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Stemness specificity of epithelial cells – application of cell and tissue technology in regenerative medicine

References 1. van Bekkum DW. Stem cell transplantation in experimental models of autoimmune disease. J Clin Immunol. 2000;20(1):10–6. 2. Angelini A, Castellani C, Ravara B, Franzin C, Pozzobon M, Tavano R, Libera LD, Papini E, Vettor R, Coppi P de, Thiene G, Vescovo G. Stem-cell therapy in an experimental model of pulmonary hypertension and right heart failure: role of paracrine and neurohormonal milieu in the remodeling process. J Heart Lung Transplant. 2011;30(11):1281–93; DOI:10.1016/j.healun.2011.07.017. 3. Elsaadany B, El Kholy S, El Rouby

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The use of mesenchymal stem cells in veterinary medicine

References 1. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145-1147; DOI:10.1126/SCIENCE.282.5391.1145. 2. Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep. 2015;35(2); DOI:10.1042/BSR20150025. 3. Fortier LA, Nixon AJ, Williams J, Cable CS. Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. Am J Vet Res. 1998

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Stem Cells of Adult Organisms in Biology and Medicine

References [1] AASEN T, RAYA A, BARRARO MJ et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnol 2008; 26: 1276-1284. [2] ALBERTS B, BRAY D, HOPKIN K et al. Essential Cell Biology, 2005 PWN. [3] AL-HAJJ M, CLARKE MF. Self-renewal and solid tumor stem cells. Oncogene 2004; 23: 7274-7282. [4] ALLAN DS, KEENEY M, HOWSON-JAN K et al. Number of viable CD34+ cells reinfused predicts engrafment in autologous hemopoietic stem cell

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Historical background of umbilical stem cell culture

References 1. Olszewska-Słonina DM, Drewa TA. Cell culture, tissue engineering and regenerative medicine. Part I. Wiadomosci Lek Wars Pol. 1960;59:585–9. 2. Gest H. The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world. Perspect Biol Med. 2005;48:266–72; DOI:10.1353/pbm.2005.0053. 3. Vasil IK. A history of plant biotechnology: from the Cell Theory of Schleiden and Schwann to biotech crops. Plant Cell Rep. 2008;27:1423–40; DOI:10.1007/s00299-008-0571-4. 4. Sonig A, Gandhi V, Nanda A. From the cell of

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Application potential and plasticity of human stem cells

Introduction Arguably, the stem cell revolution began with the isolation of the first embryonic stem cell lines by Sir Martin Evans (Evans and Kaufman, 1981) with the initial application to generate functional gene knockouts, which lead to significant scientific discovery [ 1 ]. The application of stem cells is one of the subjects most studied in recent years related to treating various diseases. The possibility of implementing stem cells in Parkinson’s disease, amyotrophic lateral sclerosis, spinal cord injury or stroke could revolutionize current nervous

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Current state of umbilical cord stem cells in humans

) enveloped in connective tissue called Wharton’s jelly (WJ) and covered by epithelium [ 1 ]. In recent years, the research at preclinical and clinical levels on stem cells derived from the umbilical cord is conditioned by these cells self-renewal ability, high potential for differentiation, immuno-modulatory properties, as well as their ability to restore tissues [ 2 ]. In this article, we try to present the latest reports on the use of umbilical cord stem cells in the treatment of common autoimmune diseases,such as type I diabetes or multiple sclerosis,and also the

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Ovarian follicular cells - living in the shadow of stemness cellular competence

Introduction Granulosa cells (GCs), otherwise known as ovarian follicular cells, are the largest component of follicular fluid [ 1 ]. Alongside GCs are theca cells, ovarian surface epithelial (OSE) cells, and oocytes. Together, the Graafian follicle will form to protect the oocyte (folliculogenesis) and germ cells also mature into an egg (oogenesis) [ 2 , 3 ]. Granulosa cells have small cell-secreted vesicles called exosomes which are essential in mediating communication between cells, and they share this role with gap junctions [ 4 ]. Exosomes secrete small

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Current clinical applications of adipose-derived stem cells in humans and animals

Introduction The ability of stem cells to differentiate towards different cell lineages and constantly self-renew-makes them a promising tool in cell-based therapies such as tissue engineering and regenerative medicine [ 1 ]. The potential clinical application of stem cells remains highly significant and still not reduced to practice. Adipose derived stem cells (ADSCs) were firstly characterized in 2001, with first description of the adipose tissue as an effective source of mesenchymal progenitors. ADSCs have similar characteristics as mesenchymal stem

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The genes regulating maintenance of cellular protein location are differentially expressed in porcine epithelial oviductal cells during longterm in vitro cultivation

Introduction The female reproductive tract is composed of the oviduct, uterus, cervix and vagina. The oviduct derives from the Müllerian duct and plays vital role in successful monospermic fertilization and female fertility. It has two muscle layers and a mucous lining and is covered with two types of epithelial cells: ciliated and non-ciliated secretory. The oviduct consists of four regions: the infundibulum, the ampulla, which is the site of fertilization, the isthmus and the uterotubal junction. It is involved in sperm guidance to fertilization site via

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Does migrative and proliferative capability of epithelial cells reflect cellular developmental competence?

Serial Analysis of Gene Expression,” Cancer Epidemiol. Prev. Biomarkers , vol. 14, no. 7, 2005. 4. Budna, J. et al. , “Does Porcine Oocytes Maturation in Vitro is Regulated by Genes Involved in Transforming Growth Factor Beta Receptor Signaling Pathway?,” Adv. Cell Biol. , vol. 5, no. 1, pp. 1-14, Jan. 2017. 5. Bukovský, A., Keenan, J. A., Caudle, M. R., Wimalasena, J., Upadhyaya, N. B., and Van Meter, S. E., “Immunohistochemical studies of the adult human ovary: possible contribution of immune and epithelial factors to folliculogenesis.,” Am. J. Reprod

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