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Deep brain stimulation in the obsessive-compulsive syndrome

Abstract

Introduction The authors present an overview of current views on the treatment of obsessive-compulsive disorder refractory to pharmacological and psychological treatment.

Aim: To review the mechanisms of stimulation of deep brain structures and to evaluate the effectiveness of therapy in obsessive-compulsive disorder.

Method: Review and analysis of the Polish and foreign scientific articles from the years 1999-2016.

Conclusions: According to the literature considered, in half of the examined patients there was an improvement of over 35% on the Y-BOCS scale, in some patients even a reduction of symptoms reaching 81-83% was described. Previous studies have been carried out on small groups of patients. Since 2009, the method of invasive treatment with deep brain stimulation of the obsessive-compulsive syndrome is registered in the EU. In spite of the above, additional studies are necessary on a larger group of patients in order to precisely estimate the effectiveness of the procedure and elaborate the criteria for qualifying patients for inclusion in the procedure.

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Impedance detection of the electrical resistivity of the wound tissue around deep brain stimulation electrodes permits registration of the encapsulation process in a rat model

Introduction Neuromodulation is among the fastest growing areas in medicine. It involves cortical and sub-cortical electrical stimulation for the treatment of an increasing number of neurological and psychiatric diseases. Among interventions that use electrical stimulation to treat movement disorders, such as Parkinson’s disease (PD), deep brain stimulation (DBS) is probably the most successful approach [ 1 ]. High-frequency (approx. 130 Hz, 60-μs needle pulses) DBS of the subthalamic nucleus (STN) is an effective therapeutic option for PD patients

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