stimuli is known as mechanotransduction [ 1 ].
Mechanotransduction is of fundamental significance in cell physiology besides the obvious application in facilitating sensing in specialized mechanoreceptors involved in touch, such as Pacinian corpuscles, Meissner’s corpuscles, Merkel’s discs and Ruffini endings found in glabrous skin [ 3 ], and hearing, such as hair cells in the cochlea [ 5 ]. In particular, mechanotransduction is involved in many important cell-regulated processes in tissues such as the growth of bone and muscle [ 6 , 7 ], the development of blood
Viktória Mezencevová, Jozef Torok, Tatiana Czánová and Ján Zajac
Using the effect of mechanical forces affecting cellular response in the treatment of post-traumatic, postoperative, post-imlantation conditions through the application of Endermologie®- mechanotransduction represents a revolutionary solution in tissue-rehabilitation and positive target tissue influencing, with faster regeneration (1). Endermologie® is a noninvasive, painless, natural method of treatments of all connective tissue transformations, muscle and circulation pathologies. The aim of our study is investigation and explanation the mechanism of action by observing the physiological effects of Endermologie® based on human studies. The paper is focused on monitoring of possitive effect tissue regeneration using endermologie as a tools mechanostimulation improvements of systems integridy and health improvement.
Ionuț Ferenț, István Benedek, Alina Corduneanu, András Mester, Theodora Benedek and Imre Benedek
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10. Davies PF, Polacek DC, Handen JS, Helmke BP, DePaola N. A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis. Trends Biotechnol . 1999;17:347-351.
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Ming-Jui Hung, Ming-Yow Hung, Wen-Jin Cherng and Li-Fu Li
of the rat trachea: fate of neutrophils that adhere to venules. J Appl Phyiol. 1990; 69:2131-6.
11. McDonald DM. Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli. Am J Physiol. 1994; 266(1 Pt 1):L61-83.
12. Uhlig S. Ventilation-induced lung injury and mechanotransduction: stretching it too far? Am J Physiol Lung Cell Mol Physiol. 2002; 282:L892-6.
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-actin distribution elicited by low shear stress in vivo. Am J Pathol . 1993;142:1392-1400.
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13. van der Giessen A, Schaap M, Gijsen FJ, et al. 3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis: a feasibility study. Int J Cardiovasc Imaging . 2010;26:781-796.
14. Stone PH, Saito S, Takahashi S, et al. Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of
Ioan Ferenț, András Mester, Monica Chițu, Annabella Benedek, Mihaela Rațiu, Roxana Hodas and Imre Benedek
, Benedek I. Multislice computed tomographic coronary angiography for quantitative assessment of culprit lesions in acute coronary syndromes. Can J Cardiol . 2013;29:364-371.
15. Collet C, Chevalier B, Cequier A, et al. Diagnostic Accuracy of Coronary CT Angiography for the Evaluation of Bioresorbable Vascular Scaffolds. JACC Cardiovasc Imaging . 2018;11:722-732.
16. Chien S. Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol . 2007;292:H1209-H1224.
17. Oncel D, Oncel G, Karaca M. Coronary
Vascular endothelium, the inner lining of the blood vessel wall, constantly responds to hemodynamic forces from blood flow. Thus, mechanical cues and the subsequent mechanotransduction in vascular endothelial cells (ECs) greatly affect vascular physiology and pathophysiology.[ 1 , 2 , 3 ] The molecular mechanisms underlying the flow regulation of endothelial biology have been studied intensively by many labs including our own. In general, the blood flow pattern in the straight part of the arterial tree is less disturbed with high mean shear
Ervin Taso, Mia Rakic, Vladimir Stefanovic, Aleksandra Petković-Curcin, Ivan Stanojevic, Mirjana Djukic, Xavier Struillou, Danilo Vojvodic, Tatjana Banovic and Tatjana Kanjevac
33. Nakamura H, Aoki K, Masuda W, Alles N, Nagano K, Fukushima H, Osawa K, Yasuda H, Nakamura I, Mikuni-Takagaki Y, Ohya K, Maki K, Jimi E. Disruption of NF-κB1 prevents bone loss caused by mechanical unloading. J Bone Miner Res. 2013; 28:1457-67.
34. Liedert A1, Kaspar D, Blakytny R, Claes L, Ignatius A. Signal transduction pathways involved in mechanotransduction in bone cells. Biochem Biophys Res Commun. 2006; 349:1-5.
35. Nozaki K, Kaku M, Yamashita Y, Yamauchi M, Miura H. Effect of cyclic mechanical loading on osteoclast recruitment in
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 Acharya R.C., van der Zee S.E.A.T.M. and Leijense A. (2004): Porosity-permeability properties generated with a new 2-parameter 3D hydraulic pore-network model for consolidated and unconsolidated porous media. - Adv. Water Res., vol.27, pp.707-723.
 Chen C.S. (2008): Mechanotransduction - a field pulling together