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Renin Genetic Polymorphism in Heart Failure Patients

, FILIPPATOS G, MCMURRAY JJ, PONIKOWSKI P, POOLE-WILSON PA, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. Eur Heart J. 2008; 29:2388-2442. 5. World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Technical Report Series 2000; 894: i-xii,1-253. 6. RUPERT JL, KIDD KK, NORMAN LE, MONSALVE MV, HOCHACHKA PW, DEVINE DV. Genetic polymorphisms in the renin-angiotensin system in high altitude and low altitude native American

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Genetic polymorphisms in homologous recombination repair genes in healthy Slovenian population and their influence on DNA damage

mesothelioma. Ann Oncol 2011 Jul 15. [Epub ahead of print]. Dolzan V. Genetic polymorphisms and drug metabolism. Zdrav Vestn 2007; 76 Supll II : 5-12. Strerath M, Marx A. Genotyping-from genomic DNA to genotype in a single tube. Angew Chem Int Ed Engl 2005; 44 : 7842-9. Miklos M, Gajski G, Garaj-Vrhovac V. Usage of the standard and modified comet assay in assessment of DNA damage in human lymphocytes after exposure to ionizing radiation. Radiol Oncol 2009; 43 : 97

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Evaluation of Association Between Q192R and L55M Genetic Polymorphisms of PON1 and Serum Paraoxonase-1 Activity in Healthy Individuals, a Meta-Analysis

. 7. Chen L, Lu W, Fang L et al. Association between L55M polymorphism in paraoxonase 1 and cancer risk: a meta-analysis based on 21 studies. Onco Targets Ther 9: 1151-1158, 2016. 8. You T, Lv J, Zhou L. PON1 Q192R and L55M polymorphisms and organophosphate toxicity risk: a metaanalysis. DNA Cell Biol 32: 252-259, 2013. 9. Saadat M. Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis. Cancer Epidemiol 36: e101-103, 2012. 10. Camps J, Iftimie S, García-Heredia A, Castro A, Joven J

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Genetic Polymorphism of C-262T Catalase and Susceptibility to Schizophrenia

, Ahn J, Stevens VL, Thun MJ, Hong CC. Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk. Carcinogenesis. 2009;30:777-784. 9. Bohanec Grabar P, Logar D, Tomsic M, Rozman B, Dolzan V.Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients. Dis Markers. 2009;26:41-48. 10. Zarbock R, Hendig D, Szliska C, Kleesiek K, Götting C.Pseudoxanthoma elasticum: genetic variations in antioxidant genes are risk factors for early disease onset. Clin

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Increased Prevalence of the IL-6 -174C Genetic Polymorphism in Long Distance Swimmers

available for possible talent identification, several may be considered as inherited traits. These traits include obviously aspects of body size and proportions, maturity onset and the type of muscle fiber (e.g. fast or slow). Several genetic polymorphisms and profiles have been suggested to promote athletic excellence in endurance ( Ben-Zaken et al., 2013 ; Ruiz et al, 2009 ; Williams and Folland, 2008 ) and power sports ( Ben-Zaken et al., 2013 ; Ruiz et al., 2010 ). However, whether genetic polymorphisms that affect the athlete’s ability to tolerate training loads

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Asbestosis and Catalase Genetic Polymorphism

;52:20-7. Franko A, Dodic-Fikfak M, Arneric N, Dolzan V. Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. J Occup Environ Med 2007;49:667-71. Jakobsson K, Rannung A, Alexandrie AK, Rylander L, Albin M, Hagmar L. Genetic polymorphism for glutathione-S-transferase mu in asbestos cement workers. Occup Environ Med 1994;51:812-6. Smith CM, Kelsey KT, Wiencke JK, Leyden K, Levin S, Christiani DC. Inherited glutathione-S-transferase deficiency is a risk factor for pulmonary asbestosis. Cancer Epidemiol

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Matrix metalloproteinases polymorphisms as baseline risk predictors in malignant pleural mesothelioma

additive and dominant genetic models were used in statistical analyses. The associations of genetic polymorphisms with MM risk were examined by logistic regression to calculate odds ratios (ORs) and their 95% confidence intervals (CIs). All statistical analyses were carried out by IBM SPSS Statistics, version 21.0 (IBM Corporation, Armonk, NY, USA). Haplotypes were reconstructed and analysed using Thesias software, version 3.1. The most frequent haplotype was used as the reference. All statistical tests were two sided and the level of significance was set to P = 0

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Genetic polymorphisms of hemostatic factors and thrombotic risk in non BCR-ABL myeloproliferative neoplasms: A pilot study


The most important complications of Philadelphianegagive (non BCR-ABL) myeloproliferative neoplasms (MPNs) are vascular events. Our aim was to evaluate the effects of single nucleotide polymorphisms (SNPs), platelet glycoproteins (GPs) (Ia/IIa, Ibα, IIb/IIIa and VI), von Willebrand factor (vWF), coagulation factor VII (FVII), β-fibrinogen, and the risk of thrombosis in patients with non BCR-ABL MPNs at the Lithuanian University of Health Sciences. Kaunas, Lithuania. Genotyping was done for 108 patients. The TT genotype of the GP Ia/IIa c.807C>T polymorphism was more frequently found in the group of MPN patients with arterial thrombosis compared to MPN patients who were thrombosis-free [26.5 vs. 11.5%, p = 0.049; odds ratio (OR) 2.68; 95% confidence interval (95% CI) 1.01-7.38]. The CT genotype of the β-fibrinogen c.-148C>T polymorphism occurred more frequently in MPN patients with arterial, and total thrombosis compared to the wild or homozygous genotype (57.7 vs. 40.0 vs. 12.5%; p = 0.027), (64.7 vs. 44.4 vs. 25%; p = 0.032), respectively. The carrier state for the c.-323P10 variant of FVII SNP (summation of P10/10 and P0/10) was more frequent in MPN patients with thrombosis compared to the wild-type genotype carriers (71.4 vs. 43.4%; p = 0.049; OR 3.26; 95% CI 1.01-11.31). The coexistence of heterozygous β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP, increased the risk of arterial thrombosis (21.1 vs. 3.7%, p = 0.008; OR 6.93; 95% CI 1.38-34.80). The TT genotype of GP Ia/IIa c.807C>T, the CT genotype of β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP could be associated with risk of thrombosis in MPN patients.

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Association between the TP53 and CYP2E1*5B gene polymorphisms and non-small cell lung cancer

cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis. Front Biosci 2007;12:4497-503. PMID: 17485391 14. Watanabe J, Hayashi S, Nakachi K, Imai K, Suda Y, Sekine T, Kawajiri K. PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E gene. Nucleic Acids Res 1990;18:7194. PMID: 1979861 15. Hayashi S, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5’-flanking region change transcriptional regulation of the human cytochrome P450IIE1

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Characterization of morphological traits and RAPD polymorphism in selected forms of Kentucky bluegrass (Poa pratensis L.)

., Zhang Z. J., Jin C. Z. & Zhu Y. G. 2005. Genetic polymorphism of bluegrass cultivars detected by RAPDs. Hereditas 27(4): 605-610. Pamilo P., Nei M. & Li W. H. 1987. Accumulation of mutations in sexual and asexual populations. Genet. Res. 43: 135-146. DOI: 10.1017/S0016672300026938 Patterson J. T., Larson S. R. & Johnson P. G. 2005. Genome relationships in polyploidy Poa pratensis and other Poa species inferred from phylogenetic analysis of nuclear and chloroplast DNA sequences. Genome 48: 76-87. Pavlíček A., Hrdá Š

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