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Carcinogenesis induced by low-dose radiation

be repaired which makes it more favorable for cells than high-dose rate radiation. 14 This review contains a description of biological consequences of low-dose radiation and possible induction of cancer ( Figure 1 ). Figure 1 Diagram illustrating targeted and non-targeted effect induced by radiation (all described in the main text). DNA damage Damage to DNA is one of the most important factors in radiation induced cancer transformation. Even though ionizing radiation induces one DSB per 20 SSBs, research indicates that DSBs are much more

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Cancer induced by exposure to ionizing radiations in medical personnel

Abstract

Ionizing radiation are classified as Class I carcinogens. The exposure to this factor increases the risk of developing cancer, and researchers aim to establish the relationship between the exposure and the risk levels, as well as guidelines which would limit exposure to it. The risks were assessed through studies related to the atomic bomb survivors, to the populations exposed to radiation for the purpose of diagnosis or therapy and to the professionally exposed populations – radiologists, radiotherapists, workers in uranium mines, operatives in the nuclear industry. The population of Japanese survivors of the atomic bombs is the largest population exposed and studied with an extremely wide age range (from the irradiation in utero to old people). This population, made up of 93.000 people, represents a major source of information used to determine the potential risk of low dose radiation exposure. Health professionals working with ionizing radiation have been studied ever since the 1890’s. After the implementation of a radiation protection system, the doses received decreased only to increase again with the technical development and its use in a wide variety of specialties. Two recent studies on large cohorts and during long periods of time brought information about the cancer risk due to occupational exposure to ionizing radiation and shed light on the need to monitor exposed staff and re-evaluate radiological safety standards. This review is focused on recent literature concerning the radiation exposure of medical professionals.

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Biological Effects of Echinacea Purpurea on Human Blood Cells

;28:625--31. Lanza V, Pretazzoli V, Olivieri G, Pasccarella G, Panconesi A, Negri R. Transcriptional response of human umbilical vein endothelial cells to low doses of ionizing radiation. J Radiat Res 2005;46:265--76. Mohrenweiser HW, Jones IM, Wilson D. III DNA repair gene variants: Understanding mechanisms of cellular response and estimating individual health risk from low-dose radiation. In: DOE Low Dose Radiation Research Program, Workshop I; 10-12 Nov 1999. Washington, D.C. Abstracts. [displayed 16 March 2009]. Available at http

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Complexity of free radical Metabolism in human Erythrocytes

Psychiatry 1980; 137: 383-6. Žunić Z, Blagojević D, Spasić M, Đuić J, Nikolić A, Marković S, Saičić ZS. Low dose radiation effects on the activity of antioxidative defence in the blood of healthy examinees Health effects of low dose radiation. Challenges of the 21st century, BNES, London 1997, 214-1.

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Machine learning techniques combined with dose profiles indicate radiation response biomarkers

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A Monte Carlo study on dose enhancement and photon contamination production by various nanoparticles in electron mode of a medical linac

novel x-ray enhancer for low-dose radiation therapy. J. Phys. Chem. B. , 118 (23), 6159–6166. DOI: 10.1021/jp5026224. 22. Roeske, J. C., Nunez, L., & Hoggarth, M. (2007). Characterization of the theoretical radiation dose enhancement from nanoparticles. Technol. Cancer Res. Treat ., 6 (5), 395–401. 23. Kim, J. K., Seo, S. J., & Kim, K. H. (2010). Therapeutic application of metallic nanoparticles combined with particle-induced x-ray emission effect. Nanotechnology , 21 (42), 425102. DOI: 10.1088/0957-4484/21/42/425102. 24. Bakhshabadi, M

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Interpretation of Gamma Index for Quality Assurance of Simultaneously Integrated Boost (SIB) IMRT Plans for Head and Neck Carcinoma

planning. Med Phys. 1998;25(10):1773-1829. [27] Jang SY, Liu HH, Mohan R. Underestimation of low-dose radiation in treatment planning of intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2008;71(5):1537-1546. [28] Deng J, Pawlicki T, Chen Y, et al. The MLC tongue-and-groove effect on IMRT dose distributions. Phys Med Biol. 2001;46(4):1039-1060 [29] Li JS, Lin T, Chen L, et al. Uncertainties in IMRT dosimetry. Med Phys. 2010;37(6):2491-2500. [30] Das IJ, Ding GX, Ahnesjö A. Small fields: nonequilibrium radiation dosimetry. Med Phys

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Estimation of cell response in fractionation radiotherapy using different methods derived from linear quadratic model

of cells to ionizing radiation. J Radiobiol 2014; 1: 3-8. 27. Shanei A, Baradaran-Ghahfarokhi M. Evaluation of testicular dose and associated risk from common pelvis radiation therapy in Iran. Physica Medica 2014; 30: 867-70. 28. Cherubini R, De Nadal V, Gerardi S, Guryev D. Status report of a systematic investigation on low dose ionizing radiation effects in mammalian cells. Nuoro Cimento C 2008; 1: 57-67. 29. Smith LG, Miller RC, Richard SM, Brenner DJ, Hall EJ, Phil D. Investigation of hypersensitivity to fractionated low dose

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Absence of mutations in the human interferon alpha-2b gene in workers chronically exposed to ionising radiation

ionizing radiation. Cancer Lett 2015;356:105–13. doi: 10.1016/j.canlet.2013.09.015 4. Voos P, Fuck S, Weipert F, Babel L, Tandl D, Meckel T, Hehlgans S, Fournier C, Moroni A, Rödel F, Thiel G. Ionizing radiation induces morphological changes and immunological modulation of Jurkat cells. Front Immunol 2018;9:922. doi: 10.3389/fimmu.2018.00922 5. Shahid S, Mahmood N, Nawaz Chaundhry M, Sheikh S, Ahmad N. Mutations of the human interferon alpha-2b (hIFN-α2b) gene in occupationally protracted low dose radiation exposed personnel. Cytokine 2015;73:181–9. doi: 10

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The concept of radiation-enhanced stem cell differentiation

-608. 54. Armesilla-Diaz A, Bragado P, Del Valle I, Cuevas E, Lazaro I, Martin C, et al. p53 regulates the self-renewal and differentiation of neural precursors. Neuroscience 2009; 158: 1378-89. 55. Monje ML, Mizumatsu S, Fike JR, Palmer TD. Irradiation induces neural precursor-cell dysfunction. Nat Med 2002; 8: 955-62. 56. Wei L-C, Ding Y-X, Liu Y-H, Duan L, Bai Y, Shi M, et al. Low-dose radiation stimulates Wnt/β-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo. Curr Alzheimer Res

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