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Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results

poisoning in severely intoxicated Iranian veterans. Fundam Clin Pharmacol   19 : 713-721. Bestor TH (2000) The DNA methyltransferases of mammals. Hum Mol Genet   9 : 2395-2402. Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev   16 : 6-21. Bombail V, Moggs JG, Orphanides G (2004) Perturbation of epigenetic status by toxicants. Toxicol Lett   149 : 51-58. Bronner C, Chataigneau T, Schini-Kerth VB, Landry Y (2007) The "Epigenetic Code Replication

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Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)

, Grossrubatscher E, Reimondo G, Arnaldi G, Giacchetti G, Veglio F, Loli P, Colao A, Ambrosio MR, Terzolo M, Letizia C, Ercolino T, Opocher G; Italian heochromocytoma/Paraganglioma Network. Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas. J Clin Endocrinol Metab 94, 1541-1547, 2009. Margetts CD, Morris M, As tuti D, Gentle DC, Cascon A, McRonald FE, Catchpoole D, Robledo M, Neumann HP, Latif F, Maher ER. Evaluation of a functional epigenetic approach to identify

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Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity

trial organized by the Swedish Society for Pulmonary Diseases. Eur J Respir Dis   64 : 405-15. Bombail V, Moggs JG, Orphanides G. (2004). Perturbation of epigenetic status by toxicants. Toxicol Lett   149 : 51-8. Campbell KJ, Rocha S, Perkins ND. (2004). Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell   13 : 853-65. Ceriello A. (2006). Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes. Curr Opin

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. The ENCODE (ENCyclopedia of DNA elements) project. Science 2004; 306: 636-40. 5. Dunham I, Birney E, Lajoie BR, Sanyal A, Dong X, Greven M, et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012; 489: 57-74. 6. Goldberg AD, Allis CD, Bernstein E. Epigenetics: a landscape takes shape. Cell 2007; 128: 635-8. 7. Szyf M, McGowan P, Meaney MJ. The social environment and the epigenome. Environ Mol Mutagen 2008; 49: 46-60. 8. Rodríguez-Paredes M, Esteller M. Cancer epigenetics

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The effect of a rat diet without added Cu on redox status in tissues and epigenetic changes in the brain

copper nanoparticles and copper (II) salt on redox reactions and epigenetic changes in a rat model. J. Anim. Physiol. Anim. Nutr. (Berl.), 103: 675–686. Opazo C.M., Greenough M.A., Bush A.I., (2014). Copper: from neurotransmission to neuroproteostasis. Front. Aging Neurosci., 6: 143. Paglia D.E., Valentine W.N., (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 70(1): 158-169. Palumaa P., (2013). Copper chaperones. The concept of conformational control in the metabolism of

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Epigenetic alterations in patients with type 2 diabetes mellitus

genome. Therefore, it is likely that environmental factors, such as diet and sedentary lifestyle, might play a significant role in the development of the disease. The role of epigenetic factors in the gene environment interactions pointed to epigenetics as a possible molecular link between environmental factors and T2DM. Previous studies have shown that epigenetic mechanisms can predispose individuals to the diabetic phenotype. Conversely, the altered homeostasis in T2DM, such as prolonged hyperglycemia, dyslipidemia and increased oxidative stress could also cause

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Can Reprogramming of Overall Epigenetic Memory and Specific Parental Genomic Imprinting Memory within Donor Cell-Inherited Nuclear Genome be a Major Hindrance for the Somatic Cell Cloning of Mammals? – A Review

References Agrawal H., Selokar N.L., Saini M., Singh M.K., Chauhan M.S., Palta P., Sin-gla S.K., Manik R.S. (2018). Epigenetic alteration of donor cells with histone deacetylase inhibitor m-carboxycinnamic acid bishydroxymide improves the in vitro developmental competence of buffalo (Bubalus bubalis) cloned embryos. Cell. Reprogram., 20: 76-88. Allegrucci C., Thurston A., Lucas E., Young L. (2005). Epigenetics and the germline. Reproduction, 129: 137-149. Anckaert E., Fair T. (2015). DNAmethylation reprogramming

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Acute and delayed sulfur mustard toxicity; novel mechanisms and future studies

) Perturbation of epigenetic status by toxicants. Toxicol Lett   149 : 51-58. Cui P, Luo Z, Zhang H, Su Y, Li A, Li H, Zhang J, Yang Z, Xiu R. (2006) Effect and mechanism of melatonin's action on the proliferation of human umbilical vein endothelial cells. J Pineal Res   41 : 358-362. Deng WG, Tang ST, Tseng HP, Wu KK. (2006) Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. Blood   108 : 518-524. Dugo L

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Triassic fluid mobilization and epigenetic lead-zinc sulphide mineralization in the Transdanubian Shear Zone (Pannonian Basin, Hungary)


A combined fluid inclusion, fluid inclusion plane, lead isotope and K/Ar radiometric age dating work has been carried out on two lead-zinc mineralizations situated along the Periadriatic-Balaton Lineament in the central part of the Pannonian Basin, in order to reveal their age and genetics as well as temporal-spatial relationships to other lead-zincfluorite mineralization in the Alp-Carpathian region. According to fluid inclusion studies, the formation of the quartzfluorite- galena-sphalerite veins in the Velence Mts is the result of mixing of low (0-12 NaCl equiv. wt. %) and high salinity (10-26 CaCl2 equiv. wt. %) brines. Well-crystallized (R3-type) illite associated with the mineralized hydrothermal veins indicates that the maximum temperature of the hydrothermal fluids could have been around 250 °C. K/Ar radiometric ages of illite, separated from the hydrothermal veins provided ages of 209-232 Ma, supporting the Mid- to Late-Triassic age of the hydrothermal fluid flow. Fluid inclusion plane studies have revealed that hydrothermal circulation was regional in the granite, but more intensive around the mineralized zones. Lead isotope signatures of hydrothermal veins in the Velence Mts (206Pb/204Pb = 18.278-18.363, 207Pb/204Pb = 15.622-15.690 and 208Pb/204Pb = 38.439-38.587) and in Szabadbattyán (206Pb/204Pb = 18.286-18.348, 207Pb/204Pb = 15.667-15.736 and 208Pb/204Pb = 38.552-38.781) form a tight cluster indicating similar, upper crustal source of the lead in the two mineralizations. The nature of mineralizing fluids, age of the fluid flow, as well as lead isotopic signatures of ore minerals point towards a genetic link between epigenetic carbonate-hosted stratiform-stratabound Alpine-type lead-zinc-fluorite deposits in the Southern and Eastern Alps and the studied deposits in the Velence Mts and at Szabadbattyán. In spite of the differences in host rocks and the depth of the ore precipitation, it is suggested that the studied deposits along the Periadriatic-Balaton Lineament in the Pannonian Basin and in the Alps belong to the same regional scale fluid flow system, which developed during the advanced stage of the opening of the Neo-Tethys Ocean. The common origin and ore formation process is more evident considering results of large-scale palinspastic reconstructions. These suggest, that the studied deposits in the central part of the Pannonian Basin were located in a zone between the Eastern and Southern Alps until the Early Paleogene and were emplaced to their current location due to northeastward escape of large crustal blocks from the Alpine collision zone

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Epigenetic aspects in schizophrenia etiology and pathogenesis

. Quina AS, Buschbeck M, Di Croce L. Chromatin structure and epigenetics. Biochem Pharmacol 2006;72(11):1563-9. 9 Chakravarthy S, Park YJ, Chodaparambil J, Edayathumangalam RS, Luger K. Structure and dynamic properties of nucleosome core particles. FEBS Lett 2005;579(4):895-8. 10. Robinson PJ, Rhodes D. Structure of the ‘30 nm’ chromatin fibre: a key role for the linker histone. Curr Opin Struct Biol 2006;16(3):336-43. 11. Berger SL. The complex language of chromatin regulation during transcription. Nature 2007; 447

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