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Ocimum Gratissimum Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats

Aim: Hepatoprotective effects of Ethanolic extract Ocimum gratissimum leaves (O. gratissimum) in streptozotocin-induced diabetic rats was studied.

Material and Methods: Thirty-six adult rats were assigned into six groups (A, B, C, D, E and F) of six rats each. Group A was the control, while diabetes was induced in groups B, C, D, E and F. Fasting blood glucose was determined and rats with blood glucose concentration >18.0 mmol/L were considered diabetic. Group A (non diabetic control) and F (diabetic control) received normal saline orally, group B received a Metformin at 25 mg/kg while groups C, D and E had O. gratissimum at 400, 600 and 800 mg/kg. Treatment was daily for a period of 28 days for all groups. Fasting blood glucose was monitored weekly, serum levels of Alanine transaminase (ALT) and Aspartate transaminase (AST) were measured on day twenty eight. Animals were sacrificed, liver sections processed for histological study. Statistical analysis was carried out using a one way ANOVA followed by a post-hoc test.

Results: Results showed reduction in blood sugar and increase in biochemical and histologic markers of hepatic injury.

Conclusion: Ethanolic extract of O. gratissimum causes dose dependent hepatic injury despite its glucose lowering ability.

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and the antioxidant role of zinc. Pestic Biochem Physiol 2010;96:14-23. doi: 10.1016/j.pestbp.2009.08.008 9. Uzun FG, Kalender Y. Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin. Food Chem Toxicol 2013;55:549-56. doi: 10.1016/j. fct.2013.01.056 10. Ncibi S, Othman MB, Akacha A, Krifi MN, Zourgi L. Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver. Food Chem Toxicol 2008;46:797-802. doi: 10.1016/j.fct.2007.08.047 11. Boeira SP, Funck VR, Filho CB, Del’Fabbro L, De Gomes MG

in hepatocytes and regulating the content of GSH in the cells ( 4 , 30 ). The aim of this present study was to investigate whether the administration of propolis to rats would display any protective effects against furan-induced hepatotoxicity by means of evaluating biochemically and histopathologically derived data. Material and Methods Experimental design. A total of 42 healthy male albino Wistar rats (12 weeks old, weighing 250–300 g) were used. Rats were fed a standard rat pellet diet and tap water was provided .ad libitum . Housing conditions were those of a

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Irodalom 1. Grigorian A., O’Brien C.B. – Hepatotoxicity Secondary to Chemotherapy. Journal of Clinical and Translational Hepatology, 2014, 2:95-102. 2. Stirnimann G., Kessebohm K., Lauterburg B. – Liver injury caused by drugs: an update. Swiss Med Wkly 2010, 140:w13080. 3. Xie C., Yue L.J., Ding H., et al. – Correlations between 6-mercaptopurine treatment-related adverse reactions in children with acute lymphoblastic leukemia and polymorphisms of thiopurine methyltransferase gene. Zhongguo Dang Dai Er Ke Za Zhi, 2014, 16(5):499-503. 4. Sharifi M.J., Bahoush G

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