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Insights into Supplements with Tribulus Terrestris used by Athletes

, Jackson DA, King DS. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30-58 year old men. J Am Coll Nutr, 2001; 20: 520-528 Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, King DS. Endocrine response to chronic androstenedione intake in 30-to 56-year-old men. J Clin Endocrinol Metab, 2000; 85: 4074-4080 Brown GA, Vukovich MD, Reifenrath TA, Uhl NL, Parsons KA, Sharp RL, King DS. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport

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Factors influencing vitamin K antagonists therapy / Factori care influențează terapia cu antagoniști ai vitaminei K


Vitamin K antagonists (VKAs) are widely used for the primary and secondary prevention of thromboembolism, their anticoagulant effect being monitored through INR. Achieving and maintaining a stable anticoagulation status is challenging, because of the narrow therapeutic range, and of the extremely variable individual response to therapy.

Environmental factors such as age, gender, body mass, diet, herbal supplements, drugs, pre-existing pathology, as well as genetic factors can substantially influence the anticoagulant effect of VKAs. The main genetic factors that contribute to individual variability in response to VKAs are genetic polymorphisms in genes influencing VKAs’ metabolism (CYP2C9) and pharmacodynamic response (VKOR1) and account for about one third in the variation of warfarin and analogues dose requirement. Systematic genotyping of patients requiring warfarin therapy is still a matter of debate.

Although novel oral anticoagulants (direct thrombin and factor Xa inhibitors) seem promising, VKAs are still frequently prescribed, therefore physicians should be aware of the various factors influencing VKAs’ effect, and educational programmes for doctors and patients should be conducted in that respect

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Unnecessary Medicine, An Issue With Major Ethical Implications

the Council of Europe (PACE) 15. Marcia Angell, J P Kassirer: Alternative Medicine- The Risks of Untested and Unregulated Remedies NEJM, 1998, 339:839-841) 16. Combest W, Newton M, Combest A, Kosier JH - Effects of Herbal Supplements on the Kidney-Urol Nurs. 2005;25(5):381-386. 17. Vickers A - Cancer Cures: “Unproven or Disproven” CA Cancer J Clin 2004;54:110–118 18. Eldar Reuben: Understanding and Preventing Adverse Events-Croatian Medical Journal, 2002, 43(1):86-88, 19. Soubrie C,Lebrune-Vigne B: Iatrogenie. Diagnostic et prevention

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Effects of Some Herbal Plant Supplements on Growth Performance and the Immune Response in Nile Tilapia (Oreochromis Niloticus)

Muiswinkel W.B., 1996. Immunogenetics of disease resistance in fish: a comparative approach. Dev Comp Immunol., 20:365-381. Yılmaz S., Ergün S., Çelik E.Ş., 2012. Effects of herbal supplements on growth performance of sea bass (Dicentrarchus labrax): Change in body composition and some blood parameters. J. Bio. Sci. Biotech., 1(3):217-222. Yılmaz S., Ergun S., Soytaş N., 2013. Herbal supplements: useful tools for preventing streptococcal disease during first-feeding of tilapia fry, Oreochromis mossambicus. The Israeli Journal of Aquaculture

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Development and Validation of the Questionnaire for the Evaluation of Knowledge about Herbal Preparations (QEK-HP)

. Clement YN, Williams AF, Khan K Et al. A gap between acceptance and knowledge of herbal remedies by physicians: the need for educational intervention. BMC Complement Altern Med 2005; 5:20. 14. Zimmerman C, Kandiah J. A pilot study to assess students’ perceptions, familiarity, and knowledge in the use of complementary and alternative herbal supplements in health promotion. Altern Ther Health Med 2012; 18: 28-33. 15. Marinac JS, Buchinger CL, Godfrey LA et al.. Herbal products and dietary supplements: a survey of use

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Methylxanthine Drugs Are Human Pancreatic Lipase Inhibitors

., Lowe M. E., Val-407 and Ile-408 in the beta 5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. J. Biol. Chem., 2006, 281, 7793-7800. Greenway F. K. de Jonge L., Blanchard D., Frisard M., Smith S. R., Effect of dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition. Obesity Res., 2004, 12, 1152-1157. Grosso L. M., Bracken M. B., Caffeine metabolism, genetics, and perinatal outcomes: A review of exposure assessment

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Comparison of methods for detecting fungi in Silybum marianum (L.) Gaertn. seeds

methods for detecting fungi in Zinnia elegans seeds. Seed. Sci. Technol. 40: 32-42. Tournas V.H., Sapp C., Trucksess M.W., 2012. Occurrence of aflatoxins in milk thistle herbal supplements. Food Addit. Contam. 29(6): 994-999. Wata nabe T., 2002. Pictorial atlas of soil and seed fungi: Morphologies of cultured fungi and key to species. Second Edition. CRC Press, Boca Raton, London, New York, Washington D.C.

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The presence of aeroallergens in food products: a potential risk for the patient with allergic rhinitis

reaction in a woman using an herbal supplement containing ginseng, goldenseal, and bee pollen. J Toxicol Clin Toxicol. 2003;41(6):865-7. 59. Akiyasu T, Paudyal B, Paudyal P, Kumiko M, Kazue U, Takuji N, et al. A case report of acute renal failure associated with bee pollen contained in nutritional supplements. Ther Apher Dial. 2010;14(1):93-7. DOI: 10.1111/j.1744-9987.2009.00707.x. 60. Boppré M, Colegate SM, Edgar JA, Fischer OW. Hepatotoxic pyrrolizidine alkaloids in pollen and drying-related implications for commercial processing of bee pollen. J Agric Food

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Phytotherapeutics oridonin and ponicidin show additive effects combined with irradiation in pancreatic cancer in vitro

a constituent of the herbal supplement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of caspase-3 and mitochondrial events in lung cancer cells in vitro. Cancer Invest 2006; 24 : 136-48. 10.1080/07357900500524371 Liu JJ Huang RW Lin DJ Peng J Zhang M Pan X Ponicidin, an entkaurane diterpenoid derived from a constituent of the herbal supplement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of caspase-3 and mitochondrial events in lung cancer cells in vitro Cancer Invest 2006 24 136 48 10.1080/07357900500524371 15 Liu JJ, Zhang Y

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Contaminants of Medicinal Herbs and Herbal Products

Pharmacopoeia. 6 th ed. Strasbourg: EDQM; 2007. Borwn JC, Jiang X. Prevalence of antibiotic-resistant bacterial on herbal products. J Good Prot 2008;71:1486-90. Kineman B, Nahikian-Nelms ML, Frazier C. A pilot investigation of the microbial contamination of herbal supplements: A potential risk for immunocompromised populations. HIV Nutrition Update 2002;7:1-9. Hauer T, Jonas D, Dettenkofer M, Daschner FD. Tea as a source of Acinetobacter baumannii ventilator-associated pneumonia? Infect

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