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References 1. Mederos R, Danielpour P, Christopher M, Middendorf BA, Willis I, Minervini D, Vicentelli C. Goblet cell carcinoid tumors of the appendix: Report of two cases and a short review of the literature. Surgery Journal. 2007; 2:33-6. 2. Haggani MT, Williams G. Mucin producing carcinoid tumours of the vermiform appendix. J Clin Pathol. 1997;30:473-80. 3. Roy P, Chetty R. Goblet cell carcinoid tumors of the appendix: An overview. World J Gastrointest Oncol. 2010;2:251-8. 4. Özdamar ŞO, Barut F, Kertiş G, Bahadır B, Emre AU, Gün B. Appendiks vermiformis

and carcinoid tumors. Biogenic amines 1989; 6 : 247-52. Feldmam JM. Carcinoid Tumors. In: Massaferi EL et al. Endocrine tumors. Boston: Blackwell , 1993; 700-22. Huttner WB, Gerdes HH, Rosa P. The granin (chromogranin/secretogranin) family. Trends Biochem Sci 1991; 16 : 27-30. Winkler H, Fischer-Colbrie R. The chromogranins A and B; the firs 25 years, and future perspectives. Neuroscience 1992; 49 : 497-528. Fischer-Cilbrie R, Frischenschlager T. Immunological characterization of secretory proteins of chromaffin granules: Chromogranin A, chromogranin B

REFERENCES 1. Bosman F.T., Carneiro, R., Hruban H., Theise N.D., editors (2010), WHO Classification of Tumours of the Digestive System 4 th ed., Lyon: The International Agency for Research on Cancer. 2. Cai Y.C. et al.: Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. Hum.Pathol ., 32, 10, 2001. 3. Erim T., Colak Y., Szomstein S.: Gastric carcinoid tumor after laparoscopic sleeve gastrectomy., Surgery for Obesity and Related Diseases, Volume 11, Issue 6

References Rindi G, Villanacci V, Ubiali A, Scarpa A. Endocrine tumors of the digestive tract and pancreas: histogenesis, diagnosis and molecular basis. Expert Rev Mol Diagn 2001; 1: 323-33. Solcia E, Rindi G, Paolotti D, et al. Clinicopathological profile as a basis for classification of the endocrine tumours of the gastroenteropancreatic tract. Ann Oncol 1999; 10 (Suppl 2): S9-S15. Oberg K. Carcinoid tumors: molecular genetics, tumor biology, and update of diagnosis and treatment. Curr Opin Oncol 2002; 14: 38-45. Lamberts SW, Hofland LJ, Nobels FR

References 1. Barakat MT, Meeran L, Bloom SR. Neuroendocrine tumors. Endocr Relat Cancer. 2004 Mar;11(1):1-18. DOI: 10.1677/erc.0.0110001 2. Oberndorfer S. Karzinoide tumoren des dunndarms. Frank Z Pathol. 1907;1:426-432. 3. Salazar R, Wiedenmann B, Rindi G, Ruszniewski P. ENETS 2011 Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors: An Update. Neuroendocrinology. 2012;95(2):71-3. DOI: 10.1159/000335600 4. Pinchot S, Holen K, Sippel R, Chen H. Carcinoid Tumors. Oncologist. 2008;13(12):1255-1269. DOI: 10.1634/theoncologist

. Vetorazzo Filho JE, Bahia LA, Esteves PE et al. - Renal hemangiopericytoma: case report and literature review.Einstein (Sao Paulo). 2015;13(2):269-72. 24. Gu X, Cheng M, Herrera GA -Kidney carcinoid tumor: Histological, immunohistochemical and ultrastructural features.Ultrastruct Pathol. 2018;42(1):18-22.

Introduction Among patients with neuroendocrine tumours (NET) hepatic metastases are present in 46%–93% at initial presentation. 1 , 2 The metastases may be responsible for hormone-related symptoms, including carcinoid syndrome and uncontrollable hypoglycemia in case of insulinoma. These clinical symptoms can be treated effectively with somatostatin analogues in more than 70% of patients, but efficacy can decrease with time. 3 Although surgical resection of NET liver metastases can be curative and remains the treatment of choice, only 10% of patients are

of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE). Ann Oncol. 2010;21(9):1794-803. 4. Quaedvlieg P, Visser O, Lamers C, Heijen M, Taal B. Epidemiology and survival in patients with carcinoid disease in the Netherlands. An epidemiological study with 2,391 patients. Ann Oncol. 2001;12:1295-300. 5. Boxberger N, Redlich A, Boger Ch, Leuschner I, Schweinitz D, Vorwerk H. Neuroendocrine tumors of the appendix in children and adolescents. Pediatr Blood Cancer. 2013;60:65- 70. 6. Goede A, Caplin M

al. Horseshoe kidney is associated with an increased relative risk of primary renal carcinoid tumor. J Urol. 1997;157:205-2066. 6. Rodríguez-Covarrubias F, Gómez X, Valerio JC, Lome-Maldonado C, Gabilondo F. Carcinoid tumor arising in a horseshoe kidney. Int Urol Nephrol. 2007;39(2):373-376.

REFERENCES 1. LI TT, QIU F, QIAN ZR, WAN J, QI XK, WU BY. Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors . World J Gastroenterol. 2014; 20 (1): 118-25. 2. MODLIN IM, LYE KD, KIDD M. A 5-decade analysis of 13,715 carcinoid tumors . Cancer. 2003; 97 :934-59. 3. HIRAI M, MATSUMOTO K, UEYAMA H, FUKUSHIMA H, MURAKAMI T, et al. A case of neuroendocrine tumor G1 with unique histopathological growth progress . World J Gastrointest Endosc. 2013; 5 (12): 605-9. 4. KULKE MH, SHAH MH, BENSON AB, BERGSLAND E, BERLIN JD, et