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UV-crosslinkable warm-melt pressure-sensitive adhesives based on acrylics

UV-crosslinkable warm-melt pressure-sensitive adhesives based on acrylics

The target of this article is to show the preparation of new generation of UV-crosslinkable warm-melt acrylic pressure-sensitive adhesives (PSAs) and the experimental test of their adhesive properties in comparison with typical conventional hot-melts adhesives. New generation of UV-crosslinkable acrylic warm-melts PSAs containing unsaturated photoinitiator, incorporated during polymerization process into polymer chain, and photoreactive diluents added to PSA systems after polymerization allows producing of wide range of self-adhesive materials, such as labels, mounting tapes, masking and splicing tapes, and sign and marking films.

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Synthesis of photoreactive solvent-free acrylic pressure-sensitive adhesives in the recovered system

Synthesis of photoreactive solvent-free acrylic pressure-sensitive adhesives in the recovered system

The present paper discloses a novel photoreactive solvent-free acrylic pressure-sensitive adhesive (PSA) systems, especially suitable for the so much adhesive film applications as the double-sided, single-sided or carrier-free technical tapes, self-adhesive labels, protective films, marking and sign films and wide range of medical products. The novel photoreactive solvent-free pressure-sensitive adhesives contain no volatile organic compounds (residue monomers or organic solvent) and comply with the environment and legislation. The synthesis of this new type of acrylic PSA is conducted in common practice by solvent polymerisation. After the organic solvent are removed, there remains a non-volatile, solvent-free highly viscous material, which can be processed on a hot-melt coating machine at the temperatures of about 100 to 140°C.

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A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

Abstract

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.

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A study of in situ fluid bed melt granulation using response surface methodology / Uporaba metodologije odgovornih površin za študij in situ granulacije s talinami v zvrtinčenih plasteh

Dosage Forms , in Encyclopedia of Pharmaceutical Technology (Ed. J. Swarbrick), 3rd ed., Taylor & Francis Group, New York 2006, pp. 2257-2261; DOI: 10.1081/E-EPT-120018221. 4. T. Abberger, Influence of binder properties, method of addition, powder type and operating conditions on fluid-bed melt granulation and resulting tablet properties, Pharmazie 56 (2001) 949-952; DOI: 10.1016/0006-2952(75)90001-5. 5. M. Kidokoro, Y. Haramiishi, S. Sagasaki and Y. Yamamoto, Application of fluidised hot-melt granulation (FHMG) for the preparation

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Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and paddle methods with simultaneous spectrophotometric determination of active substances

delivery systems. AAPS PharmSciTech. 2009;10(2):597-605. 8. Kraciuk R, Sznitowska M. Effect of different excipients on the physical characteristics of granules and tablets with carbamazepine prepared with polyethylene glycol 6000 by Fluidized Hot-Melt Granulation (FHMG). AAPS PharmSciTech. 2011;12(4):1241-7. 9. Hori S, Kawada T, Kogure S, Yabu S, Mori K, Akimoto M. Comparative release studies on suppositories using the basket, paddle, dialysis tubing and flow-through cell methods I. Acetaminophen in a lipophilic base suppository. Pharm Dev Tech. 2017

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In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets

-coated chronodelivery drug systems, J. Control. Release 157 (2012) 331-353; DOI: 10.1016/j.jconrel.2011.09.065. 4. M. Ghimire, F. J. McInnes, D. G. Watson, A. B. Mullen and H. N. E. Stevens, In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: A pharmacoscintigraphic study in the beagle dog, Eur. J. Pharm. Biopharm. 67 (2007) 515-523. 5. G. P. Andrews, D. S. Jones, O. A. Diak, C. P. McCoy, A. B. Watts and J. W. McGinity, The manufacture and characterisation of hot-melt extruded enteric tablets, Eur. J. Pharm

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Solid dispersion of meloxicam: Factorially designed dosage form for geriatric population

. Obreza, M. Bele and S. Srcic, Physical properties and dissolution behaviour of nifedipine/mannitol solid dispersions prepared by hot melt method, Int. J. Pharm. 291 (2005) 51-58; DOI: 10.1016/j.ijpharm.2004.07.042. M. C. Gohel and L. D. Patel, Improvement of nimesulide dissolution from solid dispersions containing croscarmellose sodium and Aerosil® 200, Acta Pharm. 52 (2002) 227-241.

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Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer

References J. Hamdani, A. J. Moes and K. Amighi, Development and evaluation of prolonged release pellets obtained by the melt pelletization process, Int. J. Pharm. 245 (2002) 167--177; DOI: 10.1016/S0378-5173(02)00348-4. C. R. Young, J. J. Koleng and W. James, Production of spherical pellets by a hot-melt extrusion and spheronization process, Int. J. Pharm. 242 (2002) 87--92; DOI: 10.1016/S0378-5173(02)00152-7. D. Voinovich, M. Moneghini, B. Perissuti, J. Filipovic-Grcic and I

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Box-Behnken experimental design in the development of pectin-compritol ATO 888 compression coated colon targeted drug delivery of mesalamine

. Fell, D. Attwood, H. Sharma and P. Woodhead, Studies on pectin formulations for colonic drug delivery, J. Control. Rel.   30 (1994) 225-232; DOI: 10.1016/0168-3659(94)90028-0. P. Barthelemy, J.P. Laforet, N. Farah and J. Joachim, Compritolŕ 888 ATO: an innovative hot-melt coating agent for prolonged-release drug formations, Eur. J. Pharm. Biopharm.   47 (1999) 87-90; DOI: 10.1016/S0939-6411(98)00088-5. J. Jung, J. Lee and M. Kim, Colon-specific prodrugs of 5-aminosalicylic acid: synthesis and in vitro/in vivo

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Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets

.3109/03639045.2012.756007. 11. H. Tayebi and S. A. Mortazavi, Formulation and Evaluation of a Novel Matrix-Type Orally Disintegrating Ibuprofen Tablet, Iran J. Pharm. Res. 10 (2011) 469-479. 12. A. Gryczke, S. Schminke, M. Maniruzzaman, J. Beck and D. Douroumis, Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion, Colloids Surf. B Biointerfaces 86 (2011) 275-284. DOI: 10.1016/j.colsurfb.2011.04.007. 13. United States Pharmacopeia, 32nd Revision, United States Pharmacopeia, 2009

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