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Abstract

Introduction: Autologous hematopoietic stem cell transplantation (ASCT) represents a standard therapy in the management of hematologic malignancies such as malignant lymphomas and has used for approximately three decades. The aim of this study was to determine the occurring post-ASCT complications and their impact on the patients’ recovery for a better management.

Material and methods: An observational retrospective study was performed during a five-year period between 2012 and 2017, involving 58 classical Hodgkin lymphoma and 36 non-Hodgkin lymphoma patients, who underwent ASCT in the Bone Marrow Transplantation Unit of Tîrgu Mureş. The main analyzed complications were: infections, bleeding, hydroelectrolytic disorders, and hypoalbuminemia.

Results: After data analysis we found that 17 patients (18%) presented microbiologically confirmed infection, 10 patients (11%) presented clinically non-significant bleeding, 39 patients (42%) presented electrolyte disorders, and 33 patients (36%) presented hypoalbuminemia, obtaining a positive correlation between the rate of adverse events after ASCT with age (r = 0.9914, p = 0.0009) and the average hospitalization period (r = 1, p <0.00001).

Conclusions: The identification of adverse events and their correlation with the patients’ clinical outcome can lead to better patient management and a faster recovery after ASCT.

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City in 2016 amounted to 99.58%, K4 was 96.29% and treatment of obstetric complications was 2,582 (70.01%) from 3,688 estimates of pregnant women with complications. Of the 22 Public Healths in Padang City, there were 3 health centers with K1 and K4 coverage which were still lower than the targets of K1 (100%) and K4 (95%) coverage, namely Air Tawar Health Center, Lubuk Buaya and Seberang Padang. Sequentially for K1 coverage of 94.61%, 92.42%, 93.97% and K4 coverage of 87.75%, 87.89%, 93.42%. The lowest coverage of obstetric complications management is