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29 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 LATE RESULTS AFTER CEMENT BONE FILLING IN TREATMENT OF GIANT CELL TUMOUR (GCT) - RETROSPECTIVE STUDY doi: 10.2478/rojost-2018-0040 R. Prejbeanu, D. Crişan, A. Bălănescu, H. Haraguş, B. Deleanu “Victor Babeş” University of Medicine and Pharmacy, Timişoara, Romania Introduction. Segmental or intralesional excision with curettage or complete resection can be one method of treatment for giant cell tumor (GCT), but the ideal filling material after curettage or

References 1. Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ. Giant cell tumor of bone. J Am Acad Orthop Surg. 2013; 21:118-26. 2. Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P et al. Distinct h3f3a and h3f3b driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013; 45:1479-82. 3. Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W. Giantcell tumor of bone. The long-term results of treatment by curettage and bone graft. J Bone Joint Surg (Br). 2004; 86:212-6. 4. Branstetter DG, Nelson SD, Manivel JC et al

19 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 SURGICAL TREATMENT OF GIANT-CELL TUMORS OF THE DISTAL EPIPHYSIS OF THE RADIUS doi: 10.2478/rojost-2018-0030 D. Rădulescu¹,², A. Bădilă¹,², O. Nuțiu², R. Manolescu², T. Ciobanu², I. Japie², R. Rădulescu¹,² 1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Orthopaedics and Traumatology Department, University Emergency Hospital, Bucharest, Romania Introduction. Giant-cell tumor of the bone is a benign tumor, but with high local aggressiveness

52 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 BORDERLINE GIANT CELL TUMORS (GCT) OF PROXIMAL TIBIAL EPIPHYSIS - ONCO-ORTHOPEDIC MANAGEMENT BETWEEN POSSIBILITIES AND LIMITS doi: 10.2478/rojost-2018-0063 R.S. Cismașiu1,2, R.M. Bîrluțiu1,3, A. Tudor1, D. Pop1,2, C.I. Stoica1,2 1”Foișor” Clinical Hospital of Orthopaedics, Bucharest, Romania 2”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 3”Victor Papilian” Faculty of Medicine, ”Lucian Blaga” University, Sibiu, Romania Intralesional

. Giant cell tumor. In: Picci P, Manfrini M, Fabbri N, Gambarotti M, Vanel D, eds. Atlas of musculoskeletal tumors and tumorlike lesions: The Rizzoli Case Archive. 1st ed. Cham, Switzerland: Springer International Publishing; 2014:91-4. 5. Gaston CL, Grimer RJ, Parry M, et al. Current status and unanswered questions on the use of denosumab in giant cell tumor of bone. Clin Sarcoma Res 2016;6(1):15. 6. Goldenberg MM. Pharmaceutical approval update. Pharm Ther 2013;38(8):443-5. 7. Georgiev GP. Clinico-morphological study of giant cell tumour of bone. [PhD thesis], Sofia

11 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 FEMORAL GIANT CELL TUMOR IN A PATIENT WITH SURGICALLY TREATED FEMORAL CONDYLE FRACTURE: MISDIAGNOSIS OR COINCIDENCE? doi: 10.2478/rojost-2018-0022 I.M. Japie1, A. Bădilă1,2, T. Ciobanu1, R. Manolescu1, D. Rădulescu1,2, E.M. Japie3, A. Bujdei1, C. Cîrstoiu1,2 1Department of Orthopaedics and Traumatology, University Emergency Hospital, Bucharest, Romania 2“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 3Department of Pediatric Orthopaedics

63 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 DENOSUMAB TREATMENT IN A RARE, NEGLECTED GIANT CELL TUMOR (GCT) OF THE FEMORAL NECK: CASE REPORT AND LITERATURE REVIEW doi: 10.2478/rojost-2018-0074 R. Marinescu1, D. Lăptoiu 2, I. Botezatu 2, S. Ciumeica 2, A. Bunea 2, G. Ștefan 2 1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2 Colentina Clinical Hospital, Bucharest, Romania Introduction. GCT resembles an aggressive benign tumor of bone and its evolution based on the histological

44 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 GIANT CELL TUMOURS OF THE TENDON SHEATH – PARTICULAR MRI ASPECT doi: 10.2478/rojost-2018-0055 A.M. Bratu1, I.A. Sălcianu1, A.I. Nicula2, C. Zaharia1, A.N. Marinescu2 1Department of Radiology and Medical Imaging, “Colțea” Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Department of Radiology and Medical Imaging, University Emergency Hospital, Bucharest, Romania; “Carol Davila” University of Medicine

zones; appearance of giant cell tumor. The immunohistochemical examination confirmed the anatomopathological diagnosis adding, therefore, the aggressive character and the local relapse. The oncologist decided that it did not require oncology treatment but only orthopedic treatment. Orthopedic treatment required repeated surgery at intervals of about 5 months apart, caused by tumor recurrence. The first intervention consisted of 1/ 3 distal radius resection and replacement with a graft harvested from the peroneum. Tumor recurrence after 5 months required

18 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 SOFT TISSUE GIANT CELL TUMOR - INCIDENCE AND THERAPEUTIC RESULTS doi: 10.2478/rojost-2018-0029 M. Popa1,2, Z. Panti1,2, M. Nica1,2, M. Pleniceanu1, B. Şerban1, R. Ene1,2, C. Cîrstoiu1,2 1Orthopedics and Traumatology Department, University Emergency Hospital, Bucharest, Romania 2“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Introduction. Giant cell tumors of soft tissue (GCTs) have a relatively low incidence and their low prognosis is