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, Rubens RD. The biology and management of bone metastases. Crit. Rev. Oncol. Hematol. 1999; 31:89–96. 8. Roodman GD. Mechanisms of bone metastasis. N. Engl. J. Med. 2004; 350:1655–1664. 9. Hage WD, Aboulafia AJ, Aboulafia DM. Incidence, location, and diagnostic evaluation of metastatic bone disease. Orthop. Clin. N. Am. 2000; 31:515–528. 10. Blum R.H., Novetsky D., Shasha D., Fleishman S. The multidisciplinary approach to bone metastases. Oncology. 2003;17:845–857; discussion 862–863, 867. 11. Moriwaki S. Histopathology and statistical analysis of spinal metastases of

48 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 MULTIDISCIPLINARY APPROACH IN THE TREATMENT OF MALIGNANT BONE TUMORS doi: 10.2478/rojost-2018-0059 L. Marinca1,2, D. Pop1,2, O. Moraru3, I.C. Stoica1,2 1”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2“Foişor” Clinical Orthopaedic Hospital, Bucharest, Romania 3”Agrippa Ionescu” Military Hospital, Bucharest, Romania Introduction. There are two types of tumor lesions at bone level: primary tumors and bone metastasis. These lesions cause a

cells in metastatic sites. Nature. 2 August 2002; 563-672. 5. Liang H, Wang XN, Wang BG et al. Prognostic factors of young patients with colon cancer after surgery. World J Gastroenterol. 2006; 12:1458-62. 6. Ihle PM, McBeath AA. Bone metastasis from colonic carcinoma. A case report. J Bone Joint Surg Am. 1973; 55:398-400. 7. Daldrup-Link HE, Franzius C, Link TM et al. Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. AJR Am J Roentgenol. 2001; 177:229-36. 8. Delva R, Pein F

42 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 MECHANISMS OF BONE METASTASIS OF MALIGNANCIES OF THE GENITO-MAMMARY AREA doi: 10.2478/rojost-2018-0053 R. Bohîlțea1,2, N. Turcan2, T.A. Georgescu3, M.M. Cîrstoiu1,2 1”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania 3Department of Pathological Anatomy, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Bone metastasis is a

59 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 MAXILARY SUPPURATIVE INFLAMMATION ON CHRONIC TREATMENT WITH BISPHOSPHONATES FOR BONE METASTASIS – A CASE REPORT doi: 10.2478/rojost-2018-0070 D. Vrînceanu, M. Dumitru, B. Bănică, A. Nica University Emergency Hospital, Bucharest, Romania Introduction. Bisphosphonates represent a class of anti-resorbable bone care drugs that inhibit the function of active osteoclasts and reduce bone resorption. They are used in the Oncology and Hematology specialties as

examinations had a crucial role both in the diagnostic orientation and in the subsequent therapeutic decisions and proper monitoring under therapy. Keywords: renal cell carcinoma, expansile bone metastasis

osteosynthesis could not compensate the progressive bone loss and the permanent use of an external orthosis was mandatory. The survival rate was 82,81% at 6 months and 67,19% at 12 months. Conclusions. All patients could be mobilized. Two thirds of the patients will survive more than a year. The goals of osteosynthesis are the same, regardless the location of the fracture and implant used: pain amelioration, stability for immediate full weight bearing, durability for patient’s life expectancy. Keywords: bone metastasis, intramedullary nail, long bones

38 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 BONE METASTASIS SECONDARY TO VULVAR CANCER doi: 10.2478/rojost-2018-0049 C. Berceanu1, E. Brătilă2, M.M. Cîrstoiu3, S. Berceanu1, A.V. Tetileanu4, N. L. Voicu1, C. Mehedințu5 1Department of Obstetrics and Gynecology, Clinical University Emergency Hospital, Craiova, Romania; University of Medicine and Pharmacy, Craiova, Romania 2Department of Obstetrics, Gynecology and Neonatology, ”Panait Sârbu” Clinical Obstetrics and Gynecology Hospital, Bucharest, Romania

Abstract

The diagnosis of follicular thyroid cancer is based on postoperative histopathology assessment. In its minimally invasive form, the signs of vascular invasion and capsular infiltration may sometimes be seen only in a small tumor fragment; hence, the diagnosis should be based on multiple histopathology specimens. This case study is a report on a 70-year-old female who was diagnosed with spinal metastasis of follicular thyroid cancer. This diagnosis was established 5 years after partial strumectomy due to goiter and there were no signs of thyroid cancer in postoperative histopathology assessment. Based on this case and literature reports, the authors conclude that the diagnosis of follicular thyroid cancer, especially its minimally invasive forms, may pose a diagnostic problem even when based on postoperative histopathology.

20 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 FEMUR METASTASIS SECONDARY TO A CARCINOMA OF THE UTERINE CERVIX (CASE STUDY) doi: 10.2478/rojost-2018-0031 D. Popescu1, C. Panaitescu1, R. Nedelcu1, Șt. Trifu1, C. Cîrstoiu1,2 1Orthopedics and Traumatology Department, University Emergency Hospital, Bucharest, Romania 2“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Purpose. The purpose of this study is to correlate the existence of a unique bone metastasis of the femur, secondary to a