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Urinary exosomes from a mouse model of chronic tubulointerstitial kidney disease induced by chronic renal ischemia–reperfusion injury and nephrectomy

an important prognostic factor in several types of CKD and is associated with a decrease in kidney function [ 3 ]. Despite the common prevalence of renal TI fibrosis in CKD regardless of etiology, known biomarkers of TI fibrosis are limited. The current well-known biomarker of CKD, albuminuria, is more associated with glomerulosclerosis than TI fibrosis. The exosome, a 35–40 nm plasma membrane enriched vesicle secreted by various cell types, is a source of interesting biomarkers [ 4 ]. The urinary exosome markers for early TI fibrosis should be beneficial as

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Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment

REFERENCES 1. Admyre, C., Grunewald, J., Thyberg, J., Gripenbäck, S., Tornling G., Eklund A., 2003: Exosomes with major histo-compatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur. Respir. J. , 22, 578—583. 2. Bruno, S., Grange, C., Deregibus, M. C., 2009: Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J. Am. Soc. Nephrol. , 20, 1053—1067. 3. Caby, M. P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., Bonnerot, C., 2005: Exosomal-like vesicles are present in

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Therapeutic Potential of “Exosomes Derived Multiple Allogeneic Proteins Paracrine Signaling: Exosomes d-MAPPS” is Based on the Effects of Exosomes, Immunosuppressive and Trophic Factors

;22:2990e3002. 19. Kode JA, Mukherjee S, Joglekar MV, Hardikar AA. Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 2009;11:377e91. 20. Tao H, Han Z, Han ZC, Li Z. Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications. Stem Cells Int 2016;2016:1314709. 21. Harrell CR, Simovic Markovic B, Fellabaum C, Arsenijevic A, Djonov V, Arsenijevic N, Volarevic V. Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Eye Diseases. Adv Exp Med Biol 2018

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The role of tumor-derived exosomes in tumor angiogenesis and tumor progression

References 1. Zaborowski MP, Balaj L, Breakefield XO, Lai CP. Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study. Bioscience . 2015;65(8):783-97. 2. Ribeiro MF, Zhu H, Millard RW, Fan GC. Exosomes Function in Pro- and Anti-Angiogenesis. Curr Angiogenes . 2013;2(1):54-9. 3. Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998

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A folic acid-induced rat model of renal injury to identify biomarkers of tubulointerstitial fibrosis from urinary exosomes

detection of TI fibrosis using a noninvasive approach would offer a significant advantage in its diagnosis. One such approach involves the detection of disease biomarkers that have been released into body fluids as either intact cells or cellular components, a so-called liquid biopsy [ 4 ]. Cellular components called exosomes, 30-100 nm membrane vesicles secreted from several cell types, are a rich source of potential biomarkers in urine [ 5 , 6 ]. Several types of molecules that are easily degraded in the extracellular environment, such as transcription factors and

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Oral cavity-derived exosomes as promising tool in chronic wound healing

reaction to the treated patient. First of all, mechanisms of action should be identified, since they are still not well understood. The long-term safety profile should be investigated as there are currently no sources suggesting long-term stem cell treatment. Differentiation into many types of cells is somewhat limited, which means that they can only be applied to designated types of wounds [ 11 ]. Therapy with the use of exosomes The solution to the problem above seems to be the use of molecules presenting high therapeutic safety, which are exosomes. They are shed

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Micro RNAs: an arguable appraisal in medicine

://dx.doi.org/10.1073/pnas.0912186107 Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494−498, 2001. http://dx.doi.org/10.1038/35078107 Escrevente C, Keller S, Altevogt P, Costa J. Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer 11, 108, 2011. http://dx.doi.org/10.1186/1471-2407-11-108 Etheridge A, Lee I, Hood L, Galas D, Wang K. Extracellular microRNA: a new source of biomarkers. Mutat Res 717

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Exo-D-MAPPS Attenuates Production of Inflammatory Cytokines and Promoted Generation of Immunosuppressive Phenotype in Peripheral Blood Mononuclear Cells

stem cells. Stem Cells Dev. 2007; 16: 931-952. 21. Mareschi K, Castiglia S, Sanavio F, Rustichelli D, Muraro M, Defedele D, Bergallo M, Fagioli F. Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta. Exp Hematol. 2016; 44: 138-150.e1. 22. Harrell CR, Fellabaum C, Simovic Markovic B, Arsenijevic A, Volarevic V. Therapeutic potential of “Exosomes derived Multiple Allogeneic Proteins Paracrine Signaling: Exosomes d-MAPPS” is based on the effects of exosomes, immunosuppressive

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Ovarian follicular cells - living in the shadow of stemness cellular competence

Introduction Granulosa cells (GCs), otherwise known as ovarian follicular cells, are the largest component of follicular fluid [ 1 ]. Alongside GCs are theca cells, ovarian surface epithelial (OSE) cells, and oocytes. Together, the Graafian follicle will form to protect the oocyte (folliculogenesis) and germ cells also mature into an egg (oogenesis) [ 2 , 3 ]. Granulosa cells have small cell-secreted vesicles called exosomes which are essential in mediating communication between cells, and they share this role with gap junctions [ 4 ]. Exosomes secrete small

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No Definite Evidence for Human Endogenous Retroviral HERV-W and HERV-H RNAS in Plasma of Latvian Patients Suffering from Multiple Sclerosis and Other Neurological Diseases / Nav Apstiprinošu Pierādījumu Par Endogēno Retrovīrusu HERV-W Un HERV-H Rns Sastopamību Latvijas Pacientu Ar Multiplo Sklerozi Un Citām NeiroloĢiskām Slimībām Asins Plazmā

amplification of low copy number DNA. J. Forensic Sci., 51 (4), 790-794. Thery, C., Amigorena, S., Raposo, G., Clayton, A. (2006). Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol., Chapt. 3, Unit 3 22. Thompson, J. D., Higgins, D. G., Gibson, T. J. (1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22 (22), 4673-4680. Available at

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