Aliya Aryzbekova, Konrad Tomasz Juszkiewicz, Donald Eduard Burgess, Andrzej Polski and Ewa Poleszak
Peptic ulcers are a serious problem worldwide, and affect about 4 million people each year. Their etiology is connected with the presence of Helicobacter pylori, the act of smoking, drinking alcohol, being stress, and taking excessively nonsteroidal anti-inflammatory drugs, as well as steroids. The most common symptoms are abdominal pain, nausea, chest pain and fatigue, while less frequent symptoms include vomiting and weight loss. Helicobacter pylori is responsible for about 80% of gastric and 90% of duodenal ulcer cases. In this work, an analysis is made of a correlation between stomach or duodenal ulcer and gender, residence and number of patients hospitalized in the Almaty hospital №1, from 2009-2012, in order to learn about trends in the incidence of these diseases in Kazakhstan. A total number of 950 patients with stomach and duodenal ulcers, in 2009-2012, were questioned. The patient’s residence, gender and stomach or duodenal ulcer problem were taken into account in the study. The result of this work reveals that the largest amount of hospitalized patients suffering from stomach or duodenal ulcers came from urban areas. Moreover, more women than men suffered from peptic ulcers. Furthermore, the number of patients admitted to the hospital due to duodenal ulcers did not show any variation throughout the study. However, the least number of patients suffering from gastric ulcers was noticed in December 2009, and the greatest was in October and November 2011. The obtained data show that ulcers are a serious problem in Kazakhstan.
Cotirleţ A., Tincu E., Coşa Raluca, Popa E., Gavril Laura, Unc O. and Iordache I.
1. Koo J., Ngan Y.K. & Lam S.K. (1983). Trends in hospital admissions, perforation and mortality of peptic ulcer in Hong Kong from 1970 to 1980. Gastroenterology. 84(6), 1558-62.
2. Alagaratnam T.T. & Wong J: (1988). No decrease in duodenalulcer surgery after cimetidine in Hong Kong. J Clin Gastroenterol , 10:25-27
3. Hopkins R.J., Girardi L.S. & Turney E.A. (1996). Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology . 110 , 1244-1252.
4. Lam S.K., Byth K
Ibtesam Khalid Salih, Ali Malik Sheya’a, Qays Ahmed Hassan and Ayad Khani Mykhan
19. Marotta RB, Floch MH. Diet and nutrition in ulcer disease. Med Clin North Am 1991;75:967-97 https://doi.org/10.1016/S0025-7125(16)30424-2
20. Ahmed ME, AL-Knawy BA, AL-Wabel AH, et al. Duodenalulcer and helicobacter pylori infection at high altitude: experience from southern Saudi Arabia. Can. J. Gastroenterol 1997;11:313-16. https://doi.org/10.1155/1997/589701
21. Jaff MS. Relation between ABO blood groups and Helicobacter pylori infection in symptomatic patients. Clin. Exp. Gastroenterol 2011;4:221-6. https://doi.org/10
Anca Negovan, Septimiu Voidăzan, Monica Pantea, Valeriu Moldovan, Simona Bataga, Laurentiu Cozlea, Simona Mocan and Claudia Banescu
Genetic factors may play a role in prediction of gastrointestinal side effects of aspirin, one of the most used drugs worldwide. We aim to determine a possible correlation between AGT A-20C (rs5050) gene polymorphism and gastro-duodenal ulcer in patients taking low-dose aspirin, adjusted for clinical and histological characteristics.
Results. We enrolled 211 patients stratified according to AGT A-20C genotype: 122 AA, 83 AC and 6 CC patients. There were no significant differences regarding demographical and clinical parameters, except for the frequency of ulcers (4%, 8.4% respective 50%, p=0.03), endoscopic bleeding signs (12.3%, 14.5% respective 50%, p=0.0001) and the frequency of gastritis in biopsy (63.9%, 54.2% respective 16.7%, p=0.03) in genotype groups. When we compared ulcer and non-ulcer group, variant homozygous CC genotype carried an increased risk for ulcer (OR:9.66, 95% CI: 1.46-63.7, p=0.04) than AA group, as well as variant C allele compared with normal A allele (OR: 2.12, 95% CI: 1.07-4.63, p=0.04). On multivariate analysis, variant homozygous CC genotype AGT A-20C showed an OR: 12.32 (95% CI:1.40 -108.13, p=0.02) for ulcer, while H. pylori infection (OR:2.40, 95% CI:1.18 -6.54, p=0.04) and concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs) (OR:1.31, 95% CI:1.07 - 2.27, p=0.05) remained predictors for ulcer in aspirin consumers.
Conclusions. Variant C allele and variant homozygous CC genotype AGT A-20C, infection with H. pylori and NSAIDs co-treatment are risk factors for gastro-duodenal ulcer in low-dose aspirin consumers. The variant homozygous CC genotype AGT A-20C patients treated with LDA are more prone to have reactive gastropathy and bleeding ulcers in a population with a high prevalence of H. pylori infection
Background: Upper gastrointestinal (UGI) endoscopy is a safe and sensitive investigation in the diagnosis of upper gastrointestinal disease. There are few reports on endoscopy in private institutions in Nigeria; therefore we decided to report our early experience in a private health facility in Lagos, Nigeria.
Aim: This study aims to document the indications and common findings in UGI endoscopy and evaluate the relationship between H pylori and endoscopic findings.
Methods: The indications for UGI endoscopy and findings detected over a 3-year period were analyzed.
Results: The commonest symptoms were epigastric pain, other upper abdominal pain, and dyspepsia while common signs were epigastric and right upper quadrant tenderness, and epigastric mass. Complete data was obtained in 172 patients of which 114 had abnormal findings. The commonest were duodenal ulcer, gastritis and duodenitis. Less common findings were gastric ulcer, gastric cancer and oesophageal cancer. There was no significant difference in the frequency of H. pylori infection between those with normal and abnormal endoscopic findings.
Conclusion: The commonest indication for UGI endoscopy in Lagos, Nigeria is dyspepsia while the commonest endoscopic abnormalities are duodenal ulcer, gastritis and duodenitis
Irinel-Raluca Parepa, Andra-Iulia Suceveanu, A. P. Suceveanu, Laura Mazilu, B. Cîmpineanu and Elvira Craiu
Upper endoscopy is the “golden standard” for the diagnosis of upper gastrointestinal bleeding (UGB); it appreciates the persistence of bleeding in more than 90% of cases, it reveals the UGB lesion, gives prognostic information about re-bleeding risk and offers the possibility of endoscopic haemostasis. Uncomplicated STEMI by itself is not a contraindication for upper endoscopy [1,2]. The aim of our study was to observe the haemorrhagic lesions in STEMI patients with postthrombolysis UGB and to evaluate the safety and therapeutic utility of upper endoscopy in this category of patients. We performed upper endoscopy in STEMI patients with postthrombolytic UGB during a period of 4 years (1st of Jan 2008 - 31st of Dec 2011). Patients with systolic blood pressure (SBP) <100 mmHg, with Killip class>1, with unstable ECG and/or with severe associated conditions (respiratory distress, cerebrovascular stroke, consciousness disorders) were withdrawn from undergoing upper endoscopy, as well as patients who refused the investigation. During studied period, 618 STEMI patients underwent pharmacological coronary reperfusion. Postthrombolysis UGB occurred in 42 of them (6.79%). We could perform upper endoscopy in 30 patients (71.43%), the rest of 12 (28.57%) being withdrawn from endoscopy (6 patients with Killip class>1, 4 patients with systolic blood pressure<100mmHg, 2 patients refused the investigation). Incriminated haemorrhagic lesions were: erosive gastroduodenitis in 20 cases (66.67%) and duodenal ulcer in 10 cases (33.33%). As about therapeutic utility, amongst 30 patients investigated just 4 needed endoscopic treatment (haemoclips used in Forrest IB patients with duodenal ulcers). Endoscopy was a safe investigation in STEMI patients with postthrombolysis UGB. Erosive gastroduodenitis was incriminated as the source of bleeding in most of the cases. As it concerns the therapeutic utility of UE in STEMI patients with UGB, 13.33% of bleeding patients benefited from endoscopic treatment (mechanical haemmostasis).
Piotr Chmielewski, Bartłomiej Strzelec, Jolanta Chmielowiec, Krzysztof Chmielowiec and Krzysztof Borysławski
In elderly people, anemia occurs with increasing frequency with each advancing decade and can be a harbinger of very serious health conditions, including gastrointestinal bleeding, gastric and duodenal ulcers, and cancer. Therefore, age-dependant changes in hematological parameters deserve special attention. Nonetheless, very few longitudinal studies of aging have focused on possible associations between basic anthropometric characteristics and hematological parameters in older people. Here, we present some evidence that body size can be associated with red blood cell count as well as some other selected hematological parameters in adults aged 45 to 70 years. Longitudinal data on anthropometric and hematological parameters have been obtained from physically healthy residents at the Regional Psychiatric Hospital for People with Mental Disorders in Cibórz, Lubuskie Province, Poland (142 individuals, including 68 men and 74 women). The residents who took psychoactive drugs were excluded from the study. To evaluate the studied relationships, three anthropometric traits were used and three dichotomous divisions of the study sample were made. The medians of body height, body weight, and body mass index at the age of 45 years were used to divide the sample into: shorter and taller, lighter and heavier, and slimmer and stouter individuals, respectively. Student’s t-test, Pearson’s correlation, and regression analysis were employed. The results of the present study suggest that the relationship between body size and red blood cell count is slightly more pronounced in men and its strength depends on age. However, the correlations between body size and red blood cell count proved to be weak in both sexes. With aging, the strength of the relation decreased gradually, which might have been caused by the aging-associated changes in the hematopoietic system, anemia, or was an artifact. Further studies are needed to elucidate the unclear association between body size and hematological parameters in older adults.
Margarita Vyzhigina, Viktor Titov, Svetlana Zhukova and Oksana Kurilova
., Dowse, G. K., Gareeboo, H. (1996). Incidence, increasing prevalence, and predictors of change in obesity and fat distribution over 5 years in the rapidly developing population of Mauritius. Int. J. Obes. Relat. Metab. Disord. , 20(2), 137-146.
Postlethwait, R. W., Johnson, W. D. (1992). Complications following surgery for duodenalulcer in obese. Arch. Surg. , 105, 438.
Бутрова С. А. Ожиренеие (этиология, патоенез, классификация) [Obesity (ethiology, pathogenesis, classification)]. В кн. Ожuренuе. Mema
Sakolwan Suchartlikitwong, Kamolyut Lapumnuaypol, Rungsun Rerknimitr and Duangporn Werawatganon
data were calculated using SPSS Statistics version 17.0 (SPSS, Chicago, IL, USA). Chi-square and Student t tests were used to analyze the categorical and quantitative data respectively.
Etiologies were classified into 10 groups: gastric ulcer, duodenalulcer, concurrent gastroduodenal ulcer, nonulcer-mucosal lesion, esophageal-related cause, cirrhosis, concurrent peptic ulcer disease with cirrhosis, malignancy, vascular lesion, and miscellaneous ( Table 1 ) . Nonulcer-mucosal lesions included gastritis, duodenitis, gastric erosion, duodenal erosion