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Amphenicols stability in medicated feed – development and validation of liquid chromatography method

Abstract

A liquid chromatography-ultraviolet detection method for the determination of florfenicol (FF) and thiamphenicol (TAP) in feeds is presented. The method comprises the extraction of analytes from the matrix with a mixture of methanol and acetonitrile, drying of the extract, and its dissolution in phosphate buffer. The analysis was performed with a gradient programme of the mobile phase composed of acetonitrile and buffer (pH = 7.3) on a Zorbax Eclipse Plus C18 (150 × 4.6 mm, 5 μm) analytical column with UV (λ = 220 nm) detection. The analytical procedure has been successfully adopted and validated for quantitative determination of florfenicol and thiamphenicol in feed samples. Sensitivity, specificity, linearity, repeatability, and intralaboratory reproducibility were included in the validation. The mean recovery of amphenicols was 93.5% within the working range of 50-4000 mg/kg. Simultaneous determination of chloramphenicol, which is banned in the feed, was also included within the same procedure of FF and TAP stability studies. Storing the medicated feed at room temperature for up to one month decreased concentration in the investigated drugs even by 45%. These findings are relevant to successful provision of therapy to animals.

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Application of FTIR spectroscopy to study the thermal stability of magnesium aspartate-arginine

References [1]. Carstensen, J.T.,1989. Drug Stability. Principles & Practices. Marcel Dekker, New York. [2]. Lin, S-Y., Wang, S-L., 2012. Advances in simultaneous DSC-FTIR microspectroscopy for rapid solid-state chemical stability studies: Some dipeptide drugs as examples. Advanced Drug Delivery Reviews. 64, 461-478. [3]. Marcoin, W., Pasterny, K.,, Wrzalik, R., 2005. Quantum-mechanical calculations of magnesium aspartate-arginine structure and spectroscopic characteristic. Journal of Molecular Structure

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Isothermal and non-isothermal kinetics of hydrolysis of 1-[2-(2- pentyloxyphenylcarbamoyloxy)-(2-methoxymethyl)-ethyl]- perhydroazepinium chloride (BK 129)

. [15] Treindl, L.: Chemical Kinetics (in Slovak). Bratislava: Slovak Pedagogical Publishing House; 1990. [16] Wells, J.I. Drug Stability. In: Pharmaceutical Preformulation Study - The Physicochemical Properties of Drug Substances. Ellis Horwood Ltd. Publisher Chichester; 1988.

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Analysis of Nicotine and Nicotine-Related Compounds in Electronic Cigarette Liquids and Aerosols by Liquid Chromatography-Tandem Mass Spectrometry

Raton, FL, USA, 2016, pp. 925–926. 25. Flora, J.W., C.T. Wilkinson, K.M. Sink, D.L. McKinney, and J.H. Miller: Nicotine-Related Impurities in E-Cigarette Cartridges and Refill E-liquids; J. Liq. Chromatogr. Relat. Technol. 39 (2016) 821–829. DOI: 10.1080/10826076.2016.1266500 26. US Food and Drug Administration (FDA): Guidance for Industry. Drug Stability Guidelines; Available at: https://www.fda.gov/downloads/animalveterinary/guidancecomplianceenforcement/guidanceforindustry/ucm051556.pdf (accessed July 2017) 27. Bertholon, J.F., M.H. Becquemin, I

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Acta Pharmaceutica
The Journal of Croatian Pharmaceutical Society
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