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Impact of Probiotic on the Number of Lactic Acid Rods Forming Hydrogen Peroxide Isolated From Porkers and on Changes in Drug Resistance of Selected Escherichia Coli Isolates

-9. 9. Klebanoff S.J., Hillier S.L., Eschenbach D.A., Waltersdorph A.M.: Control of microbial flora of the vagina by H2O2-generating lactobacilli. J Infect Dis 1991, 164 , 94-100. 10. Mazur E., Klag S.: Mechanisms of antimicrobial resistance. Med Rodzinna 2004, 6 , 278-281. 11. Ogunbanawo S.T.: Functional properties of lactic acid bacteria isolated from ogi and fufu, two Nigerian fermented foods. Adv Food Sci 2005, 27 , 14-21. 12. Osek J.: Drug resistance of Escherichia coli strains of O157:H7 group isolated from

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Impact of the Priobiotic on the Presence of Selected Virulence Genes and Drug-Resistance Among Campylobacter Coli Isolated from Piglets

Food Safety 2010, 12 , 1531-1536. 15. Rzedzicki J., Kołodziejczyk A.: Birds as a potential source of human infection by Campylobacter sp. Medycyna Wet 1998, 54 , 511-514. 16. SAS User’s quide. Statistics version. 1999, SAS Inst Inc Cary NC. 17. Tambur Z.Ž., Stojanov I.M., Konstantinonic S.M., Jovanowic D.V., Cenic-Miloševic D., Opačic D.N.: Multi drug resistance of Campylobacter jejuni and Campylobacter coli to tested antibiotics in strains originating from humans, poultry and swine. Matica Srpska Proceed

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Comparison of in-house HIV-1 genotypic drug resistant test with commercial HIV-1 genotypic test kit

References 1. Jenwitheesuk E, Watitpun C, Vibhagool A, Chantratita W. Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002. Ann Clin Microbiol Antimicrob. 2003; 2:4. 2. Sukasem C, Churdboonchart V, Sirisidthi K, Riengrojpitak S, Chasombat S, Watitpun C, et al. Genotypic resistance mutations in treatment-naive and treatment-experienced patients under widespread use of antiretroviral drugs in Thailand: implications for further epidemiologic surveillance. Jpn J Infect Dis. 2007; 60:284-9. 3. Puthanakit T

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Antiviral Combination Approach as a Perspective to Combat Enterovirus Infections

, Herrmann JA. A working hypothesis - virus resistance development as an indicator of specific antiviral activity. Ann NY Acad Sci. 1977; 284: 632-637. Herrmann EC Jr, Herrmann JA, DeLong DC. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982; 2: 339-346. Hyoty H, Taylor KW. The role of viruses in human diabetes. Diabetologia. 2002; 45: 1353-1361 Loddo B. Development of drug resistance and dependence in viruses. Pharm Ther. 1980; 10: 431

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Drug resistance to anti-tuberculotics in children - three years status in Slovakia

. Factors Associated with Multidrugresistant Tuberculosis: Comparison of Patients Born Inside and Outside of the Czech Republic. The Journal of International Medical Research 2010; 38: 1156-63. 18. WHO IUATALD. Anti-tuberculosis drug resistance in the world:third global report. Geneva: World Health Organization, 2004: 299. 19. Zignol M, Hosseini MS, Wright A, Lambregts–van Weezenbeek C, Nunn P, Watt CJ, Williams BG, Dye C. Global incidence of multidrug-resistant tuberculosis. J Infect Dis 2006; 194:479–85.

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Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy

Introduction Drug resistance is a wide spread and well known phenomenon among anticancer medications and platinum drugs are not exceptions. The use of these drugs in chemotherapy is hampered by extrinsic and intrinsic resistance of cells. Although many cancer cells are initially susceptible to chemotherapy with platinum drugs, over time they may develop resistance through more efficient DNA damage repair, drug inactivation with glutathione and metallothioneins and drug efflux with various transport systems located in cell membrane. In this review the chemical

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Whole-Genome Sequencing in Relation to Resistance of Mycobacterium Tuberculosis

REFERENCES 1. World Health Organisation. Global Tuberculosis Report 2017. Geneva: WHO; 2017. 2. Brossier F, Guindo D, Pham A, et al. Performance of the New Version (v2.0) of the GenoType MTBDRsl Test for Detection of Resistance to Second-Line Drugs in Multidrug-Resistant Mycobacterium tuberculosis Complex Strains. J Clin Microbiol. 2016;54(6):1573-1580. 3. Porvaznik I, Mokry J, Solovic I. Drug resistance to anti-tuberculotics in children – three years status in Slovakia. Acta Medica Martiniana 2013, 13(3): 18-22 4. Dheda K, Gumbo T

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The emergence of lincosamide and macrolide resistance in Streptococcus pyogenes from Pakistan

. To our knowledge this is the first comprehensive report of the prevalence and the antibiotic resistance pattern of GAS from Pakistan. Furthermore, this study may help in discouraging the misuse of antibiotics that leads to the emergence in drug resistance. Materials and methods Collection of S. pyogenes strains This study was performed in the Department of Microbiology, University of Karachi from July 2013 to June 2014. To obtain strains and basic patient information such as sex, age, specimen and disease, assistance was obtained from laboratories

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Monitoring of Frequency and Antimicrobial Susceptibility of Pathogens on the Hands of Healthcare Workers in a Tertiary Hospital


Objective: To monitor microbes, focusing on drug resistance, on the hands of the personnel of four departments of a tertiary hospital (ICU, neonatal unit, internal medicine ward and surgical ward) and explore differences between departments, professions and genders.

Materials and methods: Hand sampling from 125 healthcare employees was conducted followed by isolation, identification and antibiotic resistance profiling of different microbial species.

Results: Staphylococcus spp was the most prevalent microbe (76/125, 60.8%), followed by different Gram-negative pathogens (45.6%). ICU employees had a significant probability to have Gram-negative contamination [OR 3.627 (95% CI 1.220-10.782)], independently of gender or profession. Staphylococcus spp presence was associated with working in the internal medicine ward [OR 6.976 (95% CI 1.767-25.540)] and the surgical ward [OR 5.795 (95% CI 1.586-21.178)]. Staphylococcus spp was more prevalent in males vs. females (81.3% vs. 54.9%, p=0.008) and in medical vs. nursing personnel (76.9% vs. 54.8, p=0.019).

In the majority of Gram-negative isolates (56.1%), at least one multi-drug resistant (MDR) or extensively drug resistant (XDR) strain was isolated. A statistically significant higher prevalence of XDR Gram-negative microbes was found on the hands of nursing personnel (22.2% vs. 2.3% for medical doctors, p=0.014). Only 2 methicillin resistant Staphylococcus Aureus (MRSA) out of the 12 Staphylococcus aureus positive samples were identified.

Conclusions: Employees in the ICU are more prone to Gram-negative and not to Gram-positive hand contamination. MDR and XDR pathogens are prevalent, and are associated with nursing profession.

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Screening antibiotics using an Hoechst 33342 dye-accumulation assay to detect efflux activity in Acinetobacter baumannii clinical isolates

Acinetobacter baumannii is a nosocomial pathogen of increasing importance because of its resistance to multiple antibiotics [ 1 ]. Efflux pumps of the resistance-nodulation-division superfamily play a major role in multidrug resistance by actively excreting a very wide range of antimicrobial agents. These efflux pumps are of considerable interest not only because of their role in drug resistance but also because they are targets for novel adjunct therapies [ 2 ]. Recently, research to characterize resistance-modifying efflux pump inhibitors (EPIs) that block

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