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Comparison of cerebrovascular reactivity tests: a pilot human study

since the name 'REG' was initially used [ 3 , 26 ], and the promise of REG has been demonstrated [ 4 , 27 ]. Conclusion Here we have presented initial results of pilot human study comparing CBF challenges in order to find an optimal CBF AR test for potential use on the battlefield, during transport of wounded warriors and for use in neurosurgery intensive care units (military and civilian). Some discrepancies among REG, NIRS, TCD and LDF methodologies were observed during these tests. Our future validation studies will include enhanced computational methods

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The Influence of Study Specialization on the Moral Reasoning in University Students

Abstract

Significant importance has been attributed to moral judgment with regard to the moral and complex personal development of an individual. The study is focused on the moral thinking of university students, being interested in whether or not and to what extent does the university students´ specialization of study affect their moral judgment. A total of 180 students participated in the survey, half of them with technical specialization and the other half with humane disciplines. The Moral Judgment Test was used as a research tool for measuring their moral reasoning. The results showed a significant relation between the students´ moral reasoning and study specialization. Students with humane study specialization showed a much higher level of moral reasoning, referring to an input in the discussion on the method of developing university students´ moral competences.

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Mesenchymal Stem Cell Therapy for rheumatic diseases

application of MSCT in patients with SLE, compared with animal studies, showed more rewarding results. In an initial small-scale human study in Carrion et al . ( 8 ), autologous bone-marrow-derived MSCs were administered intravenously in two patients with SLE. It showed no clinical improvement in the disease activity, and renal flare was even diagnosed in one patient 4 months after MSCT. However, as the follow-up period was 14 months only, conclusion of inefficacy could not be drawn. Subsequent studies showed more promising results in MSCT. Sun et al . ( 9 ) demonstrated

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The association between enteroviruses and type 1 diabetes

viruses: the enterovirus link to type 1 diabetes: critical review of human studies. Clin Exp Immunol 168: 12-23, 2012. 6. Gale EAM. Viruses and type 1 diabetes: ignorance acquires a better vocabulary. Clin Exp Immunol 168: 1-4, 2012. 7. Vehik K, Dabelea D . The changing epidemiology of type 1 diabetes: why is it going through the roof? Diabetes Metab Res Rev 27: 3-13, 2011. 8. Kondrashova A, Reunanen A, Romanov A et al . A six-fold gradient in the incidence of type 1 diabetes at the eastern border of Finland. Ann

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The effects of modified ultrafiltration on clinical outcomes of adult and pediatric cardiac surgery

bypass, extracorporeal circulation, pediatric and adult cardiac surgery, complications, and morbidities. The identified articles were subsequently screened for their relevancy. The searches were limited to English language articles and human studies. The relevant studies were further assessed for their level of evidence and quality using several criteria including type of research studies, randomization, blinding, sample size, sample selection, intention to treat analysis, inclusion and exclusion criteria, and methods. Results Our literature search identified

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Studies in Rheoencephalography (REG)

was calculated in Matlab (Natick, MA) for determination of lower limit of CBF AR [ 61 , 62 , 63 ]. Results: This study demonstrated that with surface electrodes REG can be used to detect lower limit of CBF AR. Human studies CO 2 inhalation CO 2 inhalation caused increase in cerebral blood volume, measured by radioiodinated human serum albumin (RIHSA) and REG pulse amplitude [ 32 ]. Evaluation of commercially available electrode materials Bioimpedance can be used for peripheral pulse detection as a non-invasive method for continuous vital sign

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Endermologie New Aproach in the Medicine Treatment

Abstract

Using the effect of mechanical forces affecting cellular response in the treatment of post-traumatic, postoperative, post-imlantation conditions through the application of Endermologie®- mechanotransduction represents a revolutionary solution in tissue-rehabilitation and positive target tissue influencing, with faster regeneration (1). Endermologie® is a noninvasive, painless, natural method of treatments of all connective tissue transformations, muscle and circulation pathologies. The aim of our study is investigation and explanation the mechanism of action by observing the physiological effects of Endermologie® based on human studies. The paper is focused on monitoring of possitive effect tissue regeneration using endermologie as a tools mechanostimulation improvements of systems integridy and health improvement.

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Infective Endocarditis in Children — New Approach in Antimicrobial Prophylaxis

Abstract

Infective endocarditis (IE) is an infection of the endocardium and/or heart valves with the formation of a thrombus and secondary damage of the involved tissue, with significant mortality and severe complications. The prevention of bacterial endocarditis is of great controversy. Antimicrobial prophylaxis is usable in the prevention of endocarditis by killing bacteria before or after their extension to the damaged endocardium. No human studies offer strong evidence to support the efficacy of antibiotic prophylaxis so far, thus it could be potentially dangerous. Therefore, the European Society of Cardiology (ESC) may need to reconsider and update the previous guidelines with the proposal of reducing the prophylactic approach of IE. The 2015 Task Force recommends prophylaxis for highest risk patients undergoing highest risk procedures, focused on prevention rather than prophylaxis of IE, especially in nosocomial endocarditis.

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Integrative Approaches of Native and Foreign Scholars to Pedology in the Context of Views of the Third Millennium

Abstract

Problems of appearing and functioning of human study science, i.e. pedology, have been studied in the paper. Theoretical analysis of integrative approaches of native and foreign scholars to pedology in the context of views of the third millennium has been performed. Useful and positive achievements of this science as well as wrong ones determined by specific features of time and socio-political conditions, views on children upbringing have been singled out. It has been indicated that at the beginning of the 21st century authoritarian, lacking humanism, scientistic-progressivistic educational paradigm is becoming history. At the same time child-centered, personal-developmental pedagogy is being increasingly included in the teaching practice. In addition, we can clearly trace contours of humanitarian-existential approaches to upbringing problems, which is why we should understand that there is no average child and that except heredity and environment much in the development of a small person depends on upbringing efforts of parents, pedagogues, state and society. Children should not adapt to the conditions since educational-upbringing system, curricula and methods of teaching must be adapted to a child, his/her capabilities, interests and specific features. A child’s interests should be in the basis of the upbringing system. Any system of a child’s upbringing, no matter how progressive and innovative it may be, will not fulfill its mission if it is not based on deep scientific pedology. Rather perspective we consider theoretical analysis of the development of the ideas on integral study of a child in Ukrainian pedology.

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Fibroblast Growth Factor-23: A Novel Biomarker for Cardiovascular Disease in Chronic Kidney Disease Patients

Abstract

Fibroblast Growth Factor (FGF)-23 increase is considered one of the earliest biochemical abnormalities in chronic kidney disease-mineral bone disorder (CKD–MBD). Furthermore, accumulating data have provided evidence of a link between increased FGF-23 levels and cardiovascular morbidity and mortality in CKD patients as well as in several other populations including cardiology patients and general population. The cellular and molecular mechanisms underlying the deleterious effect of FGF-23 on the cardiovascular system are not yet completely defined and are the focus of intense research. However, animal and human studies have demonstrated important actions of FGF-23 in the heart and vessels through which could promote the development of cardiovascular complications in uremia. Moreover, significant interactions have been reported between FGF-23 and other well recognized cardiovascular risk factors such as renin-angiotensin system and inflammation which could account, at least in part, for the observed associations between FGF-23 and adverse clinical outcomes. Further studies are needed to clarify the mechanisms responsible for the pleiotropic actions of FGF-23 and moreover to identify whether it is a modifiable risk factor and a potential target of therapeutic interventions which could probably help to reduce the unacceptably high cardiovascular morbidity and mortality of CKD patients.

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