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Acute Lymphoblastic Leukemia after previously treated, relapsed Chronic Lymphocytic Leukemia: A Case Report

REFERENCES 1. DIEHL LF, KARNELL LH, MENCK HR. The National Cancer Data Base report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia . Cancer 1999; 86 :2684–2692. 2. SGAMBATI MT, LINET MS, DEVESA SS. Chronic lymphocytic leukemia: epidemiological, familial, and genetic aspects. In: Cheson BD, ed. Chronic lymphoid leukemias, 2 nd ed. New York: Marcel Dekker, 2001:33–62. 3. ZENT CS, KYASA MJ, EVANS R, et al . Chronic lymphocytic leukemia incidence is substantially higher than estimated from tumor registry

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Watch and Wait – Actualities in the Treatment of Chronic Lymphocytic Leukemia

REFERENCES 1. SEER Cancer Statistics Review (CSR), 1975-2011. Available at: seer.cancer.gov/csr/1975_2011/ 2. Scarfò L, Ferreri AJM, Ghia P. Chronic lymphocytic leukaemia. Crit Rev Oncol Hematol . 2016;104:169-182. 3. Hallek M, Pflug N. Chronic lymphocytic leukemia. Annals of Oncology . 2010;21:vii154–vii164. 4. Hallek M. Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. Am J Hematol . 2015;90:446-460. 5. Hallek M. Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification

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The Diagnostic Value of Flow Cytometry Imunophenotyping in an Albanian Patient Population with a Preliminary Clinical Diagnosis of Chronic Lymphocytic Leukemia

References 1. Rawstron AC, Bennett FL, Connor SJM, Kwok M, Fenoton JAL, Plummer M, De Tute R, Owen RG, Richards SJ, Jack AS, Hillmen P. Monoclonal B-cell lymphocytosis and chronic lymphocitic Leukemia. N Engl J Med. 2008; 359:575-83. 2. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med. 2005; 352: 804-15. 3. Gribben JG. Molecular profiling in CLL. Hematology Am Soc Hematol Educ Program. 2008:444-9. 4. Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S

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Evaluation of the prognostic and predictive value of free light chains in patients with chronic lymphocytic leukemia – preliminary results

CJ, et al. Chronic lymphocytic leukaemia. Nat Rev Dis Primers 2017;3:16096. 10.1038/nrdp.2016.96 Kipps TJ Stevenson FK Wu CJ et al Chronic lymphocytic leukaemia Nat Rev Dis Primers 2017 3 16096 [2] Podhorecka M, Macheta A, Bozko M, et al. Deregulation of apoptosis – Is it still an important issue in pathogenesis of chronic lymphocytic leukemia? Curr Cancer Drug Targets 2016;16:652–8. 10.2174/1568009616666160427103930 Podhorecka M Macheta A Bozko M et al Deregulation of apoptosis – Is it still an important issue in pathogenesis of

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Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia

biology and prognosis. Hematology Am Soc Hematol Educ Program 2005: 278–84. 2. Chiorazzi N. Implications of new prognostic markers in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program; 2012: 76–87. 3. Sagatys EM, Zhang L. Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia. Cancer Control 2012; 19(1): 18–25. 4. Lekovic D, Mihaljevic B, Kraguljac-Kurtovic N, Peruncic-Jovanovic M, Bogdanovic A, Colovic M, et al. Prognostic significance of new biological markers in chronic lymphocytic leukaemia. Srp Arh Celok

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Platinum Complexes And Their Anti-Tumour Activity Against Chronic Lymphocytic Leukaemia Cells

, Dighiero G, Döhner H, Hallek M, Hillmen P, Keating M, Montserrat E, Kipps TJ & Rai K. (2006). Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Blood. 107(3), 859-861. 10. Chastain EC & Duncavage EJ. (2015). Clinical Prognostic Biomarkers in Chronic Lymphocytic Leukemia and Diffuse Large B-Cell Lymphoma. Arch Pathol Lab Med. 139(5), 602-607. 11. Caligaris-Cappio F. (2009). Chronic lymphocytic leukemia: “Cinderella” is becoming a star. Mol Med. 15(3-4), 67-69. 12. Rai KR, Sawitsky A, Cronkite EP, Chanana AD

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Recent Advances in the Pathogenesis and Treatment of Chronic Lymphocytic Leukemia

lymphocytic leukaemia is driven by antigen-indepen-dent cell-autonomous signalling. Nature. 2012; 489(7415): 309.12. 46. Binder M, Muller F, Frick M, Wehr C, Simon F, Leistler B, et al. CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL. Blood. 2013; 121(1): 239.41. 47. Lanemo Myhrinder A, Hellqvist E, Sidorova E, et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood. 2008; 111(7): 3838.3848. 48

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in PRILOZI
Prognostic value of immunohistochemical expression of ZAP-70 and CD38 in chronic lymphocytic leukaemia detected on bone marrow and lymph node biopsies / Valoarea prognostică a expresiei imunohistochimice a ZAP-70 si CD38 în leucemia limfocitară cronică detectată pe biopsii osteomedulare și limfoganglionare

(13):4609-14. DOI: 10.1182/blood-2002-06-1683 13. Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, et al. ZAP-70 expression as a surrogate for immunoglobulin variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003; 348(18):1764-75. DOI:10.1056/NEJMoa023143 14. Orchard JA, Ibbotson RE, Davis Z, Wiestner A, Rosenwald A, Thomas PW, et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet. 2004 Jan 10;363(9403):105-11. DOI: 10.1016/S0140-6736(03)15260-9 15. Rassenti LZ, Huynh

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The expression BIRC6 gene in patients with chronic lymphocytic leukemia – a preliminary study

ABSTRACT

The BIRC6 gene encodes the Bruce (Apollon) protein. This belongs to the III class of Inhibitors of the Apoptosis Protein (IAP) and demonstrates anti-apoptotic activity (binding, inhibiting and degrading the caspases). Moreover, the Bruce protein shows multilevel activities and additional functions. The Bruce protein is involved in the maintenance of cell viability, and it is also suggested that it plays an important role in cell proliferation and diversification. Many researchers have noticed elevated BIRC6 gene expression in cell lines of brain cancer and ovarian carcinoma, leukemia, breast cancer and even in colorectal cancer tissues. Resistance to chemotherapy-inducted apoptosis in cancers characterized by BIRC6 gene over-expression was also reported. The aim of the study was to assess the BIRC6 gene expression in peripheral blood lymphocytes of patients diagnosed with chronic lymphocytic leukemia.

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Expression Of The Bcl2 Gene In Chronic Lymphocytic Leukaemia Patients

ABBREVIATIONS Bcl2 - B-cell lymphoma 2 CLL - Chronic lymphocytic leukaemia mRNA – messenger ribonucleic acid miRNA - micro ribonucleic acid qRT-PCR - quantitative reverse-transcriptase polymerase chain reaction REFERENCES 1. Sagatys EM, Zhang L. Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia. Cancer Control 2012;19(1):18-25. 2. Chiorazzi N. Implications of new prognostic markers in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2012;2012:76-87. 3. Obermann EC, Went P

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