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References 1. Awojobi O, Scott SE, Newton T . Patients’ perceptions of oral cancer screening in dental practice: a cross-sectional study. Bio Medical Central Oral Health , 2012; 12:55-63 2. Carter L, Ogden G . Oral cancer awareness of undergraduate medical and dental students. Bio Medical Central Medical Education , 2007; 7:44-51. 3. Charalambous C, Theodorou M . Systems for the provision of oral health care in the Black Sea Countries. Part 11: Cyprus. Oral Health and Dental Management , 2013; 12(1). March 4. Charalambous C, Maniadakis N, Polyzos N

, Khan AA, Ali SS. Genetic etiology of oral cancer. Oral Oncol, 2017;70:23-28. 10. Lin LH, Chang KW, Cheng HW, Liu CJ. SMAD4 Somatic Mutations in Head and Neck Carcinoma Are Associated With Tumor Progression. Front Oncol, 20199:1379. 11. De la Oliva J, Larque AB, Marti C, Bodalo-Torruella M, Nonell L, Nadal A et al. Oral premalignant lesions of smokers and non-smokers show similar carcinogenic pathways and outcomes. A clinicopathological and molecular comparative analysis. J Oral Pathol Med, 2019. doi: 10.1111/jop.12864 12. Shiboski CH, Shiboski SC, Silverman S Jr

Abstract

Radial forearm flap is a gold standard for oral soft tissue defect reconstruction after tumour ablative surgery of oral cancer in advanced stages. The main disadvantage of this flap is donor site morbidity. The goal of our study was to show versatility of lateral arm flap in 34 cases with different oral defects that were reconstructed after tumour ablation, and to analyse complications and donor site morbidity. Thirty-four patients with advanced stage oral cancer (T3 and T4) underwent tumour ablation with or without suspicious lymph node removal and with immediate reconstruction of oral defect with lateral arm flap. Analysis of complications and donor sites morbidity was carried out. The Michigan Hand Outcome Questionnaire was used to evaluate functional and esthetical donor site outcome during at least one year follow up. Thirty-one patients had successful free flap surgery with uneventful post-surgery period. Flap loss due to vascularity problems was in one case (2.9%). The flap success rate was 97.1%. The donor site was closed primarily in all cases and healed uneventfully. The Michigan Hand Outcome Score was average 94.30%. The lateral arm is an excellent choice for oral reconstruction after ablative tumour surgery. It is versatile, safe and reliable for oral reconstruction with very good functional and aesthetical donor site outcome.

malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol, 2009;45:317-323. 5. Hadzic S, Gojkov-Vukelic M, Pasic E, Dervisevic A. The significance of early detection of potentially malignant lesions in the prevention of oral cancer. Mater Sociomed, 2017;29(2):129-133. 6. Shidara R, Sreeshyla HS, Sudheendra US, Chemiluminescence: A diagnostic adjunct in oral precancer and cancer: A review. J Cancer Res Ther, 2014;10:487-491. 7. Burzynski NJ, Rankin KV, Silverman S Jr, Scheetz JP, Jones DL

References 1. Miloro M, Ghali GE, Larsen EP, Waite DP. Maxillofacial pathology. Peterson’s principles of oral and maxillofacial surgery. Second edition. BC Decker Inc; Hamilton: London, 2004:1461(563-723). 2. Neville WB, Day AT. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002; 52:195-215. 3. Messadi VD, Wilder-Smith P, Wolinsky L. improving oral cancer survival: The role of dental providers. J Calif Dent Assoc. 2009;37(11):789-798. 4. Huff K, Stark CP, Solomon WL. Sensitivity of direct tissue fluorescence visualization in screening for oral

Introduction Oral cancer prevalence is increasing, while the 5 year survival is about 50%. The patients who survive often develop chronic oral complications and functional abnormalities after their oncological therapy [ 1 , 2 , 3 , 4 ]. Pain in the mouth, jaw and neck, xerostomia/dry mouth, sticky saliva, radiation caries, fibrosis, difficulties in mouth opening and trismus are among the most common chronic complications. Those problems and functional abnormalities are associated with difficulties in food and liquid intake, swallowing problems, with the

xerostomia (dry mouth). Odontology , 2009; 97:76-83. 18. Glick M, Johnson NW . Oral and oropharyngeal cancer: what are the next steps? J Am Dent Assoc , 2011; 142:892-894. 19. Johnson NW, Warnakulasuriya KA . Epidemiology and aetiology of oral cancer in the United Kingdom. Community Dent Health , 1993; 10 (Suppl 1):13-29. 20. Nalçaci R, Erdemir EO, Baran I . Evaluation of the oral health status of the people aged 65 years and over living in near rural district of Middle Anatolia, Turkey. Arch Gerontol Geriatr , 2007; 45:55-64. 21. Kossioni AE, Kossionis GE

References 1. Pisani B, Bray F, Parkin DM. Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer 2002; 97: 72-81. 2. Silverman Jr S. Demographics and occurrence of oral and oropharyngeal cancers. The outcomes, the trends, the challenge. J Am Dent Assoc 2001; 132: 75-115. 3. Forastiere A, Koch W, Trotti A, Sidransky D. Head and neck cancer. N Engl J Med 2001; 345: 1890-900. 4. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin 2002; 52: 195-215. 5. Campo-Trapero J, Cano-Sanchez J, Palacios

, through general inflammatory effects and direct metabolism of chemical carcinogens [ 9 , 10 , 11 ]. Stimulants, in particular smoking, diseases such as diabetes, chronic stress and obesity are among the many factors that can disturb the symbiosis of bacterial flora. Dysbiotic oral microflora disrupts the host’s defense mechanisms, causing chronic periodontal disease or even oral cancer [ 12 , 13 , 14 ]. Just a few months ago, a study on the body’s immunity related to the dependence of malnutrition and the bacterial flora of the mouth and intestines was published

betel-quid chewing and the metabolic syndrome in men. Am J Clin Nutr., 83, 1153, 2006. 23. Yen A.M.F. et al.: A prospective community-population-registry based cohort study of the association between betel-quid chewing and cardiovascular disease in men in Taiwan (KCIS no. 19). Am J Clin Nutr., 87, 70, 2008. 24. Zhang X., Reichart P.A.: A review of betel quid chewing, oral cancer and precancer in Mainland China. Oral Oncol., 43, 424, 2007.