Non Wongvittavas, Kamol Panumatrassamee, Julin Opanuraks, Manint Usawachintachit, Supoj Ratchanon, Kavirach Tantiwongse, Chanatee Bunyaratavej, Apirak Santi-ngamkun and Kriangsak Prasopsanti
1. Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med. 1996; 335:865-75.
2. La Vecchia C, Negri E, Levi F. Increasing incidence of renal cell cancer. JAMA. 1999; 282:2120-1.
3. Robson CJ, Churchill BM, Anderson W. The results of radical nephrectomy for renal cell carcinoma. J Urol. 2002; 167:873-5; discussion 6-7.
4. Bensalah K, Pantuck AJ, Crepel M, Verhoest G, Mejean A, Valeri A, et al. Prognostic variables to predict cancer-related death in incidental renal tumours
Hai-Feng Liu, Hui Li, Ge Bai, Qian-Zhen Zhang, Xiang-Gao, Tao Liu and Hong-Bin Wang
housed individually and fed a piglet diet (Shenzhen Jinxinnong Feed, China) and given tap water ad libitum . All pigs were preoperatively assessed as healthy after a physical examination and complete blood count.
Surgical procedure. The pigs were divided into three equal groups: a ⅔ group, a ¾ group, and a ⅚ group. Animals in the ⅔ group were subjected to a ⅓ left nephrectomy and a right radical nephrectomy, animals in the ¾ group had a ½ left nephrectomy and a right radical nephrectomy performed, and animals in the ⅚ group underwent a ⅔ left nephrectomy and a
Emma Aitken, Alex Vesey, Julie Glen, Mark Steven and Marc Clancy
1. Jacobs S, Cho E, Foster C, et al. Laparoscopic donor nephrectomy: The University of Maryland 6-year experience. The Journal of Urology 2004; 171(1): 47-51.
2. Flowers JL, Jacobs S, Cho E, et al. Comparison of open and laparoscopic live donor nephrectomy. Ann Surg 1997; 226 (4): 483-490.
3. London ET, Ho HS, Neuhaus AMC, et al. Effect of intravascular volume expansion on renal function during prolonged CO2 pneumoperitoneum. Ann Surg 2000; 231: 195-201.
4. Mishra J, Dent C, Tarabishi
Guy Sydney, Kalliopi Ioakim, Nayia Kara and George Pantelas
carcinoma in the head and neck: An evaluation of 22 cases in 671 patients. Int Braz J Urol, 2017;43:202-208.
9. Hussain F, Yedavalli N, Loeffler D, Kajdacsy-Balla A. Solitary parotid metastasis 8 years after a nephrectomy for renal cell carcinoma. J Community Hosp Intern Med Perspect, 2016; 6:31950.
10. Majewska H, Skálová A, Radecka K, Stodulski D, Hyrcza M, Stankiewicz C, et al. Renal clear cell carcinoma metastasis to salivary glands - a series of 9 cases: clinicopathological study. Pol J Pathol, 2016;1:39-45.
11. Balaban M, Vudali Dogruyol S, Idilman
Asada Leelahavanichkul, Wiwat Chancharoenthana and Somchai Eiam-Ong
sensitive biomarkers to improve CKD prevention programs.
For biomarker discovery, animal models of disease are important. A common rodent model of CKD is 5/6 nephrectomy in rats with ligation of the anterior division of the renal artery, and the natural history of this model is well-established [ 5 ]. However, the rat model induced by 5/6 nephrectomy has a closer resemblance to focal segmental glomerulosclerosis, may not a good representation of TI fibrosis. Because of the greater availability of genetic manipulation in mice compared with rats, a mouse model of TI
Background. The purpose of this paper is to present the epidemiology, diagnostic workup and treatment of renal cell carcinoma (RCC) with an emphasis on the Slovenian epidemiological data. RCC represents 2% of all cancers and is the third most common genitourinary tract tumour. It most frequently occurs among people of ages, between 50 and 60 years. Male patients are more prone to it than female. A number of environmental, occupational and genetic factors have been found to be associated with the development of RCC. Patients often have nonspecific symptoms and this is the reason why for half of them the disease is already metastatic when diagnosed. The most common sites of metastases are lungs (75%), followed by soft tissues (36%), bones (20%), liver (18%), skin (8%) and central nerve system (8%). In the evaluation of RCC multiple diagnostic procedures are needed with obligatory image diagnostics.
Conclusions. Radical nephrectomy is still the mainstream treatment of localized disease. Nephron sparing techniques have been used in cases, where radical operation would result in an anephric patient. Efficient adjuvant therapy has not been discovered yet. Until recently interpherone and interleukin were the only known effective treatments for metastatic disease, but now new and more efficient biologic agents are being discovered. The most important prognostic factor for survival is stage at the beginning of treatment. The 5-year survival rate is 95% for patients with stage I disease, 88% for stage II, 59% for stage III and 20% for stage IV.
Dariusz Waniczek, T. Kamiński, H. Augustyniak, D. Nadbrzeżna and A. Czarniecka
Thyroid gland is a rare site for distant metastases. The aim of this study is to present a rare case of an isolated metastatic clear cell renal cell cancer (ccRCC) in the thyroid gland seven years after left-sided nephrectomy.
A neck cancer discovered by clinical examination, diagnosed by ultrasound-guided USG fine-needle biopsy was removed by surgery. Palliative thyroidectomy with consecutive neck radiotherapy was finished without any complications, except a temporary, asymptomatic hypocalcaemia. After six month remission, the patient’s general condition deteriorated, multiorgan RCC dissection appeared leading to the patient’s death
Christian Bjerre Høyer, Leif Rognås, Lars Lund and Lene Warner Thorup Boel
A 63-year-old woman underwent a nephrectomy on the right side for renal cancer. Postoperatively she developed abdominal and lower back pain, which was treated with an injection of analgesics in an epidural catheter. The following morning it was discovered that the patient had cold legs with pallor and no palpable femoral pulse. Rigor mortis and livor mortis were diagnosed in both legs, even though the patient was still alive and awake. Doppler ultrasound examination revealed the absence of blood flow in the lower part of the abdominal aorta and distally. A cross disciplinary conference including specialists in urology, orthopaedics, vascular surgery, anaesthesiology, internal medicine, and intensive care concluded that no lifesaving treatment was possible, and the patient died the following day. A forensic autopsy revealed severe atherosclerosis with thrombosis and dissection of the abdominal aorta. This case clearly demonstrates that a vascular emergency should be considered when patients complain about pain in the lower back, abdomen or limbs. Clinicians should be especially aware of symptoms of tissue death that can be masked by epidural analgesia.
angiomyolipoma and polycythemia vera diagnosed by a point mutation in the gene for Janus kinase 2 ( JAK2 ) with outcome after partial nephrectomy.
A 59-year-old Thai woman, presented with a right abdominal mass and had suffered from abdominal discomfort for a few months. She had no history of underlying diseases, smoking or alcohol intake. She had facial flushing, dizziness, and anorexia. On physical examination, her respiratory and cardiovascular variables were within normal limits. A huge mass at her right upper abdomen was palpable and this was confirmed
Călin Molnar, Octavian-Sabin Tătaru, Lucian Mărginean and Angela Borda
1. Togral G, Arıkan M, Gungor S. Rare skeletal muscle metastasis after radical nephrectomy for renal cell carcinoma: evaluation of two cases. J Surg Case Rep . 2014;2014(10):rju101.
2. Sountoulides P, Metaxa L, Cindolo L. Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports. J Med Case Reports . 2011;5:429.
3. Shuch B1, Bratslavsky G, Linehan WM, Srinivasan R. Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. Oncologist . 2012