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assessment of coronary artery disease by cardiac computed tomography. Korean Circ J . 2013;43(7):435-442. 27. Zarins CK, Taylor CA, Min JK. Computed fractional flow reserve (FFRCT) derivated from coronary CT angiography. J Cardiovasc Transl Res . 2013;6(5):708-714. 28. Taylor CA, Fonte TA, Min JK. Computational Fluid Dynamics Applied to Cardiac Computed Tomography for Noninvasive Quantification of Fractional Flow Reserve. J Am Coll Cardiol . 2013;61(22):2233-2241. 29. Koo BK, Erglis A, Doh JH, et al. Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive

REFERENCES 1. ABED Y, JAMEE A. Characteristics and risk factors attributed to coronary artery disease in women attended health services in Gaza-Palestine observational study . World J Cardiovasc Dis. 2015; 5 (01):9. 2. ROGER VL, GO AS, LLOYD-JONES DM, BENJAMIN EJ, BERRY JD, BORDEN WB, et al. Executive summary: heart disease and stroke statistics--2012 update: a report from the American Heart Association . Circulation. 2012; 125 (1):188-97. 3. MOSHAR S, NAJIBPOUR R, MOHSENIKIA M, BAYESH S, RAD KV, RAHIMI N. Comparison of angiography findings in iranian

Nutrition. 2003; 22:258-68. 5. Upston JM, Terentis AC, Stocker R. Tocopherolmediated peroxidation of lipoproteins: implications for vitamin E as a potential anti-atherogenic supplement. The FASEB Journal. 1999; 13:977-94. 6. Regnstrom J, Nilsson J, Moldeus P, Strom K, Bavenholm P, Tornvall P , Hamsten A. Inverse relation between the concentration of low-density-lipoprotein vitamin E and severity of coronary artery disease. Am J Clin Nutr. 1996; 63:377-85. 7. Gey KF, Pushka P, Jordan P, Moser UK. Inverse correlation between plasma vitamin E and mortality from ischemic

Study Group. The BEAUTIFUL study: Randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction—baseline characteristics of the study population. Cardiology , 110 , 271-282. Balode, I., Jēgere, S., Mintāle, I., Narbute, I., Zakke, I., Latkovskis, G., Ērglis, A. (2010). Current state of angina treatment in the outpatient population and heart rate monitoring survey in Latvia (REALITY Latvia). Proc. Latv. Acad. Sci., Section B , 64 (5/6), 194-201. Boden, W.E., O'Rouke, R., Teo, K.T., Hartigan, P.M., Maron, D

-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther 2013;27:37-48. [17] Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res 2012;32:537-41.

-reactive protein: clinical importance. Curr. Probl. Cardiol 2004;29:439-493. 12. Tomai F, Ribichini F, Ghini A, et al. Elevated C-reactive protein levels and coronary microvascular dysfunction in patients with coronary artery disease. European Heart Journal 2005;26:2099-2105. 13. Libby P, Crea F. Clinical implications of inflammation for cardiovascular primary prevention. European Heart Journal 2010;31:777-783. 14. Gencer B, Auer R, Rekeneire N, et al. Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition

References Komorovsky R, Desideri A. Carotid Ultrasound Assessment of Patients with Coronary Artery Disease: A Useful Index for Risk Stratification. Vasc Health Risk Manag. 2005;1(2):131-136. doi:10.2147/vhrm.1.2.131.64077 PMID:17315399 PMCID:1993944 Abdou E, Bax JJ, et al. Dobutamine Stress Myocardial Perfusion Imaging in Coronary Artery Disease. J Nuclear Med. 2002;43(12):1634-1646. Honda O, Sugiyama S, Kugiyama K et al. Echolucent carotid plaques predict future coronary events in patients with coronary artery disease. J Am Coll Cardiol. 2004

Introduction Coronary artery disease (CAD), especially acute myocardial infarction, is becoming one of the major causes of morbidity and mortality worldwide [ 1 ]. Multiple factors, such as genetic variants, lifestyle and environmental factors, are believed to be involved in the occurrence and progression of CAD [ 2 , 3 , 4 ]. In recent years, more and more researchers carry out large scale genomewide association studies (GWAS) to elucidate the pathogenesis of CAD at the gene expression level and the results have demonstrated that gene polymorphisms are

. Am J Med . 1969;46:428-440. 15. Gaasch W, Zile M. Left Ventricular Diastolic Dysfunction and Diastolic Heart Failure. Annual Review of Medicine . 2004;55:373-394. 16. Allman K, Shaw L, Hachamovitch R, Udelson J. Myocardial Viability Testing and Impact of Revascularization on Prognosis in Patients With Coronary Artery Disease and Left Ventricular Dysfunction: A Meta-Analysis. J Am Coll Cardiol . 2002;39:1151-1158. 17. Beller GA. Noninvasive assessment of myocardial viability. N Engl J Med . 2000;343:1488-1490. 18. Bulkley BH, Ridolfi RL, Salyer WR, et al

References Bosevski M, Meskovska S, Tosev S, Peovska I, Asikov I, Georgievska-Ismail LJ. Risk factors for development of critical limb ischemia — a survey of diabetic vs. nondiabetic population. Prilozi. 2006;27(2):89-96. PMID:17211294 Bosevski M, Borozanov V, Georgievska-Ismail L. Influence of metabolic risk factors on the presence of carotid artery disease in patients with type 2 diabetes and coronary artery disease. Diab Vasc Dis Res. 2007;4(1):49-52. doi:10.3132/dvdr.2007.006 PMID:17469044 Bosevski M, Borozanov V, Gucev F, Bosevska G, Tosev S, Georgievska