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surgery. Br J Anaesth. 2000; 85:109-117. Fendrich Z. Metamizol - a New Effective Analgesic with a Long History: A Survey of Pharmacology and Clinical Applications. Čas. Lék. Čes. 2000; 139(14):440-444. Graff J, Arabmotlagh M, Cheung R, Geisslinger G, Harder S. Effects of Parecoxib and Dipyrone on Platelet Aggregation in Patients Undergoing Meniscectomy: A Double- Blind, Randomized, Parallel-Group Study. Clin Ther. 2007; 29:438-447. Hinz B. et al. Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an

microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer. Int. J. Pharm. , 188(2), 181, 1999. 15. Martínez-Martín P. et al.: Efficacy and safety of metamizol vs. acetylsalicylic acid in patients with moderate episodic tension-type headache: a randomized, double-blind, placebo- and active-controlled, multicentre study. Cephalalgia , 21(5), 604, 2001. 16. Murtada A.O., Abdelkarim M.A., Huyam A.M.: The effect of sodium starch glycolate concentration on physical effectiveness of chlorpheniramine tablets. Indian J. Pharm. Educ

. Grossman R, Ram Z, Presel A, Yusim Y, Zaslansky R, Berkenstadt H. Control of postoperative pain after awake craniotomy with local intradermal analgesia and metamizol. Isr Med Assoc J. 2007; 9:360-2. 14. Nguyen A, Girard F, Boudreault D, Fugere F, Ruel M, Moumdjian R, et al. Scalp nerve blocks decrease the severity of pain after craniotomy. Anesth Analg. 2001; 93: 1272-6. 15. Bala I, Gupta B, Bhardwaj N, Effects of scalp block on postoperative pain relief in craniotomy patients. Anesth Intensive Care. 2006; 34:224-7. 16. Ayoub C, Girard F, Boudreault D, Chouinard P, Ruel