UV-crosslinkable warm-melt pressure-sensitive adhesives based on acrylics
The target of this article is to show the preparation of new generation of UV-crosslinkable warm-melt acrylic pressure-sensitive adhesives (PSAs) and the experimental test of their adhesive properties in comparison with typical conventional hot-melts adhesives. New generation of UV-crosslinkable acrylic warm-melts PSAs containing unsaturated photoinitiator, incorporated during polymerization process into polymer chain, and photoreactive diluents added to PSA systems after polymerization allows producing of wide range of self-adhesive materials, such as labels, mounting tapes, masking and splicing tapes, and sign and marking films.
Roland Milker, Zbigniew Czech and Marta Wesołowska
Synthesis of photoreactive solvent-free acrylic pressure-sensitive adhesives in the recovered system
The present paper discloses a novel photoreactive solvent-free acrylic pressure-sensitive adhesive (PSA) systems, especially suitable for the so much adhesive film applications as the double-sided, single-sided or carrier-free technical tapes, self-adhesive labels, protective films, marking and sign films and wide range of medical products. The novel photoreactive solvent-free pressure-sensitive adhesives contain no volatile organic compounds (residue monomers or organic solvent) and comply with the environment and legislation. The synthesis of this new type of acrylic PSA is conducted in common practice by solvent polymerisation. After the organic solvent are removed, there remains a non-volatile, solvent-free highly viscous material, which can be processed on a hot-melt coating machine at the temperatures of about 100 to 140°C.
Ahmed Refaat, Magda Sokar, Fatma Ismail and Nabila Boraei
Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.
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Michal Szumilo, Piotr Belniak, Regina Kasperek-Nowakiewicz, Ewelina Holody and Ewa Poleszak
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Emese Sipos, Andrea Ramona Oltean, Zoltán-István Szabó, Emőke-Margit Rédai and Gabriella Dónáth Nagy
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