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References 1. Tomassen P., Van Zele T., Zhang et al. - Pathophysiology of chronic rhinosinusitis. Proc Am Thorac Soc., 2011;8(1):115-20. doi: 10.1513/ pats.201005-036RN. 2. Hobbs A.J., Ignarro L.J. - The nitric oxide-cyclic GMP signal transduction system. In: Zapol W.M., Bloch K.D., eds. - Nitric oxide and the lung. New York: Marcel Dekker, 1997;pp.1-57. 3. Lamas S., Michel T. - Molecular biological features of nitric oxide synthase isoforms. In: Zapol W.M., Bloch K.D., eds. - Nitric oxide and the lung. New York: Marcel Dekker, 1997;pp.59-73. 4. Förstermann U

pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach, Curr. Diabetes Rev. 7 (2011) 313-324; DOI: 10.2174/ 157339911797415585. 15. N. A. Terpolilli, M. A. Moskowitz and N. Plesnila, Nitric oxide: considerations for the treatment of ischemic stroke, J. Cereb. Blood Flow Metab. 32 (2012) 1332-1346; DOI: 10.1038/jcbfm.2012.12. 16. N. Toda and H. Toda, Coronary hemodynamic regulation by nitric oxide in experimental animals: recent advances, Eur. J. Pharmacol. 667 (2011) 41-49; DOI: 10.1016/j

References Abu-Soud HM, Ichimori K, Presta A, Stuehr DJ. (2000). Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase. J Biol Chem   275 : 17349-17357. Abu-Soud HM, Wang J, Rousseau DL, Fukuto JM, Ignarro LJ, Stuehr DJ. (1995). Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis. J Biol Chem   270 : 22997-23006. Aktan F. (2004). iNOS-mediated nitric oxide production and its regulation. Life Sci   75 : 639-653. Alderton WK, Cooper CE, Knowles RG

References 1. Persson MG, Gustafsson LE, Wiklund NP, Moncada S, Hedqvist P. Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiol Scand 1990;140(4):449-57. 2. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991;181(2):852-7. 3. Stuber T, Sartori C, Salmón CS, Hutter D, Thalmann S, Turini P, Jayet PY, Schwab M, Sartori-Cucchia C, Villena M, Scherrer U, Allemann Y

REFERENCES 1. M. Hoffman, A new role for gases: neurotransmission, Science 28 (1991) 1788–1788; https://doi.org/10.1126/science.1712121 2. S. Moncada, R. M. Palmer and E. A. Higgs, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43 (1991) 109–142. 3. K. S. Raevskii, V. G. Bashkatova and A. F. Vanin, The role of nitric oxide in brain glutaminergic pathology, Vestn. Ross. Akad. Med. Nauk 1 (2000) 11–15. 4. M. Banach, B. Piskorska, S. J. Czuczwar and K. K. Borowicz, Nitric oxide, epileptic seizures, and action of antiepileptic

References Chen CC, Tsai PC, Wei BL and Chiou WF. (2008) 8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages. Eur J Pharmacol   590 : 430-436. Choi Y, Lee MK, Lim SY, Sung SH and Kim YC. (2009) Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells. Br J Pharmacol   156 : 933-940. Cragg GM and Newman DJ. (2008) Detection, isolation and structural determination in

obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6. 5. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-6. 6. ElliottTG, Cockcroft JR, Groop PH, Viberti GC, Ritter JM. Inhibition of nitric oxide synthesis in forearm vasculature of insulin-dependent diabetic patients: Blunted vasoconstriction in patients with microalbuminuria. Clin Sci (Lond) 1993;85:687-93. 7. Tesfamariam B, Brown ML, Cohen RA. Elevated

Experimental Diabetes. Neurophysiology 49(3): 183-193, 2017. 7. Sklyarov AY, Detsyk OI. The changes of the activity of NO-synthases and oxidative processes under conditions of 5-HT receptors activation in the stomach and large intestine in streptozotocin-induced diabetes mellitus. Fiziol Zh 58(5): 22-27, 2012 8. Onori L, Aggio A, D’Alo S et al. Role nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats // Word. J. Gastrointestinal 11(36): 5677–5684, 2005. 9. Zandecki M, Vanden

References Bakker RA, Schoonus SB, Smit MJ, Timmerman H, Leurs R (2001) Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling. Mol Pharmacol   60 : 1133-1142. De Vos C (1999) H1-receptor antagonists: effects on leukocytes, myth or reality? Clin Exp Allergy   29 Suppl 3 : 60-63. Feelisch M, Kelm M (1991) Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells. Biochem Biophys Res Commun   180 : 286-293. Church

-107. Dowell FJ, Henrion D, Duriez M, Michel JB. (1996). Vascular reactivity in mesenteric resistance arteries following chronic nitric oxide synthase inhibition in Wistar rats. Br J Pharmacol 117: 341-346. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. (2002). Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76: 911-922. Ferrari AU, Daff onchio A, Albergati F, Bertoli P, Mancia G. (1990). Intra-arterial pressure alterations during tail-cuff blood pressure measurements in normotensive and hypertensive rats. J Hypertens 8: 909-911. Furchgott RF