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Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

) 129–133 56. Liamis G., Milionis H., Elisaf M., A review of drug-induced hyponatremia, Am J Kidney Dis. 2008 Jul;52(1):144-53. 57. Zaremba P.D., Białek M., Błaszczyk B., Cioczek P., Czuczwar S.J., Non-epilepsy uses of antiepileptic drugs, Pharmacological Reports 2006, 58, 1-12, ISSN1734-1140. 58. Kuz G. M., Manssourian A., Carbamazepine-Induced Hyponatremia: Assessment of Risk Factors, Ann Pharmacother. 2005 Nov; 39(11):1943-6. 59. Krysiak R., Okopień B., Hiponatremia spowodowana przez karbamazepinę, Pol Arch Med Wewn. 2007; 117 (4): 193

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Evaluation of Changes in Serum Concentration of Sodium in a Transurethral Resection of the Prostate/ Евалуација На Промените Во Серумската Концентрација На Натриум При Трансуретралнa Ресекција На Простатa


Introduction and objectives: The purpose of this study was to evaluate changes in serum electrolytes during Transurethral resection of the prostate (TURP) and to evaluate the degree of correlation of hyponatremia and the factors that affect the incidence of TURP syndrome and to show the impact of the duration of the procedure on the severity of hyponatremia due to absorption of irrigation fluid in the systemic circulation.

Materials and Methods: This study examined 60 male patients planned for elective TURP. The level of serum electrolytes are determined by taking venous blood samples preoperatively and Postoperatively and when the duration of the operation was longer than 60 minutes, the level of serum electrolytes was determined intraoperative. The amount of used irrigation fluid, the weight of resection prostate, and duration of surgery, were also followed. Patients were divided in two groups according to the length of the surgical procedure: Group 1 (30- 60 min) and Group 2 (> 60 min).

Results: Statistically significant reduction of serum sodium and the elevation of the potassium level in serum observed postoperatively and was directly proportional to the volume of of the used irrigation fluid, the duration of the procedure and volume of the resected prostate.

Conclusions: To evaluate changes in serum electrolyte during TURP is simple and economical method for the indirect estimation of irrigation fluid absorption into the systemic circulation during TURP and opportunity for early identification of TURP syndrome

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Hiponatremia in the practice of a psychiatrist. Part 2: psychogenic polydipsia


Objective. The study is the second part of the literature review on hyponatremia in patients with diagnosed mental disorders. This article focuses on psychogenic polydipsia as, along with the SIADH, one of the two most common causes of hyponatremia in the mentioned group of patients.

Method: The literature review was based on searching the Medline, the Google Scholar and the Ebsco databases in Polish and English by entering the following phrases: psychogenic polydipsia, the psychosis – intermittent hyponatremia – polydipsia syndrome, water intoxication.

Discussion: Psychogenic polydipsia occurs in up to 25% of patients treated for mental disorders. It most frequently concerns patients with schizophrenia. 30% of patients with psychogenic polydipsia suffer from hyponatremia with or without symptoms of water intoxication. In the etiology of psychogenic polydipsia, the influence of dopaminergic and noradrenergic neurotransmission has been considered, as well as angiotensin, which is claimed to have dipsogenic properties. In order to reduce the severity of the disorder, attempts have been made to administer the following groups of medications: β-blockers, opioid receptor antagonists, angiotensin convertase inhibitors and angiotensin receptor antagonists. Other methods include replacing classic antipsychotic drugs with clozapine. There are also reports of a reduced severity of polydipsia with hyponatremia after introducing risperidone and olanzapine. Preventing episodes of water intoxication in patients with psychogenic polydipsia requires the monitoring of their body weight and a suitable reduction of fluid intake by them.

Results: Mentally ill patients, especially those with chronic schizophrenia, should be monitored for psychogenic polydipsia and the concomitant hyponatremia.

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Wenetoklaks w leczeniu chorób układu krwiotwórczego i guzów litych

/oporna PBL + GA małopłytkowość (12%) nowotwory wtórne (6%), zatrucia (8%), choroby naczyniowe (7%) Matthew i wsp. (2017) [ 64 ] MCL DLBCL 1 WEN Niedokrwistość (15%), neutropenia (11%), małopłytkowość (9%) Hiponatremia (3%), grypa (3%), infekcje dolnych dróg oddechowych (3%) Konopleva i wsp. (2016) [ 57 ] OBS 2 WEN Gorączka neutropeniczna (31%) Nudności (59%), biegunka (56%), hipokaliemia (41%), wymioty (41%), osłabienie (34%), bóle głowy (34%), hipomagnezemia (34%), hipofosfatemia (31%), bóle brzucha (28%), kaszel (28%), krwawienia z

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