larsson SE

17 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 THE INDICATION OF RESECTION-RECONSTRUCTION WITH TUMOR PROSTHESIS FOR THE YOUNG PATIENT WITH OSTEOSARCOMA doi: 10.2478/rojost-2018-0028 A. Cursaru¹,², A.G. Lupu¹,², D. Anghelescu¹, G. Mardare¹, R. Ene¹,², C. Cîrstoiu¹,² 1 University Emergency Hospital, Bucharest,Romania 2”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Introduction. The osteosarcoma represents the most frequently encountered primitive malignant bone tumor, representing 30

References 1. Adem C, Reynolds C, Ingle JN, Nascimento AG. Primary breast sarcoma: Clinicopathologic series from the Mayo Clinic and review of the literature. Br J Cancer. 2004;91:237-41. 2. Young JL Jr, Ward KC, Wingo PA, Howe HL. The incidence of malignant non-carcinomas of the female breast. Cancer Causes Control. 2004;15:313-9. 3. Silver SA, Tavassoli FA. Primary osteogenic sarcoma of the breast. A clinicopathologic analysis of 50 cases. Am J Surg Pathol. 1998;22:925-33. 4. Brustugun OT, Reed W, Poulsen JP, Bruland OS. Primary osteosarcoma of the breast. Acta

References 1. Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004. Cancer 2009; 115: 1531-43. 2. Ostrowski ML, Johnson ME, Smith PD, Chevez- Barrios P, Spjut HJ. Low-grade intraosseous osteosarcoma with prominent lymphoid infiltrate. Arch Pathol Lab Med 2000; 124: 868-71. 3. Ragazzini P, Gamberi G, Benassi MS, Orlando C, Sestini R, Ferrari C, et al. Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. Cancer Detect Prev 1999; 23: 129-36. 4. Ellis JH, Siegel CL, Martel W, Weatherbee L

References 1. Rossi S, Fletcher CD. Angiosarcoma arising in hemangioma/vascular malformation: Report of four cases and review of the literature. Am J Surg Pathol. 2002; 26:1319-29. 2. O bana Y, Tanji K, Furuta I, Yamazumi T, Hashimoto S, Kikuchi H, Tanaka S, Ohba Y. A case of malignant transformation in thoracic vertebral hemangioma following repetitive irradiation and extraction. Pathol Int. 1996; 46:71-8. 3. Savage SA, Mirabello L. Using epidemiology and genomics to understand osteosarcoma etiology. Sarcoma. 2011; 2011:548151. 4. Ueno H, Ariji E, Tanaka T

References 1. Ritter J, Bielack SS. Osteosarcoma. Ann Oncol 2010; 21 Suppl 7: vii320-5. 2. Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res 2009; 152: 3-13. 3. Mirabello L, Yu K, Berndt SI, Burdett L, Wang Z, Chow - dhury S, et al. A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. BMC Cancer 2011; 11: 209. 4. Quartuccio N, Treglia G, Salsano M, Mattoli MV, Muoio B, Piccardo A, et al. The role of Fluorine-18-Fluoro - deoxyglucose positron emission tomography in staging and restaging of

activity, extent, and intensity of inflammatory processes. NSAIDs are commonly used in veterinary medicine not only because of their anti-inflammatory effect but also due to their analgaesic and antipyretic properties. However, their most interesting feature is their potential anticancer effect. Osteosarcoma is a primary malignant bone tumour of mesenchymal origin with a very diverse histological structure. Osteosarcoma is diagnosed in approximately. 80%–85% of dogs with bone cancer, making it the most common lesion in this group of tumours. Seen in the context of all

al. Lysophosphatidic acid acyltransferase β (LPAATβ) promotes the tumor growth of human osteosarcoma. PLoS ONE 2010; 5: e14182. 15. Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G. Primary bone osteosarcoma in the pediatric age: state of the art. Cancer Treat Rev 2006; 32: 423-6. 16. Kachanov DY, Dobrenkov KV, ShamanskayaTV, Abdullaev RT, Inushkina EV, Savkova RF et al. Solid tumors in young children in Moscow Region of Russian Federation. Radiol Oncol 2008; 42: 39-44. 17. Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, et al