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References 1. Jianping Ye, Mechanisms of insulin resistance in obesity, Front Med. 2013 Mar; 7(1): 14–24. 2. John R. Petrie, Shinichiro Ueda,, Endothelial Nitric Oxide Production and Insulin Sensitivity A Physiological Link With Implications for Pathogenesis of Cardiovascular Disease, Circulation. 1996;93:1331-1333 3. Jonathan D. Schofield, Yifen Liu, Diabetes Dyslipidemia, Diabetes Ther. 2016 Jun; 7(2): 203–219. 4. Mulnier HE, Seaman HE, Raleigh VS, Soedamah-Muthu SS, Colhoun HM, Lawrenson RA, de Vries CS, Risk of myocardial infarction in men and

References 1. Ausk KJ, Boyko EJ, Ioannou GN. Insulin resistance predicts mortality in nondiabetic individuals in the U.S. Diabetes Care. 2010;33:1179e85 2. Facchini FS, Hua N, Abbasi F, Reaven GM. Insulin resistance as a predictor of age-related diseases. J Clin Endocrinol Metab. 2001;86:3574-8. 3. McLaughlin TL, Reaven GM. Beyond type 2 diabetes: the need for a clinically useful way to identify insulin resistance. Am J Med. 2003;114:501e2 4. Raynaud E, Perez-Martin A, Brun JF, Benhaddad AA, Mercier J - Revised concept for the estimation of insulin sensitivity

R eferences 1. Ballani P, Tran MT, Navar MD, Davidson MB. Clinical experience with U-500 regular insulin in obese, markedly insulin resistant Type-2 diabetic patients. Diabetes Care. 29: 2504-2505, 2006. 2. Mantzoros CS, Flier JS. Insulin resistance: the clinical spectrum. Adv Endocrinol Metab 6: 193–232, 1995. 3. Oo YH, Karam JG, Resta CA. Extreme insulin resistance in a patient with diabetes ketoacidosis and acute myocardial infarction. Case Rep Endocrinol 2013:520904, 2013. 4. Ovalle F. Clinical approach to the patient with diabetes mellitus and very

. International Journal of Qualitative Studies on Health and Well-being. 2015; 10: 29026. 5. BALSAN GA., VIEIRA JLDC., OLIVEIRA AMD., PORTAL VL. Relationship between adiponectin, obesity and insulin resistance . Rev Assoc Bras. 2015;61(1):72-80. 6. RODRIGUES TC., CANANI LH., GROSS JL. Metabolic syndrome, insulin resistance and cardiovascular disease in type-1 diabetes mellitus . Arq Bras Cardiol. 2010;94(1):125-130. 7. MATTHEWS DR., HOSKER JP., RUDENSKI AS., NAYLOR BA., TREACHER DF., TURNER RC. Homeostatis model assessment: insulin resistance and beta-cell function from

.G., ZIMMET P., SHAW J., Metabolic syndrome – a new world wide definition. A concencus state from the International Diabetes Federation , Diabet. Med., 2006, 23:469–480. 5. KARPE F., DICKMANN J.R., FRAYN K.N., Fatty acids, obesity, and insulin resistance: time for reevaluation , Diabetes, 2011; 60:2441–2447. 6. MCARDLE M.A., FINUCANE O.M., CONNAUGHTON R.M., MCMORROW A.M., ROCHE H.M., Mechanisms of obesity-induced inflamation and insulin resistance: insights into emerging role of nutritional strategies , Front. Endocrinol., 2013, 4:52. 7. TCHERNOF A., DESPRES J

liver disease is characterized by elevated levels of CCL2. Journal of Hepatology 2006; 44(6): 1167–74. 10. Yang R-Z, Lee M-J, Hu H, Pray J, Wu H-B, Hansen BC, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. American Journal of Physiology-Endocrinology and Metabolism 2006; 290(6): E1253–E61. 11. Heiker JT. Vaspin (serpinA12) in obesity, insulin resistance, and inflammation. Journal of Peptide Science 2014; 20(5): 299–306. 12. Aktas B, Yilmaz Y, Eren F, Yonal O, Kurt R, Alahdab YO

References 1. Deedwania P. Hypertension, dyslipidemia, and insulin resistance in patients with diabetes mellitus or the cardiometabolic syndrome: benefits of vasodilating β- blockers. J Clin Hypertens (Greenwich) 13: 52-59, 2011. 2. Henry N. Ginsberg. Insulin resistance and cardiovascular disease. J Clin Invest 106: 453-458, 2000. 3. Steinberger J, Daniels SR, American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) et al. Obesity, insulin resistance, diabetes, and cardiovascular

REFERENCES 1. De Koster JD, Opsomer G: Insulin resistance in dairy cows. Vet Clin North Am Food Anim Pract 2013, 29(2):299-322. 2. Sundrum A: Metabolic Disorders in the Transition Period Indicate that the Dairy Cows’ Ability to Adapt is Overstressed. Animals 2015, 5: 978-1020. 3. Hayirli A: The role of exogenous insulin in the complex of hepatic lipidosis and ketosis associated with insulin resistance phenomenon in postpartum dairy cattle. Vet. Res. Commun. 2006, 30:749–774. 4. Singh B, Saxena A: Surrogate markers of insulin resistance: A review. World J Diabetes

technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23(1): 57-63, 2000. 6. Katsuki A, Sumido Y, Gabazza E et al. Homeostasis Model Assessment Is a Reliable Indicator of Insulin Resistance During Follow-up of Patients With Type 2 Diabetes. Diabetes Care 24(2): 362-365, 2001. 7. Gast KB, Tjeerdema N, Stijnen T, Smit JW, Dekkers OM. Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis. PLoS One 7(12): e52036, 2012. 8

References 1. Ionescu - Tîrgovişte C, Guja C, Brădescu O. Insulinorezistența obișnuită și cea severă. In: Tratat de diabet Paulescu. Ionescu - Tirgoviste C (ed). Publisher Romanian Academy Publishing House, Bucharest, pp 677-684, 2004. 2. Olefsky JM, Kruszynska YT. Insulin resistance. In Ellenberg and Rifkin’s Diabetes Mellitus 6th edition. Porte DJ, Sherwin RS, Baron A (ed). Eds. McGraw-Hill, New York, pp 367-400, 2003. 3. Rosenbloom AL. Obesity, insulin resistance, β- cell autoimmunity and the changing clinical epidemiology of childhood diabetes. Diabetes Care