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References The Encyclopedia of Nanoscience and Nanotechnology. H. S. Nalwa [ed.], USA, 2004. h Yang H., Yang R., Wan X., Wan W.: Structure and photoluminescence of Ge nanoparticles with different sizes embedded in SiO 2 , glasses fabricated by a sol-gel method. J. Crystal Growth 261 (2004) 549-556.

JAI. 10. Franceschini, F., Galetto, M., & Maisano, D. (2007). Management by measurement: Designing key indicators and performance measurement systems . Torino: Springer Berlin Heidelberg. doi: 10.1007/978-3-540-73212-9 11. Geipele, I., Staube, T., Ciemleja, G., Geipele, S., Zeltins, N., & Ekmanis, J. (2015). The development and design of engineering economic indicator system for nanotechnology industry product manufacturing: A case study of Latvia. Latvian Journal of Physics and Technical Sciences, 52 (5) , 3–19. doi: 10.1515/lpts-2015-0024. 12. The Global

References 1. Schwab, K. (2016). The Global Competitiveness Report 2016-2017. World Economic Forum. Retrieved from 2. Geipele, I., Geipele, S., Štaube, T., Ciemleja, G., & Zeltiņš, N. (2016). The development of nanotechnologies and advanced materials industry in science and entrepreneurship: Socioeconomic and technical indicators: A case study of Latvia (Part One). Latvian Journal of Physics and Technical Sciences, 53(4), 3-13. ISSN 0868-8257. Available at doi: 10.1515/lpts-2016-0023 3

and Solutions. New York: Blackwell Publishing; 2003:51-54. [5] Bhushan B. Handbook of Nanotechnology. Berlin-Heidelberg, Germany: Springer-Verlag; 2004. [6] Rao C, Muller A, Cheetham AK. The Chemistry of Nanomaterials, Synthesis, Properties and Applications. Weinheim, Germany: Wiley-VCH; 2005. [7] Nalwa HS. Encyclopedia of Nanoscience and Nanotechnology. Valencia, CA, USA: American Scientific Publisher; 2004-2011. [8] Cheng CJ, Tietjen GT, Saucier-Sawyer JK, Saltzman WM. Nat Rev Drug Discov. 2015;14:239-247. DOI: 10.1038/nrd4503. [9] Rai M, Ribeiro C, Mattoso L

References Balcerzak, M. (2013). Zagadnienia nanotechnologii w prawie, Czy nanotechnologia może czerpać z doświadczeń biotechnologii? [The issues of nanotechnologies in law, Is nanotechnology can draw on the expertise of biotechnology?]. In D. M. Trzmielak (Ed.), Innowacje i komercjalizacja w biotechnologii [Innovation and commercialization in biotechnology], Poznań - Łodź, Poland: Uniwerstytet Łodzki. Baran, A. (2015). Prawne aspekty nanotechnologii w kontekście ochrony środowiska [Legal aspects of nanotechnology in environmental protection, Economics and

References 1. Coleman, K. G. (2002). Commercial evolution of nanotechnology. Nanotechnology, IEEE-NANO2002; Proceedings of the 2 nd IEEE Conference , 385-388. DOI: 10.1109/NANO.2002.1032271. 2. Staube, T., Ciemleja, G., & Geipele, I. (2014). (a) Nanoscience: the scale of Latvia. Advanced Materials Research, 1004 , 28-31. DOI: 10.4028/ 3. Nalwa, H. S., (2000). Handbook of Nanostructured Materials and Nanotechnology (5 th ed-n), Academic Press (USA). 4. Council of the European Union (2012). Competitiveness (Internal Market


The present scientific paper is the fourth part and continuation of the in-depth scientific study of the developed system of engineering economic indicators, where the authors obtain results from the scientific research presented in a series of works on the development of the nanotechnologies and advanced materials industry in science and entrepreneurship in Latvia. Part Four determines the essential legal indicators of the development of nano-field at the macro, micro, and meso development levels of the economic environment in Latvia. The paper provides the interaction of new identified indicators of nano-field in terms of further scientific and practical activities. Latvia is analysed in comparison with other countries in the world.

., Staube, T., Ciemleja, G., Zeltins, N., & Ekmanis, J. (2016). The development of nanotechnologies and advanced materials industry in science and entrepreneurship: Socioeconomic and technical indicators. A case study of Latvia (Part One). Latvian Journal of Physics and Technical Sciences (53), 4, 3–13, DOI: 10.1515/lpts-2016-0023. 10. Employment (main characteristics and rates) – Annual averages. (n.d.). Eurostat. Retrieved 19 December 2015, from 11. Economically active population by education level and

] With such a short median survival, it is essential that we uncover novel techniques to treat patients with GBM. Current research shows that the genetic profile of GBM is leading to resistance to TMZ and radiation, but a major battle in the treatment of GBM is drug delivery across the blood–brain barrier (BBB). There is hope for patients with GBM because nanotechnology has been able to demonstrate the ability to cross the BBB. A number of nanomaterials, including liposomes, nanoemulsion, polymeric micelles, and iron oxide nanoparticles (IONP) have been investigated as

.O., 2014, Nanotechnology and its applicaton in dentstry. Annals of Medical and Health Sciences Research, 4 : 171-177. Abubakar, A.S., Salisu, I.B., Chahal, S., Sahni, S., Pudake, R.N., 2014, Biosynthesis and characterization of silver nanoparticles using black carrot root extract. International Journal of Current Research and Review, 6 : 5-8. Abul-Ezz, A., 2004, Development of scientific concepts and skills and teaching methods . Oman: Dar Thought for Printing, Publishing and Distribution. Adebayo-Tayo, B.C., Inem, S.A., Olaniyi, O.A., 2019, Rapid synthesis and