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Effect of xanthoxylin on melanin content and melanogenic protein expression in B16F10 melanoma

Elevating a cAMP Level in B16 Melanoma Cells. J Invest Dermatol. 2005; 124:405-11. 5. Brenner M, Hearing VJ. Modifying skin pigmentationapproaches through intrinsic biochemistry and exogenous agents. Drug Discovery Today: Disease Mechanisms. 2008; 5:189-99. 6. Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 2004; 84:1155-228. 7. Sturm RA, Teasdale RD, Box NF. Human pigmentation genes: identification, structure and consequences of polymorphic

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Effect of UV irradiation on free radicals in synthetic melanin and melanin biopolymer from Sepia officinalis – EPR examination

References 1. Sarna, T. (1981). Study of the structure and properties of the melanin active centers. Zagadnienia Biofizyki Współczesnej , 6, 201–219 (in Polish). 2. Pasenkiewicz-Gierula, M. (1990). Study of the structure and dynamics of paramagnetic molecular systems with spin of s=1/2 by electron paramagnetic resonance (EPR) method. D. Sc. Thesis, Jagiellonian University, Kraków (in Polish). 3. Plonka, P., Michalczyk, D., Popik, M., Handjiski, B., & Paus, R. (2008). Electron paramagnetic resonance (EPR) spectroscopy for investigating murine

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Continuous microwave saturation of EPR spectra of melanin complexes at different temperatures

References Biggs P. J, Ling C. C. Electron as the cause of the observe d max shift with field size in high energy beams. Med Phys. 1979; 6: 291-295. Beberok A, Buszman E, Zdybel M, Pilawa B, Wrześniok D. EPR examination of free radical properties of DOPA-melanin complexes with ciprofloxacin, lomefloxacin, norfloxacin and sparfloxacin. Chem Phys Letters. 2010;497:115. Bilińska B, Pilawa B, Zawada Z, Wylpgała E, Wilczok T, Dontsov AE, Sakina MA, Ostrovsky MA, Ilyasova VB. Electron

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The acid-catalyzed interaction of melanin with nitrite ions. An EPR investigation

References 1. Reszka, K., & Jimbow, K. (1993). Electron donor and acceptor properties of melanin pigments in the skin. In J. Fuchs & L. Packer (Eds.), Oxidative stress in dermatology (pp. 287–320). New York: Marcel Dekker, Inc. 2. Sealy, R. C. (1984). Free radicals in melanin formation, structure and reactions. In D. Armstrong, R. S. Sohal, R. G. C. Cutler & T. R. Slater (Eds.), Free radicals in molecular biology, aging and disease (pp. 67–76). New York: Raven Press. 3. Prota, G. (1992). The role of peroxidase in melanogenesis revisited

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Antioxidant, antibacterial properties and the light barrier assessment of raw and purified melanins isolated from Citrullus lanatus (watermelon) seeds

, Mwakikunga B, Dhlamini SM, Park E et al. Morphological and chemical composition characterization of commercial sepia melanin. AJN 2015; 3(1):22-27. doi: 15. Li H, Li J, Zhao Z. Characterisation of melanin isolated from apricot ( Armeniaca sibirica ) and its effect on hydrazine-induced rat hepatic injury. Sci Asia 2016; 42:382-391. doi: 16. Wang H, Pan Y, Tang X, Huang Z. Isolation and characterization of melanin from Osmanthus fragrans’ seeds. LWT – Food Sci Technol

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Tlr2, Tjp1 genes expression during wound healing dynamics – with melanin treatment

Biochem., 162, 156, 1987. 4. Cui Y. et al.: Chrysanthemum morifolium extract attenuates high-fat milk-induced fatty liver through peroxisome proliferator-activated receptor alpha-mediated mechanism in mice. Nutr Res., 34 ,268, 2014. 5. De Benedetto A. et al.: Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol, 127, 773, 2011. 6. Dranitsina A.S. et al.: TGFB 1, PTGS 2 Genes Expression during Dynamics of Wound Healing and with the Treatment of Melanin. Research J Pharm Biol Chem Sci, 8, 2014

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Sexual selection, range size and population size

158: 136-145. Moreno, J. & Møller, A. P. 2006. Melanin deposition, oxidative stress and immunity: are melanin ornaments signalling antioxidant and immune capacity? - Acta Zoologica Sinica 52: 202-208. Nakagawa, S. 2004. A farewell to Bonferroni: the problems of low statistical power and publication bias. - Behavioral Ecology 15: 1044-1045. Olson, V. & Owens, I. P. F. 2005. Interspecific variation in the use of carotenoid-based coloration in birds: diet, life history and phylogeny. - Journal of Evolutionary Biology 18

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Variation of Human Hairiness: A Possible Adaptation to Solar Radiation and Melanin

References Ali I, Wojnarowska F. 2011. Physiological changes in scalp, facial and body hair after the menopause: a cross-sectional population-based study of subjective changes. Brit J Dermatol 164:508-13. Becker WS. 1927. Melanin Pigmentation Systematic Study of the Pigment of the Human Skin and Upper Mucous Membranes, with Special Consideration of Pigmented Dendritic Cells. Arch Derm Syphilol 16:259-90. Candille SI, Absher DM, Beleza S, Bauchet M, McEvoy B, Garrison NA, Li JZ, Myers RM, Barsh GS, Tang H, Shriver MD. 2012. Genome-Wide Association

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Melanogenesis inhibitory activity of Korean Undaria pinnatifida in mouse B16 melanoma cells


A number of seaweed species are used as traditional foods and medicine in different parts of the world, including Asian countries. However, very few data on the anti-melanogenic effect of seaweed have been published. Undaria pinnatifida (Dolmiyeok), a brown alga, is a traditional food in Jeju Island, the southern regions of the Korea peninsula. In this study, ethylacetate extracts of U. pinnatifida (UPE) were examined for their anti-melanogenic potentials. Our results supports the finding that UPE down-regulated melanin content in a dose-dependent pattern. To clarify the target of UPE action in melanogenesis, we performed Western blotting for tyrosinase and microphthalmia-associated transcription factor (MITF), which are key melanogenic enzymes. UPE inhibited tyrosinase and MITF expressions in a dose-dependent manner. These results indicate that treatment with UPE significantly inhibits the melanogenesis in B16 cells, and may be effective in the whitening agent for the skin

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Effects of psychological stress on skin and hair pigmentation in Polish adolescents

cutaneous response to stress. Physiol Rev 80:979-1020. Slominski A, Wortsman J, Pisarchik A, Zbytek B, Linton EA, Mazurkiewicz JE, Wei ET. 2001. Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J 15(10):1678-93. Slominski A, Tobin DJ, Shibahara S, Wortsman SJ. 2004. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84:1155-228. Slominski A, Plonka PM, Pisarchik A, Smart JL, Tolle V, Wortsman J, Low MJ. 2005a. Preservation of eumelanin hair

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