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.L., Sandler, A.D. & Kofinas, P. (2015). Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion. Adv. Mater. 27, 8056–8061. DOI: 10.1002/adma.201503691. 10. Gavasane, A.J. & Pawar, H.A. (2014). Synthetic biodegradable polymers used in controlled drug delivery system: an overview. Clin. Pharmacol. Biopharm. 3(2):121, 1–7. DOI: 10.4172/2167-065X.1000121. 11. Kamaly, N., Yameen, B., Wu, J. & Farokhzad, O.C. (2016). Degradable controlled-release polymers and nanoparticles: mechanisms of controlling drug release. Chem. Rev. 116, 2602–2663. DOI

consisting of electrospun nanofibers, J. Pharm. Sci . 100 (2011) 424–430; https://doi.org/10.1002/jps.22310 11. G. Cheng, X. Ma, J. Li, Y. Cheng, Y. Cao, Z. Wang, X. Shi, Y. Du, H. Deng and Z. Li, Incorporating platelet-rich plasma into coaxial electrospun nanofibers for bone tissue engineering, Int. J. Pharm . 547 (2018) 656–666; https://doi.org/10.1016/j.ijpharm.2018.06.020 12. S. Chou, D. Carson and K. A. Woodrow, Current strategies for sustaining drug release from electrospun nanofibers, J. Control. Rel . 220 , Part B (2015) 584–591; https://doi.org/10

References 1. Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev 2013; 65:104-120 2. Mrsny RJ. Oral drug delivery research in Europe. J Control Release 2012; 161:247-253 3. Webster DM, Sundaram P, Byrne ME. Injectable nanomaterials for drug delivery: carriers, targeting moieties, and therapeutics. Eur J Pharm Biopharm 2013; 84:1-20 4. Ukmar T, Maver U, Planinšek O, Kaučič V, Gaberšček M, Godec A. Understanding controlled drug release from mesoporous silicates: Theory and experiment. Journal

References 1. Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: the past and the future. Adv Drug Deliv Rev 2013; 65:104-120 2. Mrsny RJ. Oral drug delivery research in Europe. J Control Release 2012; 161:247-253 3. Webster DM, Sundaram P, Byrne ME. Injectable nanomaterials for drug delivery: carriers, targeting moieties, and therapeutics. Eur J Pharm Biopharm 2013; 84:1-20 4. Ukmar T, Maver U, Planinšek O, Kaučič V, Gaberšček M, Godec A. Understanding controlled drug release from mesoporous silicates: Theory and experiment. Journal

"design of experiments". Part I: fundamental aspects, Crit. Rev. Ther. Drug Carrier Syst.   22 (2005) 27-105; DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i1.20. United States Pharmacopoeia 27, National Formulary 22, USP Convention, Rockville 2004. B. Singh and S. Singh, A compreshensive computer program for study of drug release kinetics from compressed matrices, Indian J. Pharm. Sci.   60 (1998) 313-316. B. Singh, T. Kaur and S. Singh, Correction of raw dissolution data for loss of drug during sampling, Indian J. Pharm. Sci.   59 (1997) 196-199. R. W. Korsemeyer

containing a soluble drug, J. Control. Release   61 (1999) 83-91; DOI: 10.1016/S0168-3659(99)00104-2. N. A. Peppas, Analysis of Fickian and non-Fickian drug release from polymers, Pharm. Acta Helv.   60 (1985) 110-111.

.   54 (1998) 167-175; DOI: 10.1016/s0168-3659(97)00113-2. P.Y. Wang, C.X. Song, H.F. Sun, H.L. Shi and R.W. Shi, A biodegradable long-term contraceptive implant, Eng. Med. Biol. Soc.   6 (1998) 2901-2904; DOI: 10.1109/IEMS.1998.746093. http://www.surgistrategies.com/hotnews/baxter-agreement-with-innocall-implant.html C. Guse, S. Koennings, F. Kreye, F. Siepmann, A. Goepferich and J. Siepmann, Drug release from lipid-based implants: Elucidation of the underlying mass transport mechanisms, Int. J. Pharm.   314 (2006) 137-144; DOI: 10.1016/j.i.jpharm.2005.08.030. J

ABSTRACT

The binding properties of Eucalyptus gum obtained from the incised trunk of Eucalyptus tereticornis, were evaluated in paracetamol tablet formulations, in comparison with that of Gelatin B.P. In so doing, the compression properties were analyzed using density measurements and the compression equations of Heckel, Kawakita and Gurham. In our work, the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while the drug release properties of the tablets were assessed using disintegration and dissolution times. The results of the study reveal that tablet formulations incorporating Eucalyptus gum as binder, exhibited faster onset and higher amount of plastic deformation during compression than those containing gelatin. What is more, the Gurnham equation could be used as a substitute for the Kawakita equation in describing the compression properties of pharmaceutical tablets. Furthermore, the crushing strength, disintegration and dissolution times of the tablets increased with binder concentration, while friability values decreased. We noted that no significant differences in properties exist between formulations derived from the two binders (p > 0.05) exist. While tablets incorporating gelatin exhibited higher values for mechanical properties, Eucalyptus gum tablets had better balance between mechanical and release properties - as seen from the CSFR/Dt values. Tablets of good mechanical and release properties were prepared using Eucalyptus gum as a binder, and, therefore, it could serve as an alternative binder in producing tablets with good mechanical strength and fast drug release.

dissolution profiles, Eur. J. Pharm. Sci. 13 (2001) 123–133; https://doi.org/10.1016/S0928-0987(01)00095-1 22. S. Dash, P. N. Murthy, L. Nath and P. Chowdhury, Kinetic modeling on drug release from controlled drug delivery systems, Acta Pol. Pharm . 67 (2010) 217–223; https://doi.org/10.1080/10717540490265379 23. V. A. Belousov, Choice of optimal pressure values in tabletting medicinal powders, Khim. Farm. Zh . 10 (1976) 105–111. 24. Y. Lei, Q. Zhou, Y. Zhang, J. Chen, S. Sun and I. Noda, Analysis of crystallized lactose in milk powder by Fourier

Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration

The objective of the investigation was to study the effect of bromhexine hydrochloride (BXH) content and agglomerate size on mechanical, compressional and drug release properties of agglomerates prepared by crystallo-co-agglomeration (CCA). Studies on optimized batches of agglomerates (BXT1 and BXT2) prepared by CCA have showed adequate sphericity and strength required for efficient tabletting. Trend of strength reduction with a decrease in the size of agglomerates was noted for both batches, irrespective of drug loading. However, an increase in mean yield pressure (14.189 to 19.481) with an increase in size was observed for BXT2 having BXH-talc (1:15.7). Surprisingly, improvement in tensile strength was demonstrated by compacts prepared from BXT2, due to high BXH load, whereas BXT1, having a low amount of BXH (BXH-talc, 1:24), showed low tensile strength. Consequently, increased tensile strength was reflected in extended drug release from BXT2 compacts (Higuchi model, R2 = 0.9506 to 0.9981). Thus, it can be concluded that interparticulate bridges formed by BXH and agglomerate size affect their mechanical, compressional and drug release properties.