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aryloxyaminopropanol- structure biological activity relationship. (Review in Slovak). Farm Obzor. 2010;79:287-293. [6] Čižmarikova R, Dingova A, Kozlovsky J, Greksakova O.Derivatives of para-hydroxyacetophenones and parahydroxypropiophenones as novel potential beta-adrenolytic agent (in Slovak). Čes Slov Farm. 1990a;39:403-408. [7] Čižmarikova R, Mlynarčik D, Greksakova O, Račanska E: Unspezifische Wirkungen der Derivate des p-Hydroxypropiophenones - potentielle Beta-Adrenolytika.Pharmazie. 1990b;45:142-143. [8] Čižmarikova R, Kozlovsky J. Anticalcium effect of 4

Comeniaenae. 2010;57:24-32. Čižmarikova R, Bruchata K, Pastirova Z, Lehotay J, Hroboňova K. HPLC and TLC enantioseparation of the nitro-positioned aryloxysubstituted aminopropanols. Pharmazie. 2010;65:387-388. Čižmarikova R, Račanska E, Hroboňova K, Lehotay J, Aghova Z, Halešova D. Synthesis, pharmacological activity and chromatographic separation of some novel potential β-blockers of the aryloxyaminopropanol type. Pharmazie. 2003;58:237-241. Donnecke J, Paul C, Konig WA, Svensson LA, Gyllenhaal O, Vessman J. Immobilization of heptakis 6- O - terc -butyldimethylsilyl-2

enantioseparation of some potencial β-blockers of aryloxyaminopropanol type by HPLC using macrocyclic antibiotics as chiral selector. Acta Fac Pharm Univ Comen. 2006;53:68-75. Crowter AF, Smith LH. Beta-adrenergic blocking agents II. Propranolol and related 3-amino-1-naphthoxy-2-propanols. J Med Chem. 1968;11:1009-1013. Čižmáriková R, Hroboňová K, Lehotay J, Račanská E, Bruchatá K. Preparation, pharmacological activity and enantioseparation of [3-cyclopentyloxymethyl)-4-(2-hydroxy-3-isopropylaminopropoxy)phenyl]ethanone as potential β-blocker. Acta Fac Pharm Univ Comen. 2005

. Synthesis and pharmacological activity and chromatographic separation of novel potential β-blockers of the aryloxyaminopropanol type. Pharmazie. 2003;58:237-241. Heilker R, Wolff M, Tautermann ChS, Bieler M. G-protein-coupled receptor-focused drug discovery using a target class platform approach. Drug Discov Today. 2009;14:231-240. Hieble JP. Adrenoceptors subclassification: an approach to improved cardiovascular therapeutics. Pharmacochem Lib. 2000;31:163-171. Horn F, Weare J, Beukers MW, et al. GPCRDB: an information system for G proteincoupled receptors. Nucleic

. K. Bruchata and R. Cizmarikova, New derivatives of aryloxyaminopropanol-structure biological activity relationship, Farm. Obzor 79 (2010) 287-293. 4. D. P. Jindal, M. S. Coumara, G. Brunib and P. Massarelli, Synthesis and b1-, b2-adrenergic receptor binding studies of 4-acylamino-substituted phenoxypropanolamine and 5-acylamino-substitut- ed naphthyloxypropanolamine derivatives, Arzneim-Forsch/Drug Res. 52 (2002) 654-663; https://doi.org/10.1055/s-0031-1299947 5. V. Cecchetti, F. Schiaffella, O. Tabarrini and A. Fravolini, (1,4-Benzothiazinyloxy) alkoxylpiperazine