Background: Few data is available concerning the association between peripheral arterial disease (PAD) and red cell distribution width (RDW). In this study, we analyzed the relationship between RDW and atherosclerosis of the vessels other than coronary arteries in patients who had undergone digital substraction angiography (DSA). Methods: This study included 730 patients who had undergone DSA. Patients were divided into two groups according to their angiographic images. The association between RDW and atherosclerosis of peripheral arteries was analyzed. The relationship between atherosclerosis and smoking, hypertension (HT), diabetes mellitus (DM), hs-CRP, hemoglobin, white blood cell (WBC), triglyceride, total cholesterol, HDL and LDL cholesterol levels was assessed. Results: Atherosclerosis was observed more common in male and patients with older age, HT, DM and smoking (p<0.001). hs-CRP and WBC levels were both in significantly positive association with atherosclerosis (p<0.05). However, there were no significant differences in the RDW levels, hemoglobin, triglyceride, total cholesterol, LDL and HDL cholesterol levels in the groups (p>0.05). Conclusion: Our results seem to demonstrate that older age, male gender, HT, DM and smoking are powerful risk factors for PAD. In contrast to the previous reports, RDW levels are found not to be associated with atherosclerosis of peripheral arteries.
. Nephrol Dial Transplant 2008; 23: 2461-6. 17. Tsompanidi EM, Brinkmeier MS, Fotiadou EH, Giakoumi SM, Kypreo KE. HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis. Athero - sclerosis 2010; 208: 3-9. 18. Zeljkovic A, Vekic J, Spasojevic-Kalimanovska V, Jelic- Ivanovic Z, Peco-Antic A, Kostic M et al. Characteristics of low-density and high-density lipoprotein subclasses in pediatric renal transplant recipients. Transpl Int 2011; 24: 1094-102. 19. Sopić M, Joksić J, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Simić-Ogrizović S
Carotid Athero - sclerosis in a General Population Aged 35 to 55 years: The Asklepios study. Arterioscler Thromb Vasc Biol 2008; 28: 1563-8. 24. Vandermeersch A, Ameye S, Puype D, Petitjean D, De Buyzere M, Langlois M. Estimation of the low-density lipoprotein (LDL) subclass phenotype using a direct automated assay of small dense LDL-cholesterol without sample pretreatment. Clin Chim Acta 2010; 411: 1361-6. 25. Verhoye E, Langlois M. Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk? Clin Chem Lab Med 2009; 47(2): 128
activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia. Athero-sclerosis 2000; 151: 567–74. 52. Huang X, Zhao J, Zhao T. Effects of peroxisome prolifer-ator activated receptor-gamma 2 gene Pro12Ala polymorphism on fasting blood lipids: a meta-analysis. Atherosclerosis 2011; 215: 136–44. 53. Tavares V, Hirata RD, Rodrigues AC, Monte O, Salles JE, Scallissi N, et al. Effect of the peroxisome proliferator-activated receptor-gamma C161T polymorphism
ML, Deinum G, Myles JL, et al. Histopathology of human coronary atherosclerosis by quantifying its chemical composition with Raman spectroscopy. Circulation 1998; 97: 878-85. 12. Bushman HP, Motz JT, Deinum G, Römer TJ, Fitzmaurice M, Kramer JR, et al. Diagnosis of human coronary athero - sclerosis by morphology-based Raman spectroscopy. Cardiovasc Pathol 2001; 10: 59-68. 13. Hawi SR, Nithipatikom K, Wohlfeil ER, Adar F, Campbell WB. Raman microspectroscopy of intracellular cholesterol crystals in cultured bovine coronary artery endothelial cells. J Lipid Res 1997
acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 2006; 189(1): 19-30. 42. Rizzo M, Kotur-Stevuljevic J, Berneis K, Spinas G, Rini GB, Jelic-Ivanovic Z, et al. Atherogenic dyslipidemia and oxidative stress: a new look. Translational Research 2009; 153(5): 217-23. 43. Siddiqui RA, Harvey K, Stillwell W. Anticancer properties of oxidation products of docosahexaenoic acid. Chem Phys Lipids 2008; 153: 47-56. 44. Mori TA. Dietary n-3 PUFA and CVD: a review of the evidence. Proc Nutr Soc 2014; 73(1): 57-64. 45. Giordano E, Visioli
atherosclerosis J Atheroscler Thromb 2009 16 4 363 70 8 Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999; 142(1): 1–28. Brown AJ Jessup W Oxysterols and atherosclerosis Atherosclerosis 1999 142 1 1 28 9 Mougenot N, Lesnik P, Ramirez-Gil JF, Nataf P, Diczfalusy U, Chapman MJ, et al. Effect of the oxidation state of LDL on the modulation of arterial vasomotor response in vitro. Atherosclerosis 1997; 133(2): 183–92. 9298678 10.1016/S0021-9150(97)00124-X Mougenot N Lesnik P Ramirez-Gil JF Nataf P Diczfalusy U Chapman MJ Effect of the oxidation state of LDL