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A current review of dose-escalated radiotherapy in locally advanced non-small cell lung cancer

methods PubMed and EMBASE were searched using the following keywords: locally advanced non-small cell lung cancer, unresectable non-small cell lung cancer, radiotherapy, radiation therapy, dose escalation, hyperfractionation, hypofractionation, adaptive radiotherapy, proton radiotherapy, carbon ion radiotherapy. Clinical studies, clinical trials, meta-analysis, reviews and references from the articles were selected and further classified into altered radiotherapy delivery regimens, personalized radiotherapy regimen and new techniques: proton and heavy ion radiotherapy

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A new instrument for predicting survival of patients with cerebral metastases from breast cancer developed in a homogeneously treated cohort

optimal WBRT regimen, estimation of the patient’s OS prognosis appears crucial. Several instruments were developed in cohorts of patients receiving WBRT including the recursive partitioning analysis (RPA) classification, the graded prognostic assessment (GPA) classification and the WBRT-30. 12 , 14 ,, 15 Patients used to develop the RPA and GPA classifications had received various treatments such as different WBRT-regimens including hyperfractionation, WBRT plus misonidazole and WBRT plus chemotherapy. 14 , 15 , For the development of the GPA classification

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Radiotherapy of glioblastoma 15 years after the landmark Stupp’s trial: more controversies than standards?

associated with further survival improvement. 24 The later attempts to improve outcomes by an increase of RT dose included combination of 60 Gy WBRT and increased targeted dosage by IMRT 25 , brachytherapy 26 , or stereotactic radiosurgery (RTOG 9305). 27 Increasing focused radiation dose by hyperfractionation was tested as well. 28 Doses above 60 Gy have not proven to be beneficial even in the TMZ era. 29 One might conclude that the question of the correct total dose in adjuvant RT is a closed chapter and further studies in this field are not judged. On the other

Open access