Poland’s accession to the European Union has given many opportunities both in terms of access to the EU economy and European funds. Owing to the set sustainable development goals, the business sphere faces the challenge of their implementation through, among others, activities in the area of social and human capital, and environmental protection. It is important to model solutions that enable sustainable production and consumption. The introduction of innovative product and process technologies may contribute to increasing the competitiveness of SMEs in the Textile and Clothing sector, which in consequence should also contribute to the implementation of objectives of the Regional Smart Specializations for Lodz Province. An example of such solutions is the system for personalized production of clothes presented in the article. The aim of the article is to determine the current situation of the Polish clothing industry in trade with the European Union by analyzing comparative advantages for CN 61 and 62 (related to the clothing industry) and presenting the level of innovation of Lodz Province against the background of Poland as a region specializing in the production of clothing under the adopted Regional Smart Specializations for Lodz Province. It is assumed that the presented system for the personalized production of clothing may affect the competitiveness of this industry and the region.