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Renin–angiotensin–aldosterone system in insulin resistance and metabolic syndrome

-II signaling reduces food intake by suppressing the hypothalamic expression of neuropeptide Y and orexins via AMPK dephosphorylation [ 48 ] . Ras, Estrogen, and Lipoxin A4 In this context, it is noteworthy that ovariectomized (OVX) female rats treated with estradiol benzoate (EB) had a 30–40% reduction in the levels of AT-I receptor mRNA in pituitary and HTS (hypothalamic-thalamic-septa) tissue samples as compared to OVX, control animals. In the pituitary, the mRNA levels for angiotensinogen (AGT) were increased by 45% following estrogen administration. In addition

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Is aortic aneurysm preventable?

presence of EPA and DHA in the cell membrane (because of their supplementation) can enhance the formation of anti-inflammatory resolvins, protectins and maresins. Even though AA forms the precursor to the anti-inflammatory lipoxin A4 (LXA4), the presence of angiotensin-II, a pro-inflammatory molecule [ 11 - 13 ] perhaps may drive the generation of pro-inflammatory metabolites from AA instead of anti-inflammatory LXA4. In a previous study, [ 14 ] we showed that PUFAs inhibit the activity of angiotensin converting enzyme (ACE) that is needed for the formation of Ang

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Chemerin rs17173608 Gene Polymorphism is not Associated with Type 2 Diabetes Mellitus: a Cross-sectional Study

counterregulated by lipoxin A4 and resolvin E1. FASEB J 2011;25(5):1697-705. 7. Cash JL, Hart R, Russ A, et al. Synthetic chemerinderived peptides suppress inflammation through ChemR23. J Exp Med 2008;205(4):767-75. 8. Hashemi M, Rezaei H, Eskandari-Nasab E, et al. Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report. Gene 2012;510(2):113-7. 9. De Palma G, Castellano G, Del Prete A, et al. The possible role of ChemR23/Chemrin axis in the recruitment of dendritic cells in lupus nephritis

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Molecular mechanisms for NG-nitro-L-arginine methyl ester action against cerebral ischemia–reperfusion injury-induced blood–brain barrier dysfunction

early stage of cerebral ischemia and reperfusion. Neuroscience. 2012; 212:180-9. 35. Ryang Y-M, Dang J, Kipp M, Petersen K-U, Fahlenkamp AV, Gempt J, et al. Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats. BMC Neurosci. 2011; 12:113. 36. Wu Y, Wang YP, Guo P, Ye XH, Wang J, Yuan SY, et al. A lipoxin A4 analog ameliorates blood-brain barrier dysfunction and reduces MMP-9 expression in a rat model of focal cerebral ischemia-reperfusion injury. J Mol Neurosci. 2012; 46: 483

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Low-grade chronic inflammation perpetuated by modern diet as a promoter of obesity and osteoporosis

liver microsomes. Lipids 1975;10:315-7. PMID: 1134219 15. Nigam S, Fiore S, Luscinskas FW, Serhan CN. Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: Dissociation between lipid remodeling and adhesion. J Cell Physiol 1990;143:512-23. PMID:2162850 16. Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S, Arita M, Serhan CN. Resolvin E2: Identification and anti-inflammatory actions: Pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem

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Genetic variability in the loci of FABP4, PPARγ and SCD genes of sheep breeds raised for different purposes

). Synthesis of lipoxin A 4 by 5-lipoxygenase mediates pparγ-dependent, neuroprotective effects of rosiglitazone in experimental stroke. J. Neurosci., 29, 3875–3884. Tontonoz P., Hu E., Graves R. A., Budavari A. I. & Spiegelman B. M. (1994). mPPARgamma2: Tissue-specific regulator of an adipocyte enhancer. Gene. Dev., 8, 1224–1234. Wei Y., Wang D., Gentile C. L. & Pagliassotti M. J. (2009). Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells. Mol. Cell. Biochem., 331, 31

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Pharmacological therapies for acute respiratory distress syndrome

;119(11):3450–61. 18. Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Oct;124(17):2625–34.. 19. Melot C, Lejeune P, Naeije R, Leeman M, Hallemans R. Effects of increased pulmonary vascular tone on gas exchange in canine oleic acid pulmonary edema. J Appl Physiol. 2017;65(2):662–8. 20. Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, et al. Effect of Aspirin on Development of ARDS in At-Risk Patients

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Seeking Optimal Nutrition for Healthy Body Mass Reduction Among Former Athletes

40°C/min to 160°C (0 min), then increased at the rate of 30°C/min to 190°C (0.5 min) and finally increased at the rate of 30°C/min to 230°C for 2.6 min, where it was maintained for 4.9 min. The total analysis lasted approximately 8 min and the gas flow rate was 0.8 ml/min with hydrogen as the carrier gas. Fatty acids were identified by comparing their retention times with those of commercially available standards. Isolation and analyses of fatty acid derivatives 5(S),6(R)-Lipoxin A 4 , 5(S),6(R), 15(R)- Lipoxin A 4 , 5(S)-HETE, 5(S)-oxoETE, 12(S)-HETE, 15(S

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