Magdalena Rojewska, Małgorzata Popis, Maurycy Jankowski, Dorota Bukowska, Paweł Antosik and Bartosz Kempisty
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Sylwia Borys-Wójcik, Małgorzata Józkowiak, Katarzyna Stefańska, Sandra Knap, Wojciech Pieńkowski, Paweł Gutaj, Małgorzata Bruska and Bartosz Kempisty
1. Olszewska-Słonina DM, Drewa TA. Cell culture, tissue engineering and regenerative medicine. Part I. Wiadomosci Lek Wars Pol. 1960;59:585–9.
2. Gest H. The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world. Perspect Biol Med. 2005;48:266–72; DOI:10.1353/pbm.2005.0053.
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Mikołaj Lorenz, Paul Mozdziak, Bartosz Kempisty and Marta Dyszkiewicz-Konwińska
Arguably, the stem cell revolution began with the isolation of the first embryonic stem cell lines by Sir Martin Evans (Evans and Kaufman, 1981) with the initial application to generate functional gene knockouts, which lead to significant scientific discovery [ 1 ].
The application of stem cells is one of the subjects most studied in recent years related to treating various diseases. The possibility of implementing stem cells in Parkinson’s disease, amyotrophic lateral sclerosis, spinal cord injury or stroke could revolutionize current nervous
Sylwia Borys-Wójcik, Lisa Moncrieff, Bartosz Kempisty and Marta Dyszkiewicz-Konwińska
) enveloped in connective tissue called Wharton’s jelly (WJ) and covered by epithelium [ 1 ].
In recent years, the research at preclinical and clinical levels on stem cells derived from the umbilical cord is conditioned by these cells self-renewal ability, high potential for differentiation, immuno-modulatory properties, as well as their ability to restore tissues [ 2 ].
In this article, we try to present the latest reports on the use of umbilical cord stem cells in the treatment of common autoimmune diseases,such as type I diabetes or multiple sclerosis,and also the
Lisa Moncrieff, Paul Mozdziak, Michal Jeseta, Marie Machatkova, Wiesława Kranc and Bartosz Kempisty
Granulosa cells (GCs), otherwise known as ovarian follicular cells, are the largest component of follicular fluid [ 1 ]. Alongside GCs are theca cells, ovarian surface epithelial (OSE) cells, and oocytes. Together, the Graafian follicle will form to protect the oocyte (folliculogenesis) and germ cells also mature into an egg (oogenesis) [ 2 , 3 ]. Granulosa cells have small cell-secreted vesicles called exosomes which are essential in mediating communication between cells, and they share this role with gap junctions [ 4 ]. Exosomes secrete small
Claudia Dompe, Grzegorz Wąsiatycz, Paul Mozdziak, Maurycy Jankowski and Bartosz Kempisty
The ability of stem cells to differentiate towards different cell lineages and constantly self-renew-makes them a promising tool in cell-based therapies such as tissue engineering and regenerative medicine [ 1 ]. The potential clinical application of stem cells remains highly significant and still not reduced to practice. Adipose derived stem cells (ADSCs) were firstly characterized in 2001, with first description of the adipose tissue as an effective source of mesenchymal progenitors.
ADSCs have similar characteristics as mesenchymal stem
Katarzyna Stefańska, Ievgenia Kocherova, Sandra Knap, Magdalena Kulus, Piotr Celichowski and Michal Jeseta
The female reproductive tract is composed of the oviduct, uterus, cervix and vagina. The oviduct derives from the Müllerian duct and plays vital role in successful monospermic fertilization and female fertility. It has two muscle layers and a mucous lining and is covered with two types of epithelial cells: ciliated and non-ciliated secretory. The oviduct consists of four regions: the infundibulum, the ampulla, which is the site of fertilization, the isthmus and the uterotubal junction. It is involved in sperm guidance to fertilization site via
Maurycy Jankowski, Marta Dyszkiewicz-Konwińska, Joanna Budna, Yan Huang, Sandra Knap, Artur Bryja, Sylwia Borys, Wiesława Kranc, Michal Jeseta, Magdalena Magas, Dorota Bukowska, Paweł Antosik, Klaus P. Brüssow, Marie Machatkova, Małgorzata Bruska, Michał Nowicki, Maciej Zabel and Bartosz Kempisty
Serial Analysis of Gene Expression,” Cancer Epidemiol. Prev. Biomarkers , vol. 14, no. 7, 2005.
4. Budna, J. et al. , “Does Porcine Oocytes Maturation in Vitro is Regulated by Genes Involved in Transforming Growth Factor Beta Receptor Signaling Pathway?,” Adv. Cell Biol. , vol. 5, no. 1, pp. 1-14, Jan. 2017.
5. Bukovský, A., Keenan, J. A., Caudle, M. R., Wimalasena, J., Upadhyaya, N. B., and Van Meter, S. E., “Immunohistochemical studies of the adult human ovary: possible contribution of immune and epithelial factors to folliculogenesis.,” Am. J. Reprod